Hunan Medical School, Changsha, China
University of Virginia, Charlottesville, VA, USA
University of Kentucky, Lexington, KY, USA
With a long-term goal of identifying novel therapeutic targets for treatment of cardiovascular diseases, Dr. Guo’s research interest is to use genetically-modified mice and combine with molecular, cellular, and biochemical approaches to study transcriptional regulation and signal transduction in cultured vascular smooth muscle cells, organ culture, and animal models, and the implications in the physiopathology of hypertension, diabetes vascular complications, restenosis, and abdominal aortic aneurysm.
The current research projects in Dr. Guo’s laboratory follow:
The role of smooth muscle iPLA2β in transcriptional regulation of regulator of G protein signaling 2 (RGS2) by angiotensin II in cultured VSMC
The role of smooth muscle iPLA2β in diabetes-associated vascular smooth muscle hypercontractility and hypertension
The role of smooth muscle iPLA2β in initiation and early progression of vascular inflammation and neointima formation
The role of smooth muscle mineralocorticoid receptor in deoxycorticosterone acetate- or aldosterone-salt-induced abdominal aortic aneurysms
The role of smooth muscle BMAL1 in regulation of vascular smooth muscle contractile variability and blood pressure circadian rhythm
1. Guo Z, Turner C, Castle D (1998) Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell 94:537-548. PMCID: PMC Journal - In Process. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dop...
2. Guo Z, Su W, Ma Z, Smith GM, Gong MC (2003) Ca2+-independent Phospholipase A2 Is Required for Agonist-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle. J Biol Chem 278:1856-1863. PMCID: PMC Journal - In Process. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dop...
3. Xie Z, Gong MC, Su W, Turk J, Guo Z. (2007) Group VIA phospholipase A2 (iPLA2beta ) participates in angiotensin II-induced transcriptional upregulation of RGS2 in vascular smooth muscle cells. J Biol Chem. 282: 25278-89. PMCID: PMC2096773. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dop...
4. Xie Z, Gong M, Su W, Xie D, Turk J, Guo Z. (2010) Role of Calcium-independent Phospholipase A2β in High Glucose-induced Activation of RhoA, Rho-kinase, and CPI-17 in Cultured Vascular Smooth Muscle Cells and Vascular Smooth Muscle Hypercontractility in Diabetic Animals. J Biol Chem. 285(12):8628-38. PMCID: PMC2838285. http://www.ncbi.nlm.nih.gov/pubmed/20086008
5. Xie Z, Liu D, Liu S, Calderon L, Zhao G, Turk J, Guo Z. (2011) Identification of a cAMP response element in the RGS2 promoter as a Key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured VSMC. J Biol Chem. 286(52):44646-58. PMCID: PMC3247950. http://www.ncbi.nlm.nih.gov/pubmed/22057271
6. Liu S, Xie Z, Zhao Q, Pang H, Turk J, Calderon L, Su W, Zhao G, Xu H, Gong MC, and Guo Z. (2012) Smooth muscle-specific expression of calcium-independent phospholipase a2beta (ipla2beta) participates in the initiation and early progression of vascular inflammation and neointima formation. J Biol Chem. 287:24739-24753. PMCID: PMC3397901. http://www.ncbi.nlm.nih.gov/pubmed/22637477
- Zhao, G.; Zhong, Y.; Su, W.; Liu, S.; Song, X.; Hou, T.; Mu, X.; Gong, MC ; Guo, Z. "Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality." Molecular and cellular biology 39, 11 (2019): [PubMed Link] | [ Full text ]
- Hou, T.; Su, W.; Guo, Z.; Gong, MC "A Novel Diabetic Mouse Model for Real-Time Monitoring of Clock Gene Oscillation and Blood Pressure Circadian Rhythm." Journal of biological rhythms 34, 1 (2019): 51-68. [PubMed Link] | [ Full text ]
- Lutshumba, J.; Liu, S.; Zhong, Y.; Hou, T.; Daugherty, A.; Lu, H.; Guo, Z.; Gong, MC "Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms." Arteriosclerosis, thrombosis, and vascular biology 38, 5 (2018): 1063-1075. [PubMed Link] | [ Full text ]
- Liu, S.; Gong, MC ; Guo, Z. "A New Mouse Model for Introduction of Aortic Aneurysm by Implantation of Deoxycorticosterone Acetate Pellets or Aldosterone Infusion in the Presence of High Salt." Methods in molecular biology (Clifton, N.J.) 1614, (2017): 155-163. [PubMed Link] | [ Full text ]