Yadi Wu, Ph.D.

Bio / Education: 

Ph.D in immunology; Shanghai Institute of Biochemistry and Cell Biology, Chinese
Academy of Sciences, Shanghai, China

Selected Publications: 

1. Wu Y*, Wang Y, Yang X, Kang T, Zhao Y, Wang C, Evers BM, and Zhou BP*. Deubiquitinase USP28 Confers Breast Cancer with Stem Cell-like Traits by Stabilizing LSD1. Cell Reports, 2013, In press (* Correspondence Author)
2. Dong C, Yuan T*, Wu Y*, Wang Y*, Fan TW, Yao J, Lin Y, St Clair D, Evers BM, and Zhou BP. Loss of FBP1 by Snail-mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer. Cancer Cell, 23(3):316-31, 2013 (* Contribute equally).
3. Dong C, Wu Y, Wang Y, Wang C, Chi Y, Evers BM, and Zhou BP. Interaction with Suv39H1 is critical for Snail-mediated E-cadherin Repression in Breast Cancer. Oncogene, 32(11):1351-62, 2013.
4. Dong C, Wu Y, Wang Y, Yao J, Yu Y, Rychahou PG, Evers BM, and Zhou BP. G9a Interacts with Snail and is Critical for Snail-mediated E-cadherin Repression in Breast Cancer. J Clin Invest, 122(4):1469-86, 2012.
5. Lin Y*, Wu Y*, Li J, Dong C, Ye X, Chi Y.-I, Evers BM, and Zhou BP. The SNAG Domain of Snail1 Functions as a Molecular Hook for Recruiting Lysine-specific Demethylase 1, EMBO J, Jun 2;29(11):1803-16, 2010. (*Co-first author)
Paper was selected by Faculty 1000
Commentary Coverage: Christofori G, Snail1 links transcriptional control with epigenetic regulation, EMBO J, 29, 1787-1789, 2010
6. Wu Y and Zhou BP. Snail: More than Epithelial-Mesenchymal Transition. Cell Adhesion & Migration, 4(2), 199-203, 2010.
7. Wu Y and Zhou BP. TNFα/NF-κB/Snail pathway in cancer cell migration and invasion, British Journal of Cancer, 102(4):639-44, 2010.
8. Jin J, Yu Y, Zhang T, Zhou X, Zhou J, Jia L, Wu Y, Zhou BP, and Feng Y. Snail is Critical for the Metastasis of Ovarian Carcinoma, International Journal of Cancer, 126(9):2102-11, 2010.
9. Wu Y and Zhou BP. Inflammation: a driving force speeds cancer metastasis, Cell Cycle, 8(20), 2009.
10. Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, and Zhou BP. Stabilization of Snail Is Required for Inflammation-Induced Cell Migration and Invasion, Cancer Cell, 15(5):416-28, 2009.
Featured Article of May 2009 issue of Cancer Cell with commentary from:
Preview: Yang CC, Wolf DA. Inflamed snail speeds metastasis. Cancer Cell, 15(5):355-7, 2009.
Leading Edge: Smith OM, Metastasis proceeds at more than a Snail’s pace, Cell, 137, 591, 2009.
Nature Cell Migration Gateway: Baumann K, Inflammation-induced metastasis: Moving at a Snail's pace, June 2009.
11. Wu Y, Evers BM, and Zhou BP. Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation, J Biol Chem, 284(1):640-8, 2009.

yadi Wu

I focus on the breast cancer progression including metastasis, tumor dormancy and followed recurrence. Recurrence generally occurs relatively early, but remain indolent for protracted periods of time before becoming overt, life-threatening tumors. Despite the central role of recurrence in breast cancer mortality, little is known about the mechanisms responsible. Our recent studies suggested that Snail, a transcriptional repressor promoting mammary tumor recurrence is regulated by inflammation. Our further work will address the systemic, or "macroenvironmental", contribution to tumor dormancy and metastasis. We will use biochemical and animal model to elucidate the breast cancer metastasis and recurrence.

PubMed Publications: 

  • Wu, Y.;Wang, Y.;Lin, Y.;Liu, Y.;Wang, Y.;Jia, J.;Singh, P.;Chi, Y.I.;Wang, C.;Dong, C.;Li, W.;Tao, M.;Napier, D.;Shi, Q.;Deng, J.;B. Mark, E.;Zhou, B.P. "Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation." Nature communications 8, (2017): 14228. [PubMed Link] | [ Full text ]
  • Zhang, G.;Wu, Y.;Xu, D.;Yan, X. "Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a." DNA and cell biology 35, 11 (2016): 691-695. [PubMed Link] | [ Full text ]
  • Liu, S.;Ye, D.;Xu, D.;Liao, Y.;Zhang, L.;Liu, L.;Yu, W.;Wang, Y.;He, Y.;Hu, J.;Guo, W.;Wang, T.;Sun, B.;Song, H.;Yin, H.;Liu, J.;Wu, Y.;Zhu, H.;Zhou, B.P.;Deng, J.;Zhang, Z. "Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma." Oncotarget 7, 18 (2016): 25251-63. [PubMed Link] | [ Full text ]
  • Tao, M.;Liu, L.;Shen, M.;Zhi, Q.;Gong, F.R.;Zhou, B.P.;Wu, Y.;Liu, H.;Chen, K.;Shen, B.;Wu, M.Y.;Shou, L.M.;Li, W. "Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac." Cell cycle (Georgetown, Tex.) 15, 3 (2016): 381-93. [PubMed Link] | [ Full text ]
  • Cui, Z.;Song, L.;Hou, Z.;Han, Y.;Hu, Y.;Wu, Y.;Chen, W.;Mao, L. "PLU-1/JARID1B overexpression predicts proliferation properties in head and neck squamous cell carcinoma." Oncology reports 33, 5 (2015): 2454-60. [PubMed Link] | [ Full text ]
  • Liu, S.;Ye, D.;Guo, W.;Yu, W.;He, Y.;Hu, J.;Wang, Y.;Zhang, L.;Liao, Y.;Song, H.;Zhong, S.;Xu, D.;Yin, H.;Sun, B.;Wang, X.;Liu, J.;Wu, Y.;Zhou, B.P.;Zhang, Z.;Deng, J. "G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma." Oncotarget 6, 9 (2015): 6887-901. [PubMed Link] | [ Full text ]
  • Gong, F.R.;Wu, M.Y.;Shen, M.;Zhi, Q.;Xu, Z.K.;Wang, R.;Wang, W.J.;Zong, Y.;Li, Z.L.;Wu, Y.;Zhou, B.P.;Chen, K.;Tao, M.;Li, W. "PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21." Oncotarget 6, 21 (2015): 18469-83. [PubMed Link] | [ Full text ]
  • Shen, M.;Wu, M.Y.;Chen, L.P.;Zhi, Q.;Gong, F.R.;Chen, K.;Li, D.M.;Wu, Y.;Tao, M.;Li, W. "Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA." Scientific reports 5, (2015): 11836. [PubMed Link] | [ Full text ]
  • Liao, Y.;Song, H.;Xu, D.;Jiao, H.;Yao, F.;Liu, J.;Wu, Y.;Zhong, S.;Yin, H.;Liu, S.;Wang, X.;Guo, W.;Sun, B.;Han, B.;Chin, Y.E.;Deng, J. "Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway." Cell cycle (Georgetown, Tex.) 14, 9 (2015): 1403-12. [PubMed Link] | [ Full text ]
  • Shi, J.;Wang, Y.;Zeng, L.;Wu, Y.;Deng, J.;Zhang, Q.;Lin, Y.;Li, J.;Kang, T.;Tao, M.;Rusinova, E.;Zhang, G.;Wang, C.;Zhu, H.;Yao, J.;Zeng, Y.X.;Evers, B.M.;Zhou, M.M.;Zhou, B.P. "Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer." Cancer cell 25, 2 (2014): 210-25. [PubMed Link] | [ Full text ]
  • Wu, Y.;Zhou, B.P. "Epigenetic regulation of LSD1 during mammary carcinogenesis." Molecular & cellular oncology 1, 3 (2014): e963426. [PubMed Link] | [ Full text ]
  • Yin, Y.;Deng, X.;Liu, Z.;Baldwin, L.A.;Lefringhouse, J.;Zhang, J.;Hoff, J.T.;Erfani, S.F.;Rucker EB, 3rd;O'Connor, K.;Liu, C.;Wu, Y.;Zhou, B.P.;Yang, X.H. "CD151 represses mammary gland development by maintaining the niches of progenitor cells." Cell cycle (Georgetown, Tex.) 13, 17 (2014): 2707-22. [PubMed Link] | [ Full text ]
  • Wu, Y.;Wang, Y.;Yang, X.H.;Kang, T.;Zhao, Y.;Wang, C.;Evers, B.M.;Zhou, B.P. "The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells." Cell reports 5, 1 (2013): 224-36. [PubMed Link] | [ Full text ]
  • Dong, C.;Yuan, T.;Wu, Y.;Wang, Y.;Fan, T.W.;Miriyala, S.;Lin, Y.;Yao, J.;Shi, J.;Kang, T.;Lorkiewicz, P.;St Clair, D.;Hung, M.C.;Evers, B.M.;Zhou, B.P. "Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer." Cancer cell 23, 3 (2013): 316-31. [PubMed Link] | [ Full text ]
  • Wu, X.;Cao, W.;Wang, X.;Zhang, J.;Lv, Z.;Qin, X.;Wu, Y.;Chen, W. "TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer." Molecular cancer 12, 1 (2013): 151. [PubMed Link] | [ Full text ]
  • Dong, C.;Wu, Y.;Yao, J.;Wang, Y.;Yu, Y.;Rychahou, P.G.;Evers, B.M.;Zhou, B.P. "G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer." The Journal of clinical investigation 122, 4 (2012): 1469-86. [PubMed Link] | [ Full text ]
  • Jin, H.;Yu, Y.;Zhang, T.;Zhou, X.;Zhou, J.;Jia, L.;Wu, Y.;Zhou, B.P.;Feng, Y. "Snail is critical for tumor growth and metastasis of ovarian carcinoma." International journal of cancer 126, 9 (2010): 2102-11. [PubMed Link] | [ Full text ]
  • Lin, Y.;Wu, Y.;Li, J.;Dong, C.;Ye, X.;Chi, Y.I.;Evers, B.M.;Zhou, B.P. "The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1." The EMBO journal 29, 11 (2010): 1803-16. [PubMed Link] | [ Full text ]
  • Wu, Y.;Zhou, B.P. "Snail: More than EMT." Cell adhesion & migration 4, 2 (2010): 199-203. [PubMed Link] |
  • Wu, Y.;Zhou, B.P. "Inflammation: a driving force speeds cancer metastasis." Cell cycle (Georgetown, Tex.) 8, 20 (2009): 3267-73. [PubMed Link] | [ Full text ]
  • Wu, Y.;Deng, J.;Rychahou, P.G.;Qiu, S.;Evers, B.M.;Zhou, B.P. "Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion." Cancer cell 15, 5 (2009): 416-28. [PubMed Link] | [ Full text ]
  • Wu, Y.;Evers, B.M.;Zhou, B.P. "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation." The Journal of biological chemistry 284, 1 (2009): 640-8. [PubMed Link] | [ Full text ]
  • Wu, Y.;Zhou, B.P. "New insights of epithelial-mesenchymal transition in cancer metastasis." Acta biochimica et biophysica Sinica 40, 7 (2008): 643-50. [PubMed Link] |
  • Wu, Y.;Zhou, B.P. "Kinases meet at TSC." Cell research 17, 12 (2007): 971-3. [PubMed Link] | [ Full text ]
  • Bartholomeusz, G.;Wu, Y.;Ali Seyed, M.;Xia, W.;Kwong, K.Y.;Hortobagyi, G.;Hung, M.C. "Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis." Molecular carcinogenesis 45, 2 (2006): 73-83. [PubMed Link] | [ Full text ]
  • Lo, H.W.;Ali-Seyed, M.;Wu, Y.;Bartholomeusz, G.;Hsu, S.C.;Hung, M.C. "Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1." Journal of cellular biochemistry 98, 6 (2006): 1570-83. [PubMed Link] | [ Full text ]
  • Cha, T.L.;Zhou, B.P.;Xia, W.;Wu, Y.;Yang, C.C.;Chen, C.T.;Ping, B.;Otte, A.P.;Hung, M.C. "Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3." Science (New York, N.Y.) 310, 5746 (2005): 306-10. [PubMed Link] | [ Full text ]
  • Wu, Y.;Wang, Y.;Zhong, C.;Li, Y.;Li, X.;Sun, B. "The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response." International immunopharmacology 3, 10-11 (2003): 1457-65. [PubMed Link] | [ Full text ]
  • Wu, Y.;Lin, G.;Sun, B. "IRBP-specific Th1 cells from peripheral blood were predominant in the experimental autoimmune uveitis." Biochemical and biophysical research communications 302, 1 (2003): 150-5. [PubMed Link] | [ Full text ]
  • Hou, W.;Wu, Y.;Sun, S.;Shi, M.;Sun, Y.;Yang, C.;Pei, G.;Gu, Y.;Zhong, C.;Sun, B. "Pertussis toxin enhances Th1 responses by stimulation of dendritic cells." Journal of immunology (Baltimore, Md. : 1950) 170, 4 (2003): 1728-36. [PubMed Link] | [ Full text ]
  • Wu, Y.;Lin, Y.;Hou, W.;Wang, Y.;Sun, B. "IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice." Journal of neuroimmunology 137, 1-2 (2003): 154-63. [PubMed Link] | [ Full text ]