Xiang-An Li, Ph.D.

Bio / Education: 

Shandong University, Shandong,   China

B.S.

1978-1982

Chemistry

Shandong University,   Shandong, China

M.S.

1982-1985

Biochemistry

Osaka University School   of Medicine, Japan

Ph.D.

1991-1994

Biochemistry

National Cardiovascular Center, Osaka, Japan.

Postdoc

1998-2000

Molecular Biology

University of Kentucky Medical School, Kentucky

Postdoc

2000-2000

Molecular/Cell Biology

Research Description: 

The Li laboratory studies HDL and scavenger receptor BI (SR-BI). SR-BI is a receptor of HDL which plays a pivotal role in modulating HDL metabolism. While high HDL is well-recognized as a cardio-protective factor, mice deficient in SR-BI have a 2-fold increase in HDL levels but are susceptible to atherosclerosis, suggesting dysfunctional HDL in the absence of SR-BI. One of the focuses is to understand the mechanism of HDL dysfunction and its contribution to inflammatory diseases. Using SR-BI null mice, Li laboratory first reveals that SR-BI is a critical protective molecule against sepsis- a devastating disease costs 225,000 lives in US alone. Research focuses on understanding the molecular mechanisms underlying SR-BI protection with molecular, cellular and in vivo approaches, and translating the mechanistic study into effective therapy for sepsis.

PubMed Publications: 

  • Yuan, B.;Wu, C.;Wang, X.;Wang, D.;Liu, H.;Guo, L.;Li, X.A.;Han, J.;Feng, H. "High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer." Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 37, 3 (2016): 3581-8. [PubMed Link] | [ Full text ]
  • Li, J.;Wang, J.;Li, M.;Yin, L.;Li, X.A.;Zhang, T.G. "Up-regulated expression of scavenger receptor class B type 1 (SR-B1) is associated with malignant behaviors and poor prognosis of breast cancer." Pathology, research and practice 212, 6 (2016): 555-9. [PubMed Link] | [ Full text ]