Shanxi Medical University, MD
Peking Union Medical College, PhD
University of Alabama at Birmingham, Postdoc
One research focus of my lab is kidney diseases including obesity/diabetes associated renal complications, ischemia-reperfusion induced acute kidney disease and aging-related kidney dysfunction. Other research focus includes mechanisms of obesity-associated inflammation and insulin resistance.
Shuxia Wang, Sruti Shiva, Maria H. Poczatek, Victor Darley-Usmar, and Joanne E. Murphy-Ullrich (2002). Nitric oxide and cGMP-dependent protein kinase regulation of thrombospondin 1-dependent TGF-beta activation in response to high glucose exposure. J Biol Chem. 277(12), 9880-8.
Shuxia Wang, Xing Wu, Thomas M. Lincoln and Joanne E. Murphy-Ullrich (2003). Expression of constitutively active cGMP-dependent protein kinase prevents glucose-induced thrombospondin1 expression and TGF-beta activation. Diabetes. 52 (8), 2144-2150.
Shu Liu, Lihua Shi, and Shuxia Wang (2007). Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury. Am J Physiol Renal Physiol, 293 (5), F1727-35, PMID: 17881461
Dejan Nikolic, Shu Liu, Yanzhang Li, and Shuxia Wang (2011). Over-expression of constitutively active PKG-I protects female, but not male mice from diet-induced obesity. Obesity, 19 (4), 784-91, PMID: 20930715
Yanzhang Li, Xiaopeng Tong, Courtney Rumala, Kate Clemons, and Shuxia Wang (2011). Thrombospondin1 deficiency reduces obesity-associated inflammation and imporves insulin sensitivity in a diet-induced obese mouse model. PloS One, 6 (10): e26656. PMID:22160771.
Yanzhang Li, Xiaopeng Tong, Haisety Memeiti, Kate Clemons, and Shuxia Wang (2012). Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia reperfusion induced kidney injury. Am J of Physiol Renal Physiol, 302(5): F561-70. PMID: 22039525
Hasiyeti Maiamitiyiming, Yanzhnag Li, Wenpeng Cui, Xiaopeng Tong, Heather Norman, Xinyu Qi, and Shuxia Wang (2013). Increasing cGMP-dependent protein kinase I activity attenuates cisplatin induced acute kidney injury. Am J of Physiol-renal, 2013, July 3
Wenpeng Cui, Maimaitiyiming Hasiyeti, Xinyu Qi, Heather Norman, and Shuxia Wang (2013). Thrombospondin1 mediates renal dysfunction in a mouse model of high fat diet induced obesity. Am J of Physiol-renal, 2013, July 17.
Yanzhang Li, Xinyu qi, Xiaopeng Tong, and Shuxia Wang (2013). Thrombospondin1 stimulates TNF-alpha expression in macrophages though activation of TLR4 pathway. Cellular and Molecular Immunology, 2013, Aug. 19 (Epub ahead of print)