Susan S. Smyth, M.D., Ph.D.

Bio / Education: 
MD, University of North Carolina, Chapel Hill
PhD, Pharmacology, University of North Carolina, Chapel Hill

Dr. Susan Smyth is a physician scientist who combines clinical practice in cardiology with NIH- , VA-, and industry-funded research focused on the interplay between inflammation and thrombosis in vascular biology. Her training and expertise center around the contribution of extracellular mediators and blood and vascular cell-surface signaling receptors. Her team applies genetic and pharmacologic strategies in animal models of cardiovascular disease, in order to define cellular and molecular pathways, and then tests those pathways in clinical studies in humans. Her clinical interests are in arterial and venous thrombosis, and she leads an enterprise-wide effort in thrombosis prevention and management.  She has authored more than 150 publications and contributed to over a dozen textbooks. 

Smyth received her A.B. in Biology, summa cum laude, from Mount Holyoke College (South Hadley, Massachusetts), and graduated from the MD/PhD Program at the University of North Carolina (Chapel Hill, NC). As a graduate student, she studied activation of the platelet integrin αIIbβ3.  After completing training in Internal Medicine, she performed cardiology subspecialty fellowship training at the Mount Sinai School of Medicine (New York, New York) and at the University of North Carolina.  While a fellow at Mount Sinai, Smyth established animal models to study platelet and other cell-surface receptors in thrombosis and vascular biology.  During this time, she developed an interest in understanding the interesection of thrombosis and inflammation based on observations of platelet – leukocyte interactions in models of vascular disease. Smyth joined the faculty of the University of North Carolina as an Assistant Professor of Medicine and Physiology in 2001. During her tenure at UNC, her group expanded their research to understanding of the role of bioactive, extracellular lysolipids in vascular biology.  She joined the faculty of at the University of Kentucky (Lexington, Kentucky) in 2006 and currently holds appointments in the Departments of Internal Medicine, Pharmacology, Physiology, and Behavioral Sciences.  Smyth is part of a research team whose work spans molecular, preclinical and clinical models, with an aim to connect discovery science to prevent cardiovascular disease and promote health.

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ATX-LPA-LPP3 nexus


Select Honors and Positions

2000      Faculty Scholar Award, American Society of Hematology
2003      American Heart Association Young Investigator Prize in Thrombosis, finalist
2005-     Editorial Panel: Clinical Science
2007-     Editorial Board, Arteriosclerosis, Thrombosis and Vascular Biology
2008      Special Recognition Award in Thrombosis, ATVB Council, American Heart Association
2009      Stewart-Nierwiarowski Award for Women in Vascular Biology
2009      Member, American Society of Clinical Investigation
2010     Associate Editor, Journal Thrombosis and Thrombolysis (section editor Fellow’s Forum)
2012      Consulting Editor, Journal of Clinical Investigation
2013      Jeffrey M. Hoeg Arteriosclerosis Award for Basic Science and Clinical Research
2013      Member, Association of University Cardiologists
2016      Board of Governors, American College of Cardiology
2016      PERT Consortium™, Founding Board Member
2017      Chair, FASEB conference on Lysophospholipids in Health and Disease
PubMed Publications: 

  • Brewster, J.;Sexton, T.;Dhaliwal, G.;Charnigo, R.;Morales, G.;Parrott, K.;Darrat, Y.;Gurley, J.;Smyth, S.;Elayi, C.S. "Acute Effects of Implantable Cardioverter-Defibrillator Shocks on Biomarkers of Myocardial Injury, Apoptosis, Heart Failure, and Systemic Inflammation." Pacing and clinical electrophysiology : PACE (2017): [PubMed Link] | [ Full text ]
  • Kotter, J.;Lolay, G.;Charnigo, R.;Leung, S.;McKibbin, C.;Sousa, M.;Jimenez, L.;Gurley, J.;Biase, L.D.;Natale, A.;Smyth, S.;Darrat, Y.;Morales, G.;Elayi, C.S. "Predictors, Morbidity, and Costs Associated with Pneumothorax during Electronic Cardiac Device Implantation." Pacing and clinical electrophysiology : PACE 39, 9 (2016): 985-91. [PubMed Link] | [ Full text ]
  • Morris, A.J.;Smyth, S.S. "Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins." Arteriosclerosis, thrombosis, and vascular biology 36, 10 (2016): 2029-30. [PubMed Link] | [ Full text ]
  • Sexton, T.R.;Wallace, E.L.;Chen, A.;Charnigo, R.J.;Reda, H.K.;Ziada, K.M.;Gurley, J.C.;Smyth, S.S. "Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement." Journal of thrombosis and thrombolysis 41, 3 (2016): 384-93. [PubMed Link] | [ Full text ]
  • Sexton, T.;Wallace, E.L.;Smyth, S.S. "Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte Interactions." Current cardiology reviews 12, 4 (2016): 324-329. [PubMed Link] | [ Full text ]