Sean Eric Thatcher, Ph.D.

Bio / Education: 

BS and MS, Morehead State University, 1994-2001
PhD, Marshall University, 2001-2007

Mentor: 
Dr. Lisa A. Cassis, PhD
Research Description: 

My research involves the study of angiotensin converting enzyme 2 (ACE2) and the effects of ACE2 deficiency in cardiovascular disease, obesity, and inflammation. ACE2 catabolizes angiotensin II to form the vasoprotective peptide, angiotensin-(1-7). Recent work has shown that chronic angiotensin-(1-7) infusion by osmotic pump, lowers angiotensin II-induced atherosclerosis. Current projects look to evaluate the role of ACE2 in the immune system and to understand the role of ACE2 in macrophages.

Grants: 

F32HL095281, ACE2 in Hypercholesterolemia and Angiotensin II-Induced Vascular Disease (Ruth L. Kirschstein National Research Service Award, 2009-2012)

PubMed Publications: 

  • Alsiraj, Y.;Thatcher, S.E.;Charnigo, R.;Chen, K.;Blalock, E.;Daugherty, A.;Cassis, L.A. "Female Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II-Induced Abdominal Aortic Aneurysms." Circulation 135, 4 (2017): 379-391. [PubMed Link] | [ Full text ]
  • Vasam, G.;Joshi, S.;Thatcher, S.E.;Bartelmez, S.H.;Cassis, L.A.;Jarajapu, Y.P. "Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes." Diabetes 66, 2 (2017): 505-518. [PubMed Link] | [ Full text ]
  • Thatcher, S.E. "TGF-β Signaling: New Insights Into Aortic Aneurysms." EBioMedicine 12, (2016): 24-25. [PubMed Link] | [ Full text ]
  • Wang, Y.;Shoemaker, R.;Powell, D.;Su, W.;Thatcher, S.E.;Cassis, L.A. "Differential Effects of Mas Receptor Deficiency on Cardiac Function and Blood Pressure in Obese Male and Female Mice." American journal of physiology. Heart and circulatory physiology (2016): ajpheart.00498.2016. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Zhang, X.;Woody, S.;Wang, Y.;Alsiraj, Y.;Charnigo, R.;Daugherty, A.;Cassis, L.A. "Exogenous 17-β estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice." Biology of sex differences 6, (2015): 12. [PubMed Link] | [ Full text ]
  • Wang, Y.;Shoemaker, R.;Thatcher, S.E.;Batifoulier-Yiannikouris, F.;English, V.L.;Cassis, L.A. "Administration of 17β-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism." American journal of physiology. Endocrinology and metabolism 308, 12 (2015): E1066-75. [PubMed Link] | [ Full text ]
  • Tanaka, H.;Wang, H.H.;Thatcher, S.E.;Hagiwara, H.;Takano-Ohmuro, H.;Kohama, K. "Electron microscopic examination of podosomes induced by phorbol 12, 13 dibutyrate on the surface of A7r5 cells." Journal of pharmacological sciences 128, 2 (2015): 78-82. [PubMed Link] | [ Full text ]
  • Shoemaker, R.;Yiannikouris, F.;Thatcher, S.E.;Cassis, L.A. "ACE2 Deficiency Reduces Beta-Cell Mass and Impairs Beta-Cell Proliferation in Obese C57BL/6 Mice." American journal of physiology. Endocrinology and metabolism (2015): ajpendo.00054.2015. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Zhang, X.;Howatt, D.A.;Yiannikouris, F.;Gurley, S.B.;Ennis, T.;Curci, J.A.;Daugherty, A.;Cassis, L.A. "Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 34, 12 (2014): 2617-23. [PubMed Link] | [ Full text ]
  • Zhang, X.;Thatcher, S.E.;Rateri, D.L.;Bruemmer, D.;Charnigo, R.;Daugherty, A.;Cassis, L.A. "Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms." Circulation research 110, 11 (2012): e73-85. [PubMed Link] | [ Full text ]
  • Gupte, M.;Thatcher, S.E.;Boustany-Kari, C.M.;Shoemaker, R.;Yiannikouris, F.;Zhang, X.;Karounos, M.;Cassis, L.A. "Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice." Arteriosclerosis, thrombosis, and vascular biology 32, 6 (2012): 1392-9. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Gupte, M.;Hatch, N.;Cassis, L.A. "Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice." International journal of hypertension 2012, (2012): 762094. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Zhang, X.;Howatt, D.A.;Lu, H.;Gurley, S.B.;Daugherty, A.;Cassis, L.A. "Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice." Arteriosclerosis, thrombosis, and vascular biology 31, 4 (2011): 758-65. [PubMed Link] | [ Full text ]
  • Police, S.B.;Thatcher, S.E.;Charnigo, R.;Daugherty, A.;Cassis, L.A. "Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation." Arteriosclerosis, thrombosis, and vascular biology 29, 10 (2009): 1458-64. [PubMed Link] | [ Full text ]
  • Cassis, L.A.;Police, S.B.;Yiannikouris, F.;Thatcher, S.E. "Local adipose tissue renin-angiotensin system." Current hypertension reports 10, 2 (2008): 93-8. [PubMed Link] |