Sean Eric Thatcher, Ph.D.

Bio / Education: 

BS and MS, Morehead State University, 1994-2001
PhD, Marshall University, 2001-2007

Dr. Lisa A. Cassis, PhD
Research Description: 

My research involves the study of angiotensin converting enzyme 2 (ACE2) and the effects of ACE2 deficiency in cardiovascular disease, obesity, and inflammation. ACE2 catabolizes angiotensin II to form the vasoprotective peptide, angiotensin-(1-7). Recent work has shown that chronic angiotensin-(1-7) infusion by osmotic pump, lowers angiotensin II-induced atherosclerosis. Current projects look to evaluate the role of ACE2 in the immune system and to understand the role of ACE2 in macrophages.


F32HL095281, ACE2 in Hypercholesterolemia and Angiotensin II-Induced Vascular Disease (Ruth L. Kirschstein National Research Service Award, 2009-2012)

PubMed Publications: 

  • Alsiraj, Y.;Thatcher, S.E.;Charnigo, R.;Chen, K.;Blalock, E.;Daugherty, A.;Cassis, L.A. "Female Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II-Induced Abdominal Aortic Aneurysms." Circulation 135, 4 (2017): 379-391. [PubMed Link] | [ Full text ]
  • Vasam, G.;Joshi, S.;Thatcher, S.E.;Bartelmez, S.H.;Cassis, L.A.;Jarajapu, Y.P. "Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes." Diabetes 66, 2 (2017): 505-518. [PubMed Link] | [ Full text ]
  • Thatcher, S.E. "TGF-β Signaling: New Insights Into Aortic Aneurysms." EBioMedicine 12, (2016): 24-25. [PubMed Link] | [ Full text ]
  • Wang, Y.;Shoemaker, R.;Powell, D.;Su, W.;Thatcher, S.E.;Cassis, L.A. "Differential Effects of Mas Receptor Deficiency on Cardiac Function and Blood Pressure in Obese Male and Female Mice." American journal of physiology. Heart and circulatory physiology (2016): ajpheart.00498.2016. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Zhang, X.;Woody, S.;Wang, Y.;Alsiraj, Y.;Charnigo, R.;Daugherty, A.;Cassis, L.A. "Exogenous 17-β estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice." Biology of sex differences 6, (2015): 12. [PubMed Link] | [ Full text ]
  • Wang, Y.;Shoemaker, R.;Thatcher, S.E.;Batifoulier-Yiannikouris, F.;English, V.L.;Cassis, L.A. "Administration of 17β-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism." American journal of physiology. Endocrinology and metabolism 308, 12 (2015): E1066-75. [PubMed Link] | [ Full text ]
  • Tanaka, H.;Wang, H.H.;Thatcher, S.E.;Hagiwara, H.;Takano-Ohmuro, H.;Kohama, K. "Electron microscopic examination of podosomes induced by phorbol 12, 13 dibutyrate on the surface of A7r5 cells." Journal of pharmacological sciences 128, 2 (2015): 78-82. [PubMed Link] | [ Full text ]
  • Shoemaker, R.;Yiannikouris, F.;Thatcher, S.E.;Cassis, L.A. "ACE2 Deficiency Reduces Beta-Cell Mass and Impairs Beta-Cell Proliferation in Obese C57BL/6 Mice." American journal of physiology. Endocrinology and metabolism (2015): ajpendo.00054.2015. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Zhang, X.;Howatt, D.A.;Yiannikouris, F.;Gurley, S.B.;Ennis, T.;Curci, J.A.;Daugherty, A.;Cassis, L.A. "Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 34, 12 (2014): 2617-23. [PubMed Link] | [ Full text ]
  • Zhang, X.;Thatcher, S.E.;Rateri, D.L.;Bruemmer, D.;Charnigo, R.;Daugherty, A.;Cassis, L.A. "Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms." Circulation research 110, 11 (2012): e73-85. [PubMed Link] | [ Full text ]
  • Gupte, M.;Thatcher, S.E.;Boustany-Kari, C.M.;Shoemaker, R.;Yiannikouris, F.;Zhang, X.;Karounos, M.;Cassis, L.A. "Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice." Arteriosclerosis, thrombosis, and vascular biology 32, 6 (2012): 1392-9. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Gupte, M.;Hatch, N.;Cassis, L.A. "Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice." International journal of hypertension 2012, (2012): 762094. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Zhang, X.;Howatt, D.A.;Lu, H.;Gurley, S.B.;Daugherty, A.;Cassis, L.A. "Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice." Arteriosclerosis, thrombosis, and vascular biology 31, 4 (2011): 758-65. [PubMed Link] | [ Full text ]
  • Police, S.B.;Thatcher, S.E.;Charnigo, R.;Daugherty, A.;Cassis, L.A. "Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation." Arteriosclerosis, thrombosis, and vascular biology 29, 10 (2009): 1458-64. [PubMed Link] | [ Full text ]
  • Cassis, L.A.;Police, S.B.;Yiannikouris, F.;Thatcher, S.E. "Local adipose tissue renin-angiotensin system." Current hypertension reports 10, 2 (2008): 93-8. [PubMed Link] |