Robert W. Hadley, Ph.D.

Bio / Education: 

1983 B.S. (Pharmacy), Purdue University
1987 Ph.D. (Pharmacology), Michigan State University
1990 Post-doc (Physiology), University of Maryland

PubMed Publications: 

  • García-Cazarín, M.L.;Smith, J.L.;Olszewski, K.A.;McCune, D.F.;Simmerman, L.A.;Hadley, R.W.;Kraner, S.D.;Piascik, M.T. "The alpha1D-adrenergic receptor is expressed intracellularly and coupled to increases in intracellular calcium and reactive oxygen species in human aortic smooth muscle cells." Journal of molecular signaling 3, (2008): 6. [PubMed Link] | [ Full text ]
  • Eigel, B.N.;Gursahani, H.;Hadley, R.W. "Na+/Ca2+ exchanger plays a key role in inducing apoptosis after hypoxia in cultured guinea pig ventricular myocytes." American journal of physiology. Heart and circulatory physiology 287, 4 (2004): H1466-75. [PubMed Link] | [ Full text ]
  • Eigel, B.N.;Gursahani, H.;Hadley, R.W. "ROS are required for rapid reactivation of Na+/Ca2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes." American journal of physiology. Heart and circulatory physiology 286, 3 (2004): H955-63. [PubMed Link] | [ Full text ]
  • Nasr, P.;Gursahani, H.I.;Pang, Z.;Bondada, V.;Lee, J.;Hadley, R.W.;Geddes, J.W. "Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid." Neurochemistry international 43, 2 (2003): 89-99. [PubMed Link] | [ Full text ]
  • Eigel, B.N.;Hadley, R.W. "Antisense inhibition of Na+/Ca2+ exchange during anoxia/reoxygenation in ventricular myocytes." American journal of physiology. Heart and circulatory physiology 281, 5 (2001): H2184-90. [PubMed Link] | [ Full text ]
  • Eigel, B.N.;Hadley, R.W. "Contribution of the Na(+) channel and Na(+)/H(+) exchanger to the anoxic rise of Na(+) in ventricular myocytes." The American journal of physiology 277, 5 Pt 2 (1999): H1817-22. [PubMed Link] | [ Full text ]
  • Hrometz, S.L.;Edelmann, S.E.;McCune, D.F.;Olges, J.R.;Hadley, R.W.;Perez, D.M.;Piascik, M.T. "Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction." The Journal of pharmacology and experimental therapeutics 290, 1 (1999): 452-63. [PubMed Link] | [ Full text ]
  • Delcamp, T.J.;Dales, C.;Ralenkotter, L.;Cole, P.S.;Hadley, R.W. "Intramitochondrial Ca2+ and membrane potential in ventricular myocytes exposed to anoxia-reoxygenation." The American journal of physiology 275, 2 Pt 2 (1998): H484-94. [PubMed Link] | [ Full text ]
  • Piascik, M.T.;Hrometz, S.L.;Edelmann, S.E.;Guarino, R.D.;Hadley, R.W.;Brown, R.D. "Immunocytochemical localization of the alpha-1B adrenergic receptor and the contribution of this and the other subtypes to vascular smooth muscle contraction: analysis with selective ligands and antisense oligonucleotides." The Journal of pharmacology and experimental therapeutics 283, 2 (1997): 854-68. [PubMed Link] | [ Full text ]
  • Ralenkotter, L.;Dales, C.;Delcamp, T.J.;Hadley, R.W. "Cytosolic Ca2+ , Na+ , and pH in guinea pig ventricular myocytes exposed to anoxia and reoxygenation." The American journal of physiology 272, 6 Pt 2 (1997): H2679-85. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Lederer, W.J. "Nifedipine inhibits movement of cardiac calcium channels through late, but not early, gating transitions." The American journal of physiology 269, 5 Pt 2 (1995): H1784-90. [PubMed Link] | [ Full text ]
  • Kirby, M.S.;Hadley, R.W.;Lederer, W.J. "Measurement of intracellular Ca2+ concentration using Indo-1 during simultaneous flash photolysis to release Ca2+ from DM-nitrophen." Pflugers Archiv : European journal of physiology 427, 1-2 (1994): 169-77. [PubMed Link] |
  • Hadley, R.W.;Kirby, M.S.;Lederer, W.J.;Kao, J.P. "Does the use of DM-nitrophen, nitr-5, or diazo-2 interfere with the measurement of indo-1 fluorescence?" Biophysical journal 65, 6 (1993): 2537-46. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Lederer, W.J. "Comparison of the effects of BAY K 8644 on cardiac Ca2+ current and Ca2+ channel gating current." The American journal of physiology 262, 2 Pt 2 (1992): H472-7. [PubMed Link] | [ Full text ]
  • Kofuji, P.;Hadley, R.W.;Kieval, R.S.;Lederer, W.J.;Schulze, D.H. "Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger." The American journal of physiology 263, 6 Pt 1 (1992): C1241-9. [PubMed Link] | [ Full text ]
  • Lederer, W.J.;Niggli, E.;Hadley, R.W. "Response." Science (New York, N.Y.) 251, 4999 (1991): 1371. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Lederer, W.J. "Ca2+ and voltage inactivate Ca2+ channels in guinea-pig ventricular myocytes through independent mechanisms." The Journal of physiology 444, (1991): 257-68. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Lederer, W.J. "Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes." The Journal of general physiology 98, 2 (1991): 265-85. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Hume, J.R. "Permeability of time-dependent K+ channel in guinea pig ventricular myocytes to Cs+, Na+, NH4+, and Rb+." The American journal of physiology 259, 5 Pt 2 (1990): H1448-54. [PubMed Link] | [ Full text ]
  • Lederer, W.J.;Niggli, E.;Hadley, R.W. "Sodium-calcium exchange in excitable cells: fuzzy space." Science (New York, N.Y.) 248, 4953 (1990): 283. [PubMed Link] | [ Full text ]
  • Lederer, W.J.;Berlin, J.R.;Cohen, N.M.;Hadley, R.W.;Bers, D.M.;Cannell, M.B. "Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum." Annals of the New York Academy of Sciences 588, (1990): 190-206. [PubMed Link] | [ Full text ]
  • Hume, J.R.;Uehara, A.;Hadley, R.W.;Harvey, R.D. "Comparison of K+ channels in mammalian atrial and ventricular myocytes." Progress in clinical and biological research 334, (1990): 17-41. [PubMed Link] |
  • Hadley, R.W.;Lederer, W.J. "Intramembrane charge movement in guinea-pig and rat ventricular myocytes." The Journal of physiology 415, (1989): 601-24. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Hume, J.R. "Calcium channel antagonist properties of Bay K 8644 in single guinea pig ventricular cells." Circulation research 62, 1 (1988): 97-104. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Hume, J.R. "An intrinsic potential-dependent inactivation mechanism associated with calcium channels in guinea-pig myocytes." The Journal of physiology 389, (1987): 205-22. [PubMed Link] | [ Full text ]
  • Bielefeld, D.R.;Hadley, R.W.;Vassilev, P.M.;Hume, J.R. "Membrane electrical properties of vesicular Na-Ca exchange inhibitors in single atrial myocytes." Circulation research 59, 4 (1986): 381-9. [PubMed Link] | [ Full text ]
  • Vassilev, P.M.;Hadley, R.W.;Lee, K.S.;Hume, J.R. "Voltage-dependent action of tetrodotoxin in mammalian cardiac myocytes." The American journal of physiology 251, 2 Pt 2 (1986): H475-80. [PubMed Link] | [ Full text ]
  • Hadley, R.W.;Hume, J.R. "Actions of phencyclidine on the action potential and membrane currents of single guinea-pig myocytes." The Journal of pharmacology and experimental therapeutics 237, 1 (1986): 131-6. [PubMed Link] | [ Full text ]