Philip W Landfield, Ph.D.

Bio / Education: 

University of California, Irvine Ph.D. (1972) Psychobiology
University of North Carolina, Chapel Hill, Postdoc, (1972-1974) Neurobiology

Mentor: 
McGaugh, James , PhD.
Research Description: 

Our group has a long-standing interest in the neurobiology of brain aging, Alzheimer’s disease and associated cognitive decline. To study these phenomena at fundamental levels, my lab has used a multidisciplinary approach that has included behavioral testing, single-cell electrophysiology, endocrinology, molecular biology, viral vector gene manipulation, immunohistochemistry, E.M., and extensive gene microarray analyses of animal and human brain tissues. Our recent work has focused on determining when the markers of unhealthy brain aging begin to emerge and identifying the underlying pathways that may play a mechanistic role. In addition, we are investigating the interactions among the multiple processes altered with brain aging/AD. We have also conducted numerous long-term studies using steroid hormonal/pharmacological intervention treatments, attempting to retard the course of brain decline and test basic mechanistic hypotheses. These approaches have revealed that the onset of unhealthy brain aging is associated with the emergence of hippocampal neuronal Ca2+ dysregulation and reactive glial processes related to glucocorticoid signaling, lipid/glucose metabolism, inflammation and myelin programs, among other processes. Our experience with brain aging, multidisciplinary approaches and statistical analyses of massive gene array datasets appears to place us in a favorable position for elucidating mechanisms and potential targets of cognitive decline in Alzheimer’s disease and brain aging.

PubMed Publications: 

  • Gant, J.C.;Chen, K.C.;Kadish, I.;Blalock, E.M.;Thibault, O.;Porter, N.M.;Landfield, P.W. "Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 30 (2015): 10878-87. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Porter, N.M.;Norris, C.M.;Thibault, O.;Landfield, P.W. "FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?" European journal of pharmacology 739, (2014): 74-82. [PubMed Link] | [ Full text ]
  • Latimer, C.S.;Brewer, L.D.;Searcy, J.L.;Chen, K.C.;Popović, J.;Kraner, S.D.;Thibault, O.;Blalock, E.M.;Landfield, P.W.;Porter, N.M. "Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats." Proceedings of the National Academy of Sciences of the United States of America 111, 41 (2014): E4359-66. [PubMed Link] | [ Full text ]
  • Thibault, O.;Anderson, K.L.;Demoll, C.;Brewer, L.D.;Landfield, P.W.;Porter, N.M. "Hippocampal calcium dysregulation at the nexus of diabetes and brain aging." European journal of pharmacology 719, 1-3 (2013): 34-43. [PubMed Link] | [ Full text ]
  • Chen, K.C.;Blalock, E.M.;Curran-Rauhut, M.A.;Kadish, I.;Blalock, S.J.;Brewer, L.;Porter, N.M.;Landfield, P.W. "Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging." Endocrinology 154, 8 (2013): 2807-20. [PubMed Link] | [ Full text ]
  • Pancani, T.;Anderson, K.L.;Brewer, L.D.;Kadish, I.;Demoll, C.;Landfield, P.W.;Blalock, E.M.;Porter, N.M.;Thibault, O. "Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats." Neurobiology of aging 34, 8 (2013): 1977-87. [PubMed Link] | [ Full text ]
  • Craft, S.;Foster, T.C.;Landfield, P.W.;Maier, S.F.;Resnick, S.M.;Yaffe, K. "Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes." The journals of gerontology. Series A, Biological sciences and medical sciences 67, 7 (2012): 754-9. [PubMed Link] | [ Full text ]
  • Thibault, O.;Pancani, T.;Landfield, P.W.;Norris, C.M. "Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease." Biochimica et biophysica acta 1822, 4 (2012): 546-9. [PubMed Link] | [ Full text ]
  • Searcy, J.L.;Phelps, J.T.;Pancani, T.;Kadish, I.;Popovic, J.;Anderson, K.L.;Beckett, T.L.;Murphy, M.P.;Chen, K.C.;Blalock, E.M.;Landfield, P.W.;Porter, N.M.;Thibault, O. "Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease." Journal of Alzheimer's disease : JAD 30, 4 (2012): 943-61. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Buechel, H.M.;Popovic, J.;Geddes, J.W.;Landfield, P.W. "Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease." Journal of chemical neuroanatomy 42, 2 (2011): 118-26. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Norris, C.M.;Kadish, I.;Thibault, O.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 5 (2011): 1693-703. [PubMed Link] | [ Full text ]
  • Latimer, C.S.;Searcy, J.L.;Bridges, M.T.;Brewer, L.D.;Popović, J.;Blalock, E.M.;Landfield, P.W.;Thibault, O.;Porter, N.M. "Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice." PloS one 6, 10 (2011): e26812. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Chen, K.C.;Porter, N.M.;Thibault, O.;Kraner, S.D.;Landfield, P.W. "Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging." Neurobiology of aging 31, 2 (2010): 328-38. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Grondin, R.;Chen, K.C.;Thibault, O.;Thibault, V.;Pandya, J.D.;Dowling, A.;Zhang, Z.;Sullivan, P.;Porter, N.M.;Landfield, P.W. "Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys." The Journal of neuroscience : the official journal of the Society for Neuroscience 30, 17 (2010): 6058-71. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Dowling, A.L.;Curran-Rauhut, M.A.;Landfield, P.W.;Porter, N.M.;Blalock, E.M. "Estradiol reverses a calcium-related biomarker of brain aging in female rats." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 19 (2009): 6058-67. [PubMed Link] | [ Full text ]
  • Kadish, I.;Thibault, O.;Blalock, E.M.;Chen, K.C.;Gant, J.C.;Porter, N.M.;Landfield, P.W. "Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 6 (2009): 1805-16. [PubMed Link] | [ Full text ]
  • Rowe, W.B.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Wang, D.;Barrett, J.E.;Thibault, O.;Porter, N.M.;Rose, G.M.;Landfield, P.W. "Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 12 (2007): 3098-110. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Thibault, O.;Staton, J.;Thibault, V.;Rogers, J.T.;Garcia-Ramos, G.;Kraner, S.;Landfield, P.W.;Porter, N.M. "Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels." Brain research 1151, (2007): 20-31. [PubMed Link] | [ Full text ]
  • Thibault, O.;Gant, J.C.;Landfield, P.W. "Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store." Aging cell 6, 3 (2007): 307-17. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Blalock, E.M.;Chen, K.C.;Porter, N.M. "A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease." Current Alzheimer research 4, 2 (2007): 205-12. [PubMed Link] |
  • Brewer, L.D.;Porter, N.M.;Kerr, D.S.;Landfield, P.W.;Thibault, O. "Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging." Cell calcium 40, 3 (2006): 277-86. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Thibault, O.;Brewer, L.D.;Clodfelter, G.V.;Porter, N.M.;Landfield, P.W. "Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release." Journal of neurophysiology 96, 5 (2006): 2488-500. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Sama, M.M.;Landfield, P.W.;Thibault, O. "Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release." The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 13 (2006): 3482-90. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Stromberg, A.J.;Norris, C.M.;Kadish, I.;Kraner, S.D.;Porter, N.M.;Landfield, P.W. "Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation." Ageing research reviews 4, 4 (2005): 481-512. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Kadish, I.;Blalock, E.M.;Chen, K.C.;Thibault, V.;Porter, N.M.;Landfield, P.W.;Kraner, S.D. "Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models." The Journal of neuroscience : the official journal of the Society for Neuroscience 25, 18 (2005): 4649-58. [PubMed Link] | [ Full text ]
  • Toescu, E.C.;Verkhratsky, A.;Landfield, P.W. "Ca2+ regulation and gene expression in normal brain aging." Trends in neurosciences 27, 10 (2004): 614-20. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Geddes, J.W.;Chen, K.C.;Porter, N.M.;Markesbery, W.R.;Landfield, P.W. "Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses." Proceedings of the National Academy of Sciences of the United States of America 101, 7 (2004): 2173-8. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Sharrow, K.;Herman, J.P.;Porter, N.M.;Foster, T.C.;Landfield, P.W. "Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 23, 9 (2003): 3807-19. [PubMed Link] | [ Full text ]
  • Peng, X.;Wood, C.L.;Blalock, E.M.;Chen, K.C.;Landfield, P.W.;Stromberg, A.J. "Statistical implications of pooling RNA samples for microarray experiments." BMC bioinformatics 4, (2003): 26. [PubMed Link] | [ Full text ]
  • Clodfelter, G.V.;Porter, N.M.;Landfield, P.W.;Thibault, O. "Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons." European journal of pharmacology 447, 2-3 (2002): 189-200. [PubMed Link] | [ Full text ]
  • Verkhratsky, A.;Landfield, P.W.;Thibault, O. "Preface. Ca2+ and neuronal pathology." European journal of pharmacology 447, 2-3 (2002): 115-7. [PubMed Link] | [ Full text ]
  • Attucci, S.;Clodfelter, G.V.;Thibault, O.;Staton, J.;Moroni, F.;Landfield, P.W.;Porter, N.M. "Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity." Neuroscience 112, 1 (2002): 183-94. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Chen, K.C.;Porter, N.M.;Landfield, P.W. "Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture." Neuroscience 110, 2 (2002): 213-25. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Vanaman, T.C.;Landfield, P.W.;Slevin, J.T. "Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices." Epilepsy research 43, 3 (2001): 211-26. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Thibault, V.;Chen, K.C.;Langub, M.C.;Landfield, P.W.;Porter, N.M. "Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 21, 1 (2001): 98-108. [PubMed Link] | [ Full text ]
  • Thibault, O.;Hadley, R.;Landfield, P.W. "Elevated postsynaptic Ca2+ i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity." The Journal of neuroscience : the official journal of the Society for Neuroscience 21, 24 (2001): 9744-56. [PubMed Link] | [ Full text ]
  • Chen, K.C.;Blalock, E.M.;Thibault, O.;Kaminker, P.;Landfield, P.W. "Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices." Proceedings of the National Academy of Sciences of the United States of America 97, 8 (2000): 4357-62. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures." The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 19 (1999): 8674-84. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Cadwallader-Neal, L. "Long-term treatment with calcitriol (1,25(OH)2 vit D3) retards a biomarker of hippocampal aging in rats." Neurobiology of aging 19, 5 (1998): 469-77. [PubMed Link] | [ Full text ]
  • Herman, J.P.;Chen, K.C.;Booze, R.;Landfield, P.W. "Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats." Neurobiology of aging 19, 6 (1998): 581-7. [PubMed Link] | [ Full text ]
  • Thibault, O.;Porter, N.M.;Chen, K.C.;Blalock, E.M.;Kaminker, P.G.;Clodfelter, G.V.;Brewer, L.D.;Landfield, P.W. "Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions." Cell calcium 24, 5-6 (1998): 417-33. [PubMed Link] |
  • Porter, N.M.;Landfield, P.W. "Stress hormones and brain aging: adding injury to insult?" Nature neuroscience 1, 1 (1998): 3-4. [PubMed Link] | [ Full text ]
  • Smith, C.D.;Landrum, W.;Carney, J.M.;Landfield, P.W.;Avison, M.J. "Brain creatine kinase with aging in F-344 rats: analysis by saturation transfer magnetic resonance spectroscopy." Neurobiology of aging 18, 6 (1997): 617-22. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Thibault, O.;Thibault, V.;Chen, K.C.;Landfield, P.W. "Calcium channel density and hippocampal cell death with age in long-term culture." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 14 (1997): 5629-39. [PubMed Link] | [ Full text ]
  • Gallagher, M.;Landfield, P.W.;McEwen, B.;Meaney, M.J.;Rapp, P.R.;Sapolsky, R.;West, M.J. "Hippocampal neurodegeneration in aging." Science (New York, N.Y.) 274, 5287 (1996): 484-5. [PubMed Link] | [ Full text ]
  • Campbell, L.W.;Hao, S.Y.;Thibault, O.;Blalock, E.M.;Landfield, P.W. "Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 16, 19 (1996): 6286-95. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;McEwen, B.S.;Sapolsky, R.M.;Meaney, M.J. "Hippocampal cell death." Science (New York, N.Y.) 272, 5266 (1996): 1249b-51b. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;McEwan, B.S.;Sapolsky, R.M.;Meaney, M.J. "Hippocampal cell death." Science (New York, N.Y.) 272, 5266 (1996): 1249-51. [PubMed Link] |
  • Thibault, O.;Landfield, P.W. "Increase in single L-type calcium channels in hippocampal neurons during aging." Science (New York, N.Y.) 272, 5264 (1996): 1017-20. [PubMed Link] | [ Full text ]
  • Landfield, P.W. "Aging-related increase in hippocampal calcium channels." Life sciences 59, 5-6 (1996): 399-404. [PubMed Link] |
  • Thibault, O.;Mazzanti, M.L.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons." Journal of neuroscience methods 59, 1 (1995): 77-83. [PubMed Link] | [ Full text ]
  • Lipton, P.;Aitken, P.G.;Dudek, F.E.;Eskessen, K.;Espanol, M.T.;Ferchmin, P.A.;Kelly, J.B.;Kreisman, N.R.;Landfield, P.W.;Larkman, P.M. "Making the best of brain slices: comparing preparative methods." Journal of neuroscience methods 59, 1 (1995): 151-6. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Eldridge, J.C. "The glucocorticoid hypothesis of age-related hippocampal neurodegeneration: role of dysregulated intraneuronal calcium." Annals of the New York Academy of Sciences 746, (1994): 308-21; discussion 321-6. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Eldridge, J.C. "Evolving aspects of the glucocorticoid hypothesis of brain aging: hormonal modulation of neuronal calcium homeostasis." Neurobiology of aging 15, 4 (1994): 579-88. [PubMed Link] |
  • Landfield, P.W. "Nathan Shock Memorial Lecture 1990. The role of glucocorticoids in brain aging and Alzheimer's disease: an integrative physiological hypothesis." Experimental gerontology 29, 1 (1994): 3-11. [PubMed Link] |
  • Landfield, P.W. "Increased hippocampal Ca2+ channel activity in brain aging and dementia. Hormonal and pharmacologic modulation." Annals of the New York Academy of Sciences 747, (1994): 351-64. [PubMed Link] | [ Full text ]
  • Thibault, O.;Porter, N.M.;Landfield, P.W. "Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications." Proceedings of the National Academy of Sciences of the United States of America 90, 24 (1993): 11792-6. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Eldridge, J.C. "Neurotoxicity and drugs of abuse: cannabinoid interaction with brain glucocorticoid receptors." NIDA research monograph 136, (1993): 242-56; discussion 256-7. [PubMed Link] |
  • Kerr, D.S.;Campbell, L.W.;Thibault, O.;Landfield, P.W. "Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging." Proceedings of the National Academy of Sciences of the United States of America 89, 18 (1992): 8527-31. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Thibault, O.;Mazzanti, M.L.;Porter, N.M.;Kerr, D.S. "Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis." Journal of neurobiology 23, 9 (1992): 1247-60. [PubMed Link] |
  • O'Steen, W.K.;Landfield, P.W. "Dietary restriction does not alter retinal aging in the Fischer 344 rat." Neurobiology of aging 12, 5 (1991): 455-62. [PubMed Link] |
  • Kerr, D.S.;Campbell, L.W.;Applegate, M.D.;Brodish, A.;Landfield, P.W. "Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging." The Journal of neuroscience : the official journal of the Society for Neuroscience 11, 5 (1991): 1316-24. [PubMed Link] | [ Full text ]
  • Eldridge, J.C.;Murphy, L.L.;Landfield, P.W. "Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance." Steroids 56, 5 (1991): 226-31. [PubMed Link] |
  • Landfield, P.W.;Applegate, M.D.;Schmitzer-Osborne, S.E.;Naylor, C.E. "Phosphate/calcium alterations in the first stages of Alzheimer's disease: implications for etiology and pathogenesis." Journal of the neurological sciences 106, 2 (1991): 221-9. [PubMed Link] |
  • Landfield, P.W.;Eldridge, J.C. "The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications." Acta endocrinologica 125 Suppl 1, (1991): 54-64. [PubMed Link] | [ Full text ]
  • Eldridge, J.C.;Landfield, P.W. "Cannabinoid interactions with glucocorticoid receptors in rat hippocampus." Brain research 534, 1-2 (1990): 135-41. [PubMed Link] | [ Full text ]
  • Pitler, T.A.;Landfield, P.W. "Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons." Brain research 508, 1 (1990): 1-6. [PubMed Link] | [ Full text ]
  • Kerr, D.S.;Campbell, L.W.;Hao, S.Y.;Landfield, P.W. "Corticosteroid modulation of hippocampal potentials: increased effect with aging." Science (New York, N.Y.) 245, 4925 (1989): 1505-9. [PubMed Link] | [ Full text ]
  • Eldridge, J.C.;Brodish, A.;Kute, T.E.;Landfield, P.W. "Apparent age-related resistance of type II hippocampal corticosteroid receptors to down-regulation during chronic escape training." The Journal of neuroscience : the official journal of the Society for Neuroscience 9, 9 (1989): 3237-42. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Eldridge, J.C. "Increased affinity of type II corticosteroid binding in aged rat hippocampus." Experimental neurology 106, 1 (1989): 110-3. [PubMed Link] | [ Full text ]
  • Eldridge, J.C.;Fleenor, D.G.;Kerr, D.S.;Landfield, P.W. "Impaired up-regulation of type II corticosteroid receptors in hippocampus of aged rats." Brain research 478, 2 (1989): 248-56. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Campbell, L.W.;Hao, S.Y.;Kerr, D.S. "Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease." Annals of the New York Academy of Sciences 568, (1989): 95-105. [PubMed Link] | [ Full text ]
  • Landfield, P.W. "Hippocampal neurobiological mechanisms of age-related memory dysfunction." Neurobiology of aging 9, 5-6 (1988): 571-9. [PubMed Link] |
  • Landfield, P.W.;Cadwallader, L.B.;Vinsant, S. "Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems." Brain research 443, 1-2 (1988): 47-62. [PubMed Link] | [ Full text ]
  • Applegate, M.D.;Landfield, P.W. "Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats." The Journal of neuroscience : the official journal of the Society for Neuroscience 8, 4 (1988): 1096-111. [PubMed Link] | [ Full text ]
  • Landfield, P.W. "Commentary on biomarkers of aging in the nervous system." Experimental gerontology 23, 4-5 (1988): 413-6. [PubMed Link] |
  • Pitler, T.A.;Landfield, P.W. "Postsynaptic membrane shifts during frequency potentiation of the hippocampal EPSP." Journal of neurophysiology 58, 4 (1987): 866-82. [PubMed Link] | [ Full text ]
  • Landfield, P.W. "'Increased calcium-current' hypothesis of brain aging." Neurobiology of aging 8, 4 (1987): 346-7. [PubMed Link] | [ Full text ]
  • Applegate, M.D.;Kerr, D.S.;Landfield, P.W. "Redistribution of synaptic vesicles during long-term potentiation in the hippocampus." Brain research 401, 2 (1987): 401-6. [PubMed Link] | [ Full text ]
  • Pitler, T.A.;Landfield, P.W. "Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons." Brain research 410, 1 (1987): 147-53. [PubMed Link] | [ Full text ]
  • Landfield, P.W. "Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides." Progress in brain research 72, (1987): 279-300. [PubMed Link] |
  • Landfield, P.W. "Delta-9-tetrahydrocannabinol-dependent alterations in brain structure." NIDA research monograph 78, (1987): 143-57. [PubMed Link] |
  • Landfield, P.W.;Pitler, T.A.;Applegate, M.D. "The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats." Journal of neurophysiology 56, 3 (1986): 797-811. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Pitler, T.A. "Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats." Science (New York, N.Y.) 226, 4678 (1984): 1089-92. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Morgan, G.A. "Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats." Brain research 322, 1 (1984): 167-71. [PubMed Link] | [ Full text ]
  • Poole, L.B.;Liu, M.S.;Landfield, P.W. "Kinetic studies of the Na+-K+-ATPase enzyme system in brain and heart of aging rats." The American journal of physiology 247, 5 Pt 2 (1984): R850-5. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Braun, L.D.;Pitler, T.A.;Lindsey, J.D.;Lynch, G. "Hippocampal aging in rats: a morphometric study of multiple variables in semithin sections." Neurobiology of aging 2, 4 (1981): 265-75. [PubMed Link] |
  • Landfield, P.W.;Baskin, R.K.;Pitler, T.A. "Brain aging correlates: retardation by hormonal-pharmacological treatments." Science (New York, N.Y.) 214, 4520 (1981): 581-4. [PubMed Link] | [ Full text ]
  • Lindsey, J.D.;Landfield, P.W.;Lynch, G. "Early onset and topographical distribution of hypertrophied astrocytes in hippocampus of aging rats: a quantitative study." Journal of gerontology 34, 5 (1979): 661-71. [PubMed Link] |
  • Landfield, P.W.;Wurtz, C.;Lindsey, J.D. "Quantification of synaptic vesicles in hippocampus of aging rats and initial studies of possible relations to neurophysiology." Brain research bulletin 4, 6 (1979): 757-63. [PubMed Link] |
  • Landfield, P.W.;McGaugh, J.L.;Lynch, G. "Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats." Brain research 150, 1 (1978): 85-101. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Waymire, J.C.;Lynch, G. "Hippocampal aging and adrenocorticoids: quantitative correlations." Science (New York, N.Y.) 202, 4372 (1978): 1098-102. [PubMed Link] | [ Full text ]
  • Landfield, P.W. "An endocrine hypothesis of brain aging and studies on brain-endocrine correlations and monosynaptic neurophysiology during aging." Advances in experimental medicine and biology 113, (1978): 179-99. [PubMed Link] |
  • Landfield, P.W.;Lynch, G. "Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats." Journal of gerontology 32, 5 (1977): 523-33. [PubMed Link] |
  • Landfield, P.W.;Rose, G.;Sandles, L.;Wohlstadter, T.C.;Lynch, G. "Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats." Journal of gerontology 32, 1 (1977): 3-12. [PubMed Link] |
  • Landfield, P.W. "Computer-determined EEG patterns associated with memory-facilitating drugs and with ECS." Brain research bulletin 1, 1 (1976): 9-17. [PubMed Link] |
  • Landfield, P.W.;Tusa, R.J.;McGaugh, J.L. "Effects of posttrial hippocampal stimulation on memory storage and EEG activity." Behavioral biology 8, 4 (1973): 485-505. [PubMed Link] |
  • McGaugh, J.L.;Zornetzer, S.F.;Gold, P.E.;Landfield, P.W. "Modification of memory systems: some neurobiological aspects." Quarterly reviews of biophysics 5, 2 (1972): 163-86. [PubMed Link] |
  • Landfield, P.W.;McGaugh, J.L.;Tusa, R.J. "Theta rhythm: a temporal correlate of memory storage processes in the rat." Science (New York, N.Y.) 175, 4017 (1972): 87-9. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;McGaugh, J.L. "Effects of electroconvulsive shock and brain stimulation on EEG cortical theta rhythms in rats." Behavioral biology 7, 2 (1972): 271-8. [PubMed Link] |
  • McGaugh, J.L.;Landfield, P.W. "Delayed development of amnesia following electroconvulsive shock." Physiology & behavior 5, 10 (1970): 1109-13. [PubMed Link] | [ Full text ]
  • Denti, A.;McGaugh, J.L.;Landfield, P.W.;Shinkman, P.G. "Effects of posttrial electrical stimulation on the mesencephalic reticular formation on avoidance learning in rats." Physiology & behavior 5, 6 (1970): 659-62. [PubMed Link] |