Philip A. Kern, M.D.

PubMed Publications: 

  • Finlin, B.S.;Zhu, B.;Confides, A.L.;Westgate, P.M.;Harfmann, B.D.;Dupont-Versteegden, E.E.;Kern, P.A. "Mast Cells Promote Seasonal White Adipose Beiging in Humans." Diabetes (2017): [PubMed Link] | [ Full text ]
  • Murach, K.A.;Walton, R.G.;Fry, C.S.;Michaelis, S.L.;Groshong, J.S.;Finlin, B.S.;Kern, P.A.;Peterson, C.A. "Cycle training modulates satellite cell and transcriptional responses to a bout of resistance exercise." Physiological reports 4, 18 (2016): [PubMed Link] | [ Full text ]
  • Park, S.H.;Liu, Z.;Sui, Y.;Helsley, R.N.;Zhu, B.;Powell, D.K.;Kern, P.A.;Zhou, C. "IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity." Diabetes 65, 6 (2016): 1616-29. [PubMed Link] | [ Full text ]
  • Helsley, R.N.;Sui, Y.;Park, S.H.;Liu, Z.;Lee, R.G.;Zhu, B.;Kern, P.A.;Zhou, C. "Targeting IκB kinase β in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions." Stem cells (Dayton, Ohio) 34, 7 (2016): 1883-95. [PubMed Link] | [ Full text ]
  • Kirby, T.J.;Walton, R.G.;Finlin, B.;Zhu, B.;Unal, R.;Rasouli, N.;Peterson, C.A.;Kern, P.A. "Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue." Physiological genomics 48, 2 (2016): 145-53. [PubMed Link] | [ Full text ]
  • Lawler, H.M.;Underkofler, C.M.;Kern, P.A.;Erickson, C.;Bredbeck, B.;Rasouli, N. "Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects." The Journal of clinical endocrinology and metabolism 101, 4 (2016): 1422-8. [PubMed Link] | [ Full text ]
  • Adams, D.;Kern, P.A. "A case of pituitary abscess presenting without a source of infection or prior pituitary pathology." Endocrinology, diabetes & metabolism case reports 2016, (2016): [PubMed Link] |
  • Walton, R.G.;Zhu, B.;Unal, R.;Spencer, M.;Sunkara, M.;Morris, A.J.;Charnigo, R.;Katz, W.S.;Daugherty, A.;Howatt, D.A.;Kern, P.A.;Finlin, B.S. "Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity." The Journal of biological chemistry 290, 18 (2015): 11547-56. [PubMed Link] | [ Full text ]
  • Maturu, A.;DeWitt, P.;Kern, P.A.;Rasouli, N. "The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of β-cell function in African American women." Metabolism: clinical and experimental 64, 5 (2015): 561-5. [PubMed Link] | [ Full text ]
  • Walton, R.G.;Finlin, B.S.;Mula, J.;Long, D.E.;Zhu, B.;Fry, C.S.;Westgate, P.M.;Lee, J.D.;Bennett, T.;Kern, P.A.;Peterson, C.A. "Insulin-resistant subjects have normal angiogenic response to aerobic exercise training in skeletal muscle, but not in adipose tissue." Physiological reports 3, 6 (2015): [PubMed Link] | [ Full text ]
  • Arble, D.M.;Bass, J.;Behn, C.D.;Butler, M.P.;Challet, E.;Czeisler, C.;Depner, C.M.;Elmquist, J.;Franken, P.;Grandner, M.A.;Hanlon, E.C.;Keene, A.C.;Joyner, M.J.;Karatsoreos, I.;Kern, P.A.;Klein, S.;Morris, C.J.;Pack, A.I.;Panda, S.;Ptacek, L.J.;Punjabi, N.M.;Sassone-Corsi, P.;Scheer, F.A.;Saxena, R.;Seaquest, E.R.;Thimgan, M.S.;Van Cauter, E.;Wright, K.P. "Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions." Sleep 38, 12 (2015): 1849-60. [PubMed Link] | [ Full text ]
  • Nagarajan, R.;Peterson, C.A.;Lowe, J.S.;Wyatt, S.W.;Tracy, T.S.;Kern, P.A. "Social network analysis to assess the impact of the CTSA on biomedical research grant collaboration." Clinical and translational science 8, 2 (2015): 150-4. [PubMed Link] | [ Full text ]
  • Fry, C.S.;Noehren, B.;Mula, J.;Ubele, M.F.;Westgate, P.M.;Kern, P.A.;Peterson, C.A. "Fibre type-specific satellite cell response to aerobic training in sedentary adults." The Journal of physiology 592, 12 (2014): 2625-35. [PubMed Link] | [ Full text ]
  • Spencer, M.;Yang, L.;Adu, A.;Finlin, B.S.;Zhu, B.;Shipp, L.R.;Rasouli, N.;Peterson, C.A.;Kern, P.A. "Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity." PloS one 9, 7 (2014): e102190. [PubMed Link] | [ Full text ]
  • Hodakoski, C.;Hopkins, B.D.;Barrows, D.;Mense, S.M.;Keniry, M.;Anderson, K.E.;Kern, P.A.;Hawkins, P.T.;Stephens, L.R.;Parsons, R. "Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis." Proceedings of the National Academy of Sciences of the United States of America 111, 1 (2014): 155-60. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Finlin, B.S.;Zhu, B.;Rasouli, N.;McGehee RE, J.;Westgate, P.M.;Dupont-Versteegden, E.E. "The effects of temperature and seasons on subcutaneous white adipose tissue in humans: evidence for thermogenic gene induction." The Journal of clinical endocrinology and metabolism 99, 12 (2014): E2772-9. [PubMed Link] | [ Full text ]
  • Finlin, B.S.;Zhu, B.;Starnes, C.P.;McGehee RE, J.;Peterson, C.A.;Kern, P.A. "Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids." The Journal of nutritional biochemistry 24, 9 (2013): 1571-9. [PubMed Link] | [ Full text ]
  • Spencer, M.;Finlin, B.S.;Unal, R.;Zhu, B.;Morris, A.J.;Shipp, L.R.;Lee, J.;Walton, R.G.;Adu, A.;Erfani, R.;Campbell, M.;McGehee RE, J.;Peterson, C.A.;Kern, P.A. "Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance." Diabetes 62, 5 (2013): 1709-17. [PubMed Link] | [ Full text ]
  • Ma, L.;Murea, M.;Snipes, J.A.;Marinelarena, A.;Krüger, J.;Hicks, P.J.;Langberg, K.A.;Bostrom, M.A.;Cooke, J.N.;Suzuki, D.;Babazono, T.;Uzu, T.;Tang, S.C.;Mondal, A.K.;Sharma, N.K.;Kobes, S.;Antinozzi, P.A.;Davis, M.;Das, S.K.;Rasouli, N.;Kern, P.A.;Shores, N.J.;Rudel, L.L.;Blüher, M.;Stumvoll, M.;Bowden, D.W.;Maeda, S.;Parks, J.S.;Kovacs, P.;Hanson, R.L.;Baier, L.J.;Elbein, S.C.;Freedman, B.I. "An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects." PloS one 8, 2 (2013): e56193. [PubMed Link] | [ Full text ]
  • Elbein, S.C.;Gamazon, E.R.;Das, S.K.;Rasouli, N.;Kern, P.A.;Cox, N.J. "Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?" American journal of human genetics 91, 3 (2012): 466-77. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Unal, R.;Pokrovskaya, I.D.;Tripathi, P.;Rotter, J.I.;Goodarzi, M.O.;Kern, P.A. "The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation." Atherosclerosis 221, 1 (2012): 143-7. [PubMed Link] | [ Full text ]
  • Rasouli, N.;Kern, P.A.;Elbein, S.C.;Sharma, N.K.;Das, S.K. "Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts." Pharmacogenetics and genomics 22, 7 (2012): 484-97. [PubMed Link] | [ Full text ]
  • Finlin, B.S.;Bodles-Brakhop, A.M.;Yao-Borengasser, A.;Zhu, B.;Starnes, C.P.;McGehee RE, J.;Peterson, C.A.;Kern, P.A.;Rasouli, N. "Regulation of small ubiquitin-like modifier-1, nuclear receptor coreceptor, histone deacetylase 3, and peroxisome proliferator-activated receptor-γ in human adipose tissue." Metabolic syndrome and related disorders 10, 4 (2012): 312-7. [PubMed Link] |
  • Finlin, B.S.;Varma, V.;Nolen, G.T.;Dubé, J.;Starnes, C.P.;Rasouli, N.;Kern, P.A.;Peterson, C.A. "DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages." The Journal of nutritional biochemistry 23, 8 (2012): 885-91. [PubMed Link] | [ Full text ]
  • Elbein, S.C.;Kern, P.A.;Rasouli, N.;Yao-Borengasser, A.;Sharma, N.K.;Das, S.K. "Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI." Diabetes 60, 3 (2011): 1019-29. [PubMed Link] | [ Full text ]
  • Yao-Borengasser, A.;Varma, V.;Coker, R.H.;Ranganathan, G.;Phanavanh, B.;Rasouli, N.;Kern, P.A. "Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone." Metabolism: clinical and experimental 60, 7 (2011): 1012-20. [PubMed Link] | [ Full text ]
  • Spencer, M.;Unal, R.;Zhu, B.;Rasouli, N.;McGehee RE, J.;Peterson, C.A.;Kern, P.A. "Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance." The Journal of clinical endocrinology and metabolism 96, 12 (2011): E1990-8. [PubMed Link] | [ Full text ]
  • Zhang, H.;Xie, C.;Spencer, H.J.;Zuo, C.;Higuchi, M.;Ranganathan, G.;Kern, P.A.;Chou, M.W.;Huang, Q.;Szczesny, B.;Mitra, S.;Watson, A.J.;Margison, G.P.;Fan, C.Y. "Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria." The American journal of pathology 178, 4 (2011): 1715-27. [PubMed Link] | [ Full text ]
  • Smith, L.M.;Yao-Borengasser, A.;Starks, T.;Tripputi, M.;Kern, P.A.;Rasouli, N. "Insulin resistance in African-American and Caucasian women: differences in lipotoxicity, adipokines, and gene expression in adipose tissue and muscle." The Journal of clinical endocrinology and metabolism 95, 9 (2010): 4441-8. [PubMed Link] | [ Full text ]
  • Unal, R.;Yao-Borengasser, A.;Varma, V.;Rasouli, N.;Labbate, C.;Kern, P.A.;Ranganathan, G. "Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone." The Journal of clinical endocrinology and metabolism 95, 6 (2010): 2993-3001. [PubMed Link] | [ Full text ]
  • Spencer, M.;Yao-Borengasser, A.;Unal, R.;Rasouli, N.;Gurley, C.M.;Zhu, B.;Peterson, C.A.;Kern, P.A. "Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation." American journal of physiology. Endocrinology and metabolism 299, 6 (2010): E1016-27. [PubMed Link] | [ Full text ]
  • Rasouli, N.;Yao-Borengasser, A.;Varma, V.;Spencer, H.J.;McGehee RE, J.;Peterson, C.A.;Mehta, J.L.;Kern, P.A. "Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans." Arteriosclerosis, thrombosis, and vascular biology 29, 9 (2009): 1328-35. [PubMed Link] | [ Full text ]
  • Coker, R.H.;Williams, R.H.;Yeo, S.E.;Kortebein, P.M.;Bodenner, D.L.;Kern, P.A.;Evans, W.J. "The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity." The Journal of clinical endocrinology and metabolism 94, 11 (2009): 4258-66. [PubMed Link] | [ Full text ]
  • Banga, A.;Unal, R.;Tripathi, P.;Pokrovskaya, I.;Owens, R.J.;Kern, P.A.;Ranganathan, G. "Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids." American journal of physiology. Endocrinology and metabolism 296, 3 (2009): E480-9. [PubMed Link] | [ Full text ]
  • Varma, V.;Yao-Borengasser, A.;Rasouli, N.;Nolen, G.T.;Phanavanh, B.;Starks, T.;Gurley, C.;Simpson, P.;McGehee RE, J.;Kern, P.A.;Peterson, C.A. "Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action." American journal of physiology. Endocrinology and metabolism 296, 6 (2009): E1300-10. [PubMed Link] | [ Full text ]
  • Coker, R.H.;Williams, R.H.;Yeo, S.E.;Kortebein, P.M.;Bodenner, D.L.;Kern, P.A.;Evans, W.J. "Visceral fat and adiponectin: associations with insulin resistance are tissue-specific in women." Metabolic syndrome and related disorders 7, 1 (2009): 61-7. [PubMed Link] |
  • Rasouli, N.;Kern, P.A. "Adipocytokines and the metabolic complications of obesity." The Journal of clinical endocrinology and metabolism 93, 11 Suppl 1 (2008): S64-73. [PubMed Link] | [ Full text ]
  • Sharma, N.K.;Das, S.K.;Mondal, A.K.;Hackney, O.G.;Chu, W.S.;Kern, P.A.;Rasouli, N.;Spencer, H.J.;Yao-Borengasser, A.;Elbein, S.C. "Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects." The Journal of clinical endocrinology and metabolism 93, 11 (2008): 4532-41. [PubMed Link] | [ Full text ]
  • Yao-Borengasser, A.;Rassouli, N.;Varma, V.;Bodles, A.M.;Rasouli, N.;Unal, R.;Phanavanh, B.;Ranganathan, G.;McGehee RE, J.;Kern, P.A. "Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness." The Journal of clinical endocrinology and metabolism 93, 11 (2008): 4431-9. [PubMed Link] | [ Full text ]
  • Banga, A.;Bodles, A.M.;Rasouli, N.;Ranganathan, G.;Kern, P.A.;Owens, R.J. "Calcium is involved in formation of high molecular weight adiponectin." Metabolic syndrome and related disorders 6, 2 (2008): 103-11. [PubMed Link] |
  • Unal, R.;Pokrovskaya, I.;Tripathi, P.;Monia, B.P.;Kern, P.A.;Ranganathan, G. "Translational regulation of lipoprotein lipase in adipocytes: depletion of cellular protein kinase Calpha activates binding of the C subunit of protein kinase A to the 3'-untranslated region of the lipoprotein lipase mRNA." The Biochemical journal 413, 2 (2008): 315-22. [PubMed Link] | [ Full text ]
  • Varma, V.;Yao-Borengasser, A.;Bodles, A.M.;Rasouli, N.;Phanavanh, B.;Nolen, G.T.;Kern, E.M.;Nagarajan, R.;Spencer HJ, 3rd;Lee, M.J.;Fried, S.K.;McGehee RE, J.;Peterson, C.A.;Kern, P.A. "Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance." Diabetes 57, 2 (2008): 432-9. [PubMed Link] | [ Full text ]
  • Das, S.K.;Chu, W.S.;Mondal, A.K.;Sharma, N.K.;Kern, P.A.;Rasouli, N.;Elbein, S.C. "Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines." American journal of physiology. Endocrinology and metabolism 295, 2 (2008): E393-400. [PubMed Link] | [ Full text ]
  • Yao-Borengasser, A.;Varma, V.;Bodles, A.M.;Rasouli, N.;Phanavanh, B.;Lee, M.J.;Starks, T.;Kern, L.M.;Spencer HJ, 3rd;Rashidi, A.A.;McGehee RE, J.;Fried, S.K.;Kern, P.A. "Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone." The Journal of clinical endocrinology and metabolism 92, 7 (2007): 2590-7. [PubMed Link] | [ Full text ]
  • Rasouli, N.;Molavi, B.;Elbein, S.C.;Kern, P.A. "Ectopic fat accumulation and metabolic syndrome." Diabetes, obesity & metabolism 9, 1 (2007): 1-10. [PubMed Link] | [ Full text ]
  • Rasouli, N.;Kern, P.A.;Reece, E.A.;Elbein, S.C. "Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes." American journal of physiology. Endocrinology and metabolism 292, 1 (2007): E359-65. [PubMed Link] | [ Full text ]
  • Liu, Z.;Aronson, J.;Wahl, E.C.;Liu, L.;Perrien, D.S.;Kern, P.A.;Fowlkes, J.L.;Thrailkill, K.M.;Bunn, R.C.;Cockrell, G.E.;Skinner, R.A.;Lumpkin CK, J. "A novel rat model for the study of deficits in bone formation in type-2 diabetes." Acta orthopaedica 78, 1 (2007): 46-55. [PubMed Link] | [ Full text ]
  • Varma, V.;Yao-Borengasser, A.;Rasouli, N.;Bodles, A.M.;Phanavanh, B.;Lee, M.J.;Starks, T.;Kern, L.M.;Spencer HJ, 3rd;McGehee RE, J.;Fried, S.K.;Kern, P.A. "Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation." The Journal of clinical endocrinology and metabolism 92, 2 (2007): 666-72. [PubMed Link] | [ Full text ]
  • Elbein, S.C.;Chu, W.S.;Das, S.K.;Yao-Borengasser, A.;Hasstedt, S.J.;Wang, H.;Rasouli, N.;Kern, P.A. "Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent." Diabetologia 50, 8 (2007): 1621-30. [PubMed Link] | [ Full text ]
  • Molavi, B.;Rasouli, N.;Kern, P.A. "The prevention and treatment of metabolic syndrome and high-risk obesity." Current opinion in cardiology 21, 5 (2006): 479-85. [PubMed Link] | [ Full text ]
  • Bodles, A.M.;Varma, V.;Yao-Borengasser, A.;Phanavanh, B.;Peterson, C.A.;McGehee RE, J.;Rasouli, N.;Wabitsch, M.;Kern, P.A. "Pioglitazone induces apoptosis of macrophages in human adipose tissue." Journal of lipid research 47, 9 (2006): 2080-8. [PubMed Link] | [ Full text ]
  • Yao-Borengasser, A.;Rasouli, N.;Varma, V.;Miles, L.M.;Phanavanh, B.;Starks, T.N.;Phan, J.;Spencer HJ, 3rd;McGehee RE, J.;Reue, K.;Kern, P.A. "Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation." Diabetes 55, 10 (2006): 2811-8. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Unal, R.;Pokrovskaya, I.;Yao-Borengasser, A.;Phanavanh, B.;Lecka-Czernik, B.;Rasouli, N.;Kern, P.A. "The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment." Journal of lipid research 47, 11 (2006): 2444-50. [PubMed Link] | [ Full text ]
  • Bodles, A.M.;Banga, A.;Rasouli, N.;Ono, F.;Kern, P.A.;Owens, R.J. "Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes." American journal of physiology. Endocrinology and metabolism 291, 5 (2006): E1100-5. [PubMed Link] | [ Full text ]
  • Rasouli, N.;Yao-Borengasser, A.;Miles, L.M.;Elbein, S.C.;Kern, P.A. "Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression." American journal of physiology. Endocrinology and metabolism 290, 1 (2006): E42-E46. [PubMed Link] | [ Full text ]
  • Wolins, N.E.;Quaynor, B.K.;Skinner, J.R.;Tzekov, A.;Croce, M.A.;Gropler, M.C.;Varma, V.;Yao-Borengasser, A.;Rasouli, N.;Kern, P.A.;Finck, B.N.;Bickel, P.E. "OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization." Diabetes 55, 12 (2006): 3418-28. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Pokrovskaya, I.;Ranganathan, S.;Kern, P.A. "Role of A kinase anchor proteins in the tissue-specific regulation of lipoprotein lipase." Molecular endocrinology (Baltimore, Md.) 19, 10 (2005): 2527-34. [PubMed Link] | [ Full text ]
  • Rasouli, N.;Raue, U.;Miles, L.M.;Lu, T.;Di Gregorio, G.B.;Elbein, S.C.;Kern, P.A. "Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue." American journal of physiology. Endocrinology and metabolism 288, 5 (2005): E930-4. [PubMed Link] | [ Full text ]
  • Di Gregorio, G.B.;Yao-Borengasser, A.;Rasouli, N.;Varma, V.;Lu, T.;Miles, L.M.;Ranganathan, G.;Peterson, C.A.;McGehee, R.E.;Kern, P.A. "Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone." Diabetes 54, 8 (2005): 2305-13. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Said, S.;Jackson WG, J.;Michalek, J.E. "Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin." The Journal of clinical endocrinology and metabolism 89, 9 (2004): 4665-72. [PubMed Link] | [ Full text ]
  • Di Gregorio, G.B.;Westergren, R.;Enerback, S.;Lu, T.;Kern, P.A. "Expression of FOXC2 in adipose and muscle and its association with whole body insulin sensitivity." American journal of physiology. Endocrinology and metabolism 287, 4 (2004): E799-803. [PubMed Link] | [ Full text ]
  • Yue, L.;Rasouli, N.;Ranganathan, G.;Kern, P.A.;Mazzone, T. "Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression." The Journal of biological chemistry 279, 46 (2004): 47626-32. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Di Gregorio, G.;Lu, T.;Rassouli, N.;Ranganathan, G. "Perilipin expression in human adipose tissue is elevated with obesity." The Journal of clinical endocrinology and metabolism 89, 3 (2004): 1352-8. [PubMed Link] | [ Full text ]
  • Di Gregorio, G.B.;Hensley, L.;Lu, T.;Ranganathan, G.;Kern, P.A. "Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity." American journal of physiology. Endocrinology and metabolism 287, 1 (2004): E182-7. [PubMed Link] | [ Full text ]
  • Wang, H.;Chu, W.S.;Lu, T.;Hasstedt, S.J.;Kern, P.A.;Elbein, S.C. "Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion." American journal of physiology. Endocrinology and metabolism 286, 1 (2004): E1-7. [PubMed Link] | [ Full text ]
  • Fonseca, V.A.;Fink, L.M.;Kern, P.A. "Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects." Atherosclerosis 167, 1 (2003): 105-9. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Di Gregorio, G.B.;Lu, T.;Rassouli, N.;Ranganathan, G. "Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression." Diabetes 52, 7 (2003): 1779-85. [PubMed Link] | [ Full text ]
  • Freundl, G.;Godehardt, E.;Kern, P.A.;Frank-Herrmann, P.;Koubenec, H.J.;Gnoth, C. "Estimated maximum failure rates of cycle monitors using daily conception probabilities in the menstrual cycle." Human reproduction (Oxford, England) 18, 12 (2003): 2628-33. [PubMed Link] |
  • Hensley, L.L.;Ranganathan, G.;Wagner, E.M.;Wells, B.D.;Daniel, J.C.;Vu, D.;Semenkovich, C.F.;Zechner, R.;Kern, P.A. "Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation." The Journal of biological chemistry 278, 35 (2003): 32702-9. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Song, W.;Dean, N.;Monia, B.;Barger, S.W.;Kern, P.A. "Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes." The Journal of biological chemistry 277, 41 (2002): 38669-75. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Phan, D.;Pokrovskaya, I.D.;McEwen, J.E.;Li, C.;Kern, P.A. "The translational regulation of lipoprotein lipase by epinephrine involves an RNA binding complex including the catalytic subunit of protein kinase A." The Journal of biological chemistry 277, 45 (2002): 43281-7. [PubMed Link] | [ Full text ]
  • Ranganathan, S.;Kern, P.A. "The HIV protease inhibitor saquinavir impairs lipid metabolism and glucose transport in cultured adipocytes." The Journal of endocrinology 172, 1 (2002): 155-62. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Dicker-Brown, A.;Said, S.T.;Kennedy, R.;Fonseca, V.A. "The stimulation of tumor necrosis factor and inhibition of glucose transport and lipoprotein lipase in adipose cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Metabolism: clinical and experimental 51, 1 (2002): 65-8. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Fishman, R.B.;Song, W.;Brown, A.D.;Fonseca, V. "The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver." Toxicology 171, 2-3 (2002): 117-25. [PubMed Link] | [ Full text ]
  • Dicker-Brown, A.;Fonseca, V.A.;Fink, L.M.;Kern, P.A. "The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-beta-synthase: studies in hepatocytes." Atherosclerosis 158, 2 (2001): 297-301. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Ranganathan, S.;Li, C.;Wood, L.;Ranganathan, G. "Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance." American journal of physiology. Endocrinology and metabolism 280, 5 (2001): E745-51. [PubMed Link] | [ Full text ]
  • Fonseca, V.;Dicker-Brown, A.;Ranganathan, S.;Song, W.;Barnard, R.J.;Fink, L.;Kern, P.A. "Effects of a high-fat-sucrose diet on enzymes in homocysteine metabolism in the rat." Metabolism: clinical and experimental 49, 6 (2000): 736-41. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Li, C.;Kern, P.A. "The translational regulation of lipoprotein lipase in diabetic rats involves the 3'-untranslated region of the lipoprotein lipase mRNA." The Journal of biological chemistry 275, 52 (2000): 40986-91. [PubMed Link] | [ Full text ]
  • Cranmer, M.;Louie, S.;Kennedy, R.H.;Kern, P.A.;Fonseca, V.A. "Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance." Toxicological sciences : an official journal of the Society of Toxicology 56, 2 (2000): 431-6. [PubMed Link] |
  • Querfeld, U.;Hoffmann, M.M.;Klaus, G.;Eifinger, F.;Ackerschott, M.;Michalk, D.;Kern, P.A. "Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes." Journal of the American Society of Nephrology : JASN 10, 10 (1999): 2158-64. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Simsolo, R.B.;Fournier, M. "Effect of weight loss on muscle fiber type, fiber size, capillarity, and succinate dehydrogenase activity in humans." The Journal of clinical endocrinology and metabolism 84, 11 (1999): 4185-90. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Kaakaji, R.;Kern, P.A. "Role of protein kinase C in the translational regulation of lipoprotein lipase in adipocytes." The Journal of biological chemistry 274, 13 (1999): 9122-7. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Kern, P.A. "In vitro transcription and translation of lipoprotein lipase." Methods in molecular biology (Clifton, N.J.) 109, (1999): 337-41. [PubMed Link] |
  • Ranganathan, G.;Kern, P.A. "Techniques for the measurement of lipoprotein lipase messenger RNA." Methods in molecular biology (Clifton, N.J.) 109, (1999): 329-35. [PubMed Link] |
  • Ranganathan, S.;Kern, P.A. "Thiazolidinediones inhibit lipoprotein lipase activity in adipocytes." The Journal of biological chemistry 273, 40 (1998): 26117-22. [PubMed Link] | [ Full text ]
  • Ranganathan, S.;Ciaraldi, T.P.;Henry, R.R.;Mudaliar, S.;Kern, P.A. "Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells." Endocrinology 139, 5 (1998): 2509-13. [PubMed Link] | [ Full text ]
  • Fonseca, V.A.;Mudaliar, S.;Schmidt, B.;Fink, L.M.;Kern, P.A.;Henry, R.R. "Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects." Metabolism: clinical and experimental 47, 6 (1998): 686-9. [PubMed Link] |
  • Ciaraldi, T.P.;Carter, L.;Mudaliar, S.;Kern, P.A.;Henry, R.R. "Effects of Tumor Necrosis Factor-α on Glucose Metabolism in Cultured Human Muscle Cells from Nondiabetic and Type 2 Diabetic Subjects* * This work was supported by funds from the American Diabetes Association, the Whittier Institute for Diabetes..." Endocrinology 139, 12 (1998): 4793-4800. [PubMed Link] | [ Full text ]
  • Ciaraldi, T.P.;Carter, L.;Mudaliar, S.;Kern, P.A.;Henry, R.R. "Effects of tumor necrosis factor-alpha on glucose metabolism in cultured human muscle cells from nondiabetic and type 2 diabetic subjects." Endocrinology 139, 12 (1998): 4793-800. [PubMed Link] | [ Full text ]
  • Ranganathan, S.;Maffei, M.;Kern, P.A. "Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNFalpha expression." Journal of lipid research 39, 4 (1998): 724-30. [PubMed Link] | [ Full text ]
  • Kern, P.A. "Potential role of TNFalpha and lipoprotein lipase as candidate genes for obesity." The Journal of nutrition 127, 9 (1997): 1917S-1922S. [PubMed Link] | [ Full text ]
  • Kern, P.A. "A prudent and practical approach to the treatment of obesity." The Journal of the Arkansas Medical Society 94, 5 (1997): 191-7. [PubMed Link] |
  • Maheux, P.;Azhar, S.;Kern, P.A.;Chen, Y.D.;Reuven, G.M. "Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase." Diabetologia 40, 7 (1997): 850-8. [PubMed Link] |
  • Ranganathan, G.;Vu, D.;Kern, P.A. "Translational regulation of lipoprotein lipase by epinephrine involves a trans-acting binding protein interacting with the 3' untranslated region." The Journal of biological chemistry 272, 4 (1997): 2515-9. [PubMed Link] | [ Full text ]
  • Choi, S.Y.;Pang, L.;Kern, P.A.;Kayden, H.J.;Curtiss, L.K.;Vanni-Reyes, T.M.;Goldberg, I.J. "Dissociation of LPL and LDL: effects of lipoproteins and anti-apoB antibodies." Journal of lipid research 38, 1 (1997): 77-85. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Ranganathan, G.;Yukht, A.;Ong, J.M.;Davis, R.C. "Translational regulation of lipoprotein lipase by thyroid hormone is via a cytoplasmic repressor that interacts with the 3' untranslated region." Journal of lipid research 37, 11 (1996): 2332-40. [PubMed Link] | [ Full text ]
  • Vu, D.;Ong, J.M.;Clemens, T.L.;Kern, P.A. "1,25-Dihydroxyvitamin D induces lipoprotein lipase expression in 3T3-L1 cells in association with adipocyte differentiation." Endocrinology 137, 5 (1996): 1540-4. [PubMed Link] | [ Full text ]
  • Saghizadeh, M.;Ong, J.M.;Garvey, W.T.;Henry, R.R.;Kern, P.A. "The expression of TNF alpha by human muscle. Relationship to insulin resistance." The Journal of clinical investigation 97, 4 (1996): 1111-6. [PubMed Link] | [ Full text ]
  • Yukht, A.;Davis, R.C.;Ong, J.M.;Ranganathan, G.;Kern, P.A. "Regulation of lipoprotein lipase translation by epinephrine in 3T3-L1 cells. Importance of the 3' untranslated region." The Journal of clinical investigation 96, 5 (1995): 2438-44. [PubMed Link] | [ Full text ]
  • Simsolo, R.B.;Ezzat, S.;Ong, J.M.;Saghizadeh, M.;Kern, P.A. "Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase." The Journal of clinical endocrinology and metabolism 80, 11 (1995): 3233-8. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Saghizadeh, M.;Ong, J.M.;Bosch, R.J.;Deem, R.;Simsolo, R.B. "The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase." The Journal of clinical investigation 95, 5 (1995): 2111-9. [PubMed Link] | [ Full text ]
  • Ranganathan, G.;Ong, J.M.;Yukht, A.;Saghizadeh, M.;Simsolo, R.B.;Pauer, A.;Kern, P.A. "Tissue-specific expression of human lipoprotein lipase. Effect of the 3'-untranslated region on translation." The Journal of biological chemistry 270, 13 (1995): 7149-55. [PubMed Link] | [ Full text ]
  • Ong, J.M.;Simsolo, R.B.;Saghizadeh, M.;Goers, J.W.;Kern, P.A. "Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat." Metabolism: clinical and experimental 44, 12 (1995): 1596-605. [PubMed Link] |
  • Ong, J.M.;Simsolo, R.B.;Saghizadeh, M.;Pauer, A.;Kern, P.A. "Expression of lipoprotein lipase in rat muscle: regulation by feeding and hypothyroidism." Journal of lipid research 35, 9 (1994): 1542-51. [PubMed Link] | [ Full text ]
  • Slavin, B.G.;Ong, J.M.;Kern, P.A. "Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes." Journal of lipid research 35, 9 (1994): 1535-41. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Trozzolino, L.;Wolfe, G.;Purdy, L. "Combined use of behavior modification and very low-calorie diet in weight loss and weight maintenance." The American journal of the medical sciences 307, 5 (1994): 325-8. [PubMed Link] | [ Full text ]
  • Venkatesan, N.;Davidson, M.B.;Simsolo, R.B.;Kern, P.A. "Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat." Metabolism: clinical and experimental 43, 3 (1994): 348-56. [PubMed Link] |
  • Simsolo, R.B.;Ong, J.M.;Kern, P.A. "Effect of gemfibrozil on adipose tissue and muscle lipoprotein lipase." Metabolism: clinical and experimental 42, 11 (1993): 1486-91. [PubMed Link] | [ Full text ]
  • Simsolo, R.B.;Ong, J.M.;Kern, P.A. "The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining." The Journal of clinical investigation 92, 5 (1993): 2124-30. [PubMed Link] | [ Full text ]
  • Ong, J.M.;Saffari, B.;Simsolo, R.B.;Kern, P.A. "Epinephrine inhibits lipoprotein lipase gene expression in rat adipocytes through multiple steps in posttranscriptional processing." Molecular endocrinology (Baltimore, Md.) 6, 1 (1992): 61-9. [PubMed Link] | [ Full text ]
  • Simsolo, R.B.;Ong, J.M.;Saffari, B.;Kern, P.A. "Effect of improved diabetes control on the expression of lipoprotein lipase in human adipose tissue." Journal of lipid research 33, 1 (1992): 89-95. [PubMed Link] | [ Full text ]
  • Saffari, B.;Ong, J.M.;Kern, P.A. "Regulation of adipose tissue lipoprotein lipase gene expression by thyroid hormone in rats." Journal of lipid research 33, 2 (1992): 241-9. [PubMed Link] | [ Full text ]
  • Simsolo, R.B.;Ong, J.M.;Kern, P.A. "Characterization of lipoprotein lipase activity, secretion, and degradation at different sites of post-translational processing in primary cultures of rat adipocytes." Journal of lipid research 33, 12 (1992): 1777-84. [PubMed Link] | [ Full text ]
  • Ong, J.M.;Simsolo, R.B.;Saffari, B.;Kern, P.A. "The regulation of lipoprotein lipase gene expression by dexamethasone in isolated rat adipocytes." Endocrinology 130, 4 (1992): 2310-6. [PubMed Link] | [ Full text ]
  • Wallace, D.J.;Metzger, A.L.;Stecher, V.J.;Turnbull, B.A.;Kern, P.A. "Cholesterol-lowering effect of hydroxychloroquine in patients with rheumatic disease: reversal of deleterious effects of steroids on lipids." The American journal of medicine 89, 3 (1990): 322-6. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Martin, R.A.;Carty, J.;Goldberg, I.J.;Ong, J.M. "Identification of lipoprotein lipase immunoreactive protein in pre- and postheparin plasma from normal subjects and patients with type I hyperlipoproteinemia." Journal of lipid research 31, 1 (1990): 17-26. [PubMed Link] | [ Full text ]
  • Querfeld, U.;Ong, J.M.;Prehn, J.;Carty, J.;Saffari, B.;Jordan, S.C.;Kern, P.A. "Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages." Journal of lipid research 31, 8 (1990): 1379-86. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Ong, J.M.;Saffari, B.;Carty, J. "The effects of weight loss on the activity and expression of adipose-tissue lipoprotein lipase in very obese humans." The New England journal of medicine 322, 15 (1990): 1053-9. [PubMed Link] | [ Full text ]
  • Knedler, A.;Eckel, R.H.;Kern, P.A.;Ham, R.G. "Microvascular endothelial cell cultures from human omental adipose tissue." In vitro cellular & developmental biology : journal of the Tissue Culture Association 25, 10 (1989): 863-4. [PubMed Link] |
  • Kern, P.A.;Svoboda, M.E.;Eckel, R.H.;Van Wyk, J.J. "Insulinlike growth factor action and production in adipocytes and endothelial cells from human adipose tissue." Diabetes 38, 6 (1989): 710-7. [PubMed Link] | [ Full text ]
  • Ong, J.M.;Kern, P.A. "Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue." The Journal of clinical investigation 84, 1 (1989): 305-11. [PubMed Link] | [ Full text ]
  • Ong, J.M.;Kern, P.A. "The role of glucose and glycosylation in the regulation of lipoprotein lipase synthesis and secretion in rat adipocytes." The Journal of biological chemistry 264, 6 (1989): 3177-82. [PubMed Link] | [ Full text ]
  • Ong, J.M.;Kirchgessner, T.G.;Schotz, M.C.;Kern, P.A. "Insulin increases the synthetic rate and messenger RNA level of lipoprotein lipase in isolated rat adipocytes." The Journal of biological chemistry 263, 26 (1988): 12933-8. [PubMed Link] | [ Full text ]
  • Kern, P.A. "Recombinant human tumor necrosis factor does not inhibit lipoprotein lipase in primary cultures of isolated human adipocytes." Journal of lipid research 29, 7 (1988): 909-14. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Ong, J.M.;Goers, J.W.;Pedersen, M.E. "Regulation of lipoprotein lipase immunoreactive mass in isolated human adipocytes." The Journal of clinical investigation 81, 2 (1988): 398-406. [PubMed Link] | [ Full text ]
  • Goers, J.W.;Pedersen, M.E.;Kern, P.A.;Ong, J.;Schotz, M.C. "An enzyme-linked immunoassay for lipoprotein lipase." Analytical biochemistry 166, 1 (1987): 27-35. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Mandic, A.;Eckel, R.H. "Regulation of lipoprotein lipase by glucose in primary cultures of isolated human adipocytes. Relevance to hypertriglyceridemia of diabetes." Diabetes 36, 11 (1987): 1238-45. [PubMed Link] | [ Full text ]
  • Kern, P.A. "Lipid disorders in diabetes mellitus." The Mount Sinai journal of medicine, New York 54, 3 (1987): 245-52. [PubMed Link] |
  • Kern, P.A.;Robbins, R.J.;Bichet, D.;Berl, T.;Verbalis, J.G. "Syndrome of inappropriate antidiuresis in the absence of arginine vasopressin." The Journal of clinical endocrinology and metabolism 62, 1 (1986): 148-52. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Marshall, S.;Eckel, R.H. "Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes." The Journal of clinical investigation 75, 1 (1985): 199-208. [PubMed Link] | [ Full text ]
  • Robbins, R.J.;Kern, P.A.;Thompson TL, 2nd "Interactions between thioridazine and bromocriptine in a patient with a prolactin-secreting pituitary adenoma." The American journal of medicine 76, 5 (1984): 921-3. [PubMed Link] | [ Full text ]
  • Eckel, R.H.;Prasad, J.E.;Kern, P.A.;Marshall, S. "Insulin regulation of lipoprotein lipase in cultured isolated rat adipocytes." Endocrinology 114, 5 (1984): 1665-71. [PubMed Link] | [ Full text ]
  • Kern, P.A.;Knedler, A.;Eckel, R.H. "Isolation and culture of microvascular endothelium from human adipose tissue." The Journal of clinical investigation 71, 6 (1983): 1822-9. [PubMed Link] |
  • Kern, P.A.;Robbins, R.J. "Unilateral toxic multicystic goiter." Archives of internal medicine 143, 4 (1983): 834-5. [PubMed Link] | [ Full text ]