Olivier Thibault, Ph.D.

Bio / Education: 

1989-1993 Ph.D. in Neuroscience, Bowman Gray School of Medicine, Department of Anatomy.
1993-1995 Postdoctoral fellow, Dr. Philip Landfield, University of Kentucky, Department of Pharmacology.
1995-1997 Research Associate, University of Kentucky, Department of Pharmacology.
1998-2003 Research Assistant Professor, University of Kentucky, Department of Molecular and Biomedical Pharmacology
2004-2009 Assistant Professor, University of Kentucky, Department of Molecular and Biomedical Pharmacology
2009-2016 Associate Professor, University of Kentucky, Department of Pharmacology and Nutritional Sciences
2016-Present Professor, University of Kentucky, Department of Pharmacology and Nutritional Sciences

Research Description: 

Intersection of two fields: dysregulation of calcium-dependent cellular mechanisms of learning and memory with brain aging and links between peripheral metabolic dysregulation and cognitive decline.

Grants: 

Metabolic Syndrome and Hippocampal Calcium Dysregulation in Aging-related Cognitive Decline (NIA).

PubMed Publications: 

  • Xu, B.;Lefringhouse, J.;Liu, Z.;West, D.;Baldwin, L.A.;Ou, C.;Chen, L.;Napier, D.;Chaiswing, L.;Brewer, L.D.;St Clair, D.;Thibault, O.;Van Nagell, J.R.;Zhou, B.P.;Drapkin, R.;Huang, J.A.;Lu, M.L.;Ueland, F.R.;Yang, X.H. "Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy." Oncogenesis 6, 1 (2017): e295. [PubMed Link] | [ Full text ]
  • Frazier, H.N.;Maimaiti, S.;Anderson, K.L.;Brewer, L.D.;Gant, J.C.;Porter, N.M.;Thibault, O. "Calcium's role as nuanced modulator of cellular physiology in the brain." Biochemical and biophysical research communications 483, 4 (2017): 981-987. [PubMed Link] | [ Full text ]
  • Anderson, K.L.;Frazier, H.N.;Maimaiti, S.;Bakshi, V.V.;Majeed, Z.R.;Brewer, L.D.;Porter, N.M.;Lin, A.L.;Thibault, O. "Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism." The journals of gerontology. Series A, Biological sciences and medical sciences 72, 2 (2017): 189-197. [PubMed Link] | [ Full text ]
  • Griggs, R.B.;Donahue, R.R.;Adkins, B.G.;Anderson, K.L.;Thibault, O.;Taylor, B.K. "Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes." The journal of pain : official journal of the American Pain Society 17, 3 (2016): 359-73. [PubMed Link] | [ Full text ]
  • Maimaiti, S.;Anderson, K.L.;Demoll, C.;Brewer, L.D.;Rauh, B.A.;Gant, J.C.;Blalock, E.M.;Porter, N.M.;Thibault, O. "Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging." The journals of gerontology. Series A, Biological sciences and medical sciences 71, 1 (2016): 30-9. [PubMed Link] | [ Full text ]
  • Maimaiti, S.;Demoll, C.;Anderson, K.L.;Griggs, R.B.;Taylor, B.K.;Porter, N.M.;Thibault, O. "Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging." Brain research 1621, (2015): 214-21. [PubMed Link] | [ Full text ]
  • Zhou, P.;Erfani, S.;Liu, Z.;Jia, C.;Chen, Y.;Xu, B.;Deng, X.;Alfáro, J.E.;Chen, L.;Napier, D.;Lu, M.;Huang, J.A.;Liu, C.;Thibault, O.;Segal, R.;Zhou, B.P.;Kyprianou, N.;Horbinski, C.;Yang, X.H. "CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion." Oncotarget 6, 30 (2015): 29675-93. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Kadish, I.;Blalock, E.M.;Thibault, O.;Porter, N.M.;Landfield, P.W. "Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 30 (2015): 10878-87. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Porter, N.M.;Norris, C.M.;Thibault, O.;Landfield, P.W. "FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?" European journal of pharmacology 739, (2014): 74-82. [PubMed Link] | [ Full text ]
  • Latimer, C.S.;Brewer, L.D.;Searcy, J.L.;Chen, K.C.;Popović, J.;Kraner, S.D.;Thibault, O.;Blalock, E.M.;Landfield, P.W.;Porter, N.M. "Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats." Proceedings of the National Academy of Sciences of the United States of America 111, 41 (2014): E4359-66. [PubMed Link] | [ Full text ]
  • Buechel, H.M.;Popovic, J.;Staggs, K.;Anderson, K.L.;Thibault, O.;Blalock, E.M. "Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging." Frontiers in aging neuroscience 6, (2014): 13. [PubMed Link] | [ Full text ]
  • Thibault, O.;Anderson, K.L.;Demoll, C.;Brewer, L.D.;Landfield, P.W.;Porter, N.M. "Hippocampal calcium dysregulation at the nexus of diabetes and brain aging." European journal of pharmacology 719, 1-3 (2013): 34-43. [PubMed Link] | [ Full text ]
  • Pancani, T.;Anderson, K.L.;Brewer, L.D.;Kadish, I.;Demoll, C.;Landfield, P.W.;Blalock, E.M.;Porter, N.M.;Thibault, O. "Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats." Neurobiology of aging 34, 8 (2013): 1977-87. [PubMed Link] | [ Full text ]
  • Thibault, O.;Pancani, T.;Landfield, P.W.;Norris, C.M. "Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease." Biochimica et biophysica acta 1822, 4 (2012): 546-9. [PubMed Link] | [ Full text ]
  • Searcy, J.L.;Phelps, J.T.;Pancani, T.;Kadish, I.;Popovic, J.;Anderson, K.L.;Beckett, T.L.;Murphy, M.P.;Chen, K.C.;Blalock, E.M.;Landfield, P.W.;Porter, N.M.;Thibault, O. "Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease." Journal of Alzheimer's disease : JAD 30, 4 (2012): 943-61. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Norris, C.M.;Kadish, I.;Thibault, O.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 5 (2011): 1693-703. [PubMed Link] | [ Full text ]
  • Pancani, T.;Anderson, K.L.;Porter, N.M.;Thibault, O. "Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: dynamic responses to depolarization and sensitivity to pioglitazone." Cell calcium 50, 6 (2011): 548-58. [PubMed Link] | [ Full text ]
  • Buechel, H.M.;Popovic, J.;Searcy, J.L.;Porter, N.M.;Thibault, O.;Blalock, E.M. "Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age." PloS one 6, 4 (2011): e18387. [PubMed Link] | [ Full text ]
  • Latimer, C.S.;Searcy, J.L.;Bridges, M.T.;Brewer, L.D.;Popović, J.;Blalock, E.M.;Landfield, P.W.;Thibault, O.;Porter, N.M. "Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice." PloS one 6, 10 (2011): e26812. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Chen, K.C.;Porter, N.M.;Thibault, O.;Kraner, S.D.;Landfield, P.W. "Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging." Neurobiology of aging 31, 2 (2010): 328-38. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Phelps, J.T.;Pancani, T.;Searcy, J.L.;Anderson, K.L.;Gant, J.C.;Popovic, J.;Avdiushko, M.G.;Cohen, D.A.;Chen, K.C.;Porter, N.M.;Thibault, O. "Effects of long-term pioglitazone treatment on peripheral and central markers of aging." PloS one 5, 4 (2010): e10405. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Grondin, R.;Chen, K.C.;Thibault, O.;Thibault, V.;Pandya, J.D.;Dowling, A.;Zhang, Z.;Sullivan, P.;Porter, N.M.;Landfield, P.W. "Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys." The Journal of neuroscience : the official journal of the Society for Neuroscience 30, 17 (2010): 6058-71. [PubMed Link] | [ Full text ]
  • Pancani, T.;Phelps, J.T.;Searcy, J.L.;Kilgore, M.W.;Chen, K.C.;Porter, N.M.;Thibault, O. "Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons." Journal of neurochemistry 109, 6 (2009): 1800-11. [PubMed Link] | [ Full text ]
  • Kadish, I.;Thibault, O.;Blalock, E.M.;Chen, K.C.;Gant, J.C.;Porter, N.M.;Landfield, P.W. "Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 6 (2009): 1805-16. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Thibault, O. "Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization." Neurobiology of aging 30, 12 (2009): 2053-64. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Thibault, O.;Blalock, E.M.;Yang, J.;Bachstetter, A.;Kotick, J.;Schauwecker, P.E.;Hauser, K.F.;Smith, G.M.;Mervis, R.;Li, Y.;Barnes, G.N. "Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy." Epilepsia 50, 4 (2009): 629-45. [PubMed Link] | [ Full text ]
  • Rowe, W.B.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Wang, D.;Barrett, J.E.;Thibault, O.;Porter, N.M.;Rose, G.M.;Landfield, P.W. "Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 12 (2007): 3098-110. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Thibault, O.;Staton, J.;Thibault, V.;Rogers, J.T.;Garcia-Ramos, G.;Kraner, S.;Landfield, P.W.;Porter, N.M. "Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels." Brain research 1151, (2007): 20-31. [PubMed Link] | [ Full text ]
  • Thibault, O.;Gant, J.C.;Landfield, P.W. "Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store." Aging cell 6, 3 (2007): 307-17. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Porter, N.M.;Kerr, D.S.;Landfield, P.W.;Thibault, O. "Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging." Cell calcium 40, 3 (2006): 277-86. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Thibault, O.;Brewer, L.D.;Clodfelter, G.V.;Porter, N.M.;Landfield, P.W. "Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release." Journal of neurophysiology 96, 5 (2006): 2488-500. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Sama, M.M.;Landfield, P.W.;Thibault, O. "Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release." The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 13 (2006): 3482-90. [PubMed Link] | [ Full text ]
  • Kelly, K.M.;Nadon, N.L.;Morrison, J.H.;Thibault, O.;Barnes, C.A.;Blalock, E.M. "The neurobiology of aging." Epilepsy research 68 Suppl 1, (2006): S5-20. [PubMed Link] | [ Full text ]
  • Clodfelter, G.V.;Porter, N.M.;Landfield, P.W.;Thibault, O. "Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons." European journal of pharmacology 447, 2-3 (2002): 189-200. [PubMed Link] | [ Full text ]
  • Verkhratsky, A.;Landfield, P.W.;Thibault, O. "Preface. Ca2+ and neuronal pathology." European journal of pharmacology 447, 2-3 (2002): 115-7. [PubMed Link] | [ Full text ]
  • Attucci, S.;Clodfelter, G.V.;Thibault, O.;Staton, J.;Moroni, F.;Landfield, P.W.;Porter, N.M. "Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity." Neuroscience 112, 1 (2002): 183-94. [PubMed Link] | [ Full text ]
  • Thibault, O.;Hadley, R.;Landfield, P.W. "Elevated postsynaptic Ca2+ i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity." The Journal of neuroscience : the official journal of the Society for Neuroscience 21, 24 (2001): 9744-56. [PubMed Link] | [ Full text ]
  • Chen, K.C.;Blalock, E.M.;Thibault, O.;Kaminker, P.;Landfield, P.W. "Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices." Proceedings of the National Academy of Sciences of the United States of America 97, 8 (2000): 4357-62. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Thibault, O.;Thibault, V.;Chen, K.C.;Landfield, P.W. "Calcium channel density and hippocampal cell death with age in long-term culture." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 14 (1997): 5629-39. [PubMed Link] | [ Full text ]
  • Campbell, L.W.;Hao, S.Y.;Thibault, O.;Blalock, E.M.;Landfield, P.W. "Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 16, 19 (1996): 6286-95. [PubMed Link] | [ Full text ]
  • Thibault, O.;Landfield, P.W. "Increase in single L-type calcium channels in hippocampal neurons during aging." Science (New York, N.Y.) 272, 5264 (1996): 1017-20. [PubMed Link] | [ Full text ]
  • Thibault, O.;Mazzanti, M.L.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons." Journal of neuroscience methods 59, 1 (1995): 77-83. [PubMed Link] | [ Full text ]
  • Thibault, O.;Porter, N.M.;Landfield, P.W. "Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications." Proceedings of the National Academy of Sciences of the United States of America 90, 24 (1993): 11792-6. [PubMed Link] | [ Full text ]
  • Kerr, D.S.;Campbell, L.W.;Thibault, O.;Landfield, P.W. "Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging." Proceedings of the National Academy of Sciences of the United States of America 89, 18 (1992): 8527-31. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Thibault, O.;Mazzanti, M.L.;Porter, N.M.;Kerr, D.S. "Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis." Journal of neurobiology 23, 9 (1992): 1247-60. [PubMed Link] |
  • Thibault, O.;Joly, M.;Muller, D.;Schottler, F.;Dudek, S.;Lynch, G. "Long-lasting physiological effects of bath applied N-methyl-D-aspartate." Brain research 476, 1 (1989): 170-3. [PubMed Link] | [ Full text ]
  • Staubli, U.;Thibault, O.;DiLorenzo, M.;Lynch, G. "Antagonism of NMDA receptors impairs acquisition but not retention of olfactory memory." Behavioral neuroscience 103, 1 (1989): 54-60. [PubMed Link] | [ Full text ]
  • Staubli, U.;Larson, J.;Thibault, O.;Baudry, M.;Lynch, G. "Chronic administration of a thiol-proteinase inhibitor blocks long-term potentiation of synaptic responses." Brain research 444, 1 (1988): 153-8. [PubMed Link] | [ Full text ]