Nancy R. Webb, Ph.D.

Bio / Education: 

University of Virginia, Charlottesville, VA

B.A.

1981

Biology

University of Kentucky, Lexington, KY

Ph.D.

1999

Molecular Biology

 

     
Research Description: 

Research in the Webb laboratory focuses on mechanisms of cardiovascular disease, including atherosclerosis and abdominal aortic aneurysms. It has been recognized for decades that high levels of HDL in the blood reduce an individual's risk for heart attack and stroke, yet it is not well understood why HDL (the "good cholesterol") is cardioprotective. The Webb laboratory studies what regulates HDL levels in the blood, how HDL functions to reduce cardiovascular risk, and how inflammation, obesity, and diabetes alter the ability of HDL to function. Research projects integrate biochemical, cellular, and physiological analyses of HDLs obtained from transgenic mouse models as well as human subjects. Another area of research in the Webb laboratory focuses on a family of lipolytic enzymes, the secretory phospholipase A2’s (sPLA2), and their role in physiological and pathophysiological processes. The underlying hypothesis of the studies is that lipid products generated by sPLA2’s serve as bioactive mediators that have pleiotropic effects on fat, vascular, and immune cells.

Selected Publications: 

1. Webb, N.R., Connell, P.M., Graf, G.A., Smart, E.J., de Williers, W.J.S., de Beer, F.C., and van der Westhuyzen, D.R. (1998) SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. J. Biol. Chem. 273:15241-15248.
2. Webb, N.R., Cai, L., Ziemba, K.S., Yu, J., Kindy, M.S., van der Westhuyzen, D.R., and de Beer, F.C. (2002) The fate of HDL particles in vivo after SR-BI mediated selective lipid uptake. J. Lipid Res. 43: 1890-1898.
3. Boyanovsky, B.B., van der Westhuyzen, D.R., Webb, N.R. (2005) Group V sPLA2-modified LDL promotes foam cell formation by a SR-A and CD36 independent process that involves cellular proteoglycans. J. Biol. Chem. 280:32746-52.
4. Bostrom, M.A., Boyanovsky, B.B., Jordan, C.T., Wadsworth, M.P., Taatjes, D.J., de Beer, F.C., and Webb, N.R. (2007) Group V secretory phospholipase A2 promotes atherosclerosis: Evidence from genetically altered mice. Arterioscler. Thromb. Vasc. Biol. 27:600-6.
5. Li, X., Shridas, P., Forrest, K., Baily, W., and Webb, N.R. (2010) Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models. FASEB J. 24:4313-24. PMCID: PMC2974424
6. Boyanovsky, B. B., Bailey, W., Dixon, L., Shridas, P., and Webb, N.R. (2012) Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice. Am. J. Pathol. 181:1088-98. PMCID: PMC3432434
7. De Beer, M.C., Wroblewski, J.M., Noffsinger, V.P., Rateri, D.L., Howatt, D.A., Balakrishnan, A., Ji, A., Shridas, P., Thompson, J., van der Westhuyzen, D.R., Tannock, L.R., Daugherty, A., Webb, N.R, de Beer F.C. (2014) Deficiency of endogenous acute phase serum amyloid A does not impact atherosclerotic lesions in apoE-/- mice. Arterioscler. Thromb. Vasc. Biol. 34: 255-261. PMCID: PMC3951741

PubMed Publications: 

  • De Beer, M.C.;Wroblewski, J.M.;Noffsinger, V.P.;Rateri, D.L.;Howatt, D.A.;Balakrishnan, A.;Ji, A.;Shridas, P.;Thompson, J.C.;Westhuyzen, D.R.;Tannock, L.R.;Daugherty, A.;Webb, N.R.;Beer, F.C. "Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice." Arteriosclerosis, thrombosis, and vascular biology 34, 2 (2014): 255-61. [PubMed Link] | [ Full text ]
  • Rosenson, R.S.;Brewer HB, J.;Ansell, B.;Barter, P.;Chapman, M.J.;Heinecke, J.W.;Kontush, A.;Tall, A.R.;Webb, N.R. "Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges." Circulation 128, 11 (2013): 1256-67. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Wroblewski, J.M.;Noffsinger, V.P.;Ji, A.;Meyer, J.M.;Westhuyzen, D.R.;Beer, F.C.;Webb, N.R. "The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A." Journal of lipids 2013, (2013): 283486. [PubMed Link] | [ Full text ]
  • Kim, M.H.;De Beer, M.C.;Wroblewski, J.M.;Webb, N.R.;Beer, F.C. "SAA does not induce cytokine production in physiological conditions." Cytokine 61, 2 (2013): 506-12. [PubMed Link] | [ Full text ]
  • Boyanovsky, B.B.;Bailey, W.;Dixon, L.;Shridas, P.;Webb, N.R. "Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice." The American journal of pathology 181, 3 (2012): 1088-98. [PubMed Link] | [ Full text ]
  • Wroblewski, J.M.;Jahangiri, A.;Ji, A.;Beer, F.C.;Westhuyzen, D.R.;Webb, N.R. "Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase." Journal of lipid research 52, 12 (2011): 2255-61. [PubMed Link] | [ Full text ]
  • Shridas, P.;Bailey, W.M.;Talbott, K.R.;Oslund, R.C.;Gelb, M.H.;Webb, N.R. "Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages." Journal of immunology (Baltimore, Md. : 1950) 187, 1 (2011): 482-9. [PubMed Link] | [ Full text ]
  • Ji, A.;Meyer, J.M.;Cai, L.;Akinmusire, A.;De Beer, M.C.;Webb, N.R.;Westhuyzen, D.R. "Scavenger receptor SR-BI in macrophage lipid metabolism." Atherosclerosis 217, 1 (2011): 106-12. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Ji, A.;Jahangiri, A.;Vaughan, A.M.;Beer, F.C.;Westhuyzen, D.R.;Webb, N.R. "ATP binding cassette G1-dependent cholesterol efflux during inflammation." Journal of lipid research 52, 2 (2011): 345-53. [PubMed Link] | [ Full text ]
  • Zack, M.;Boyanovsky, B.B.;Shridas, P.;Bailey, W.;Forrest, K.;Howatt, D.A.;Gelb, M.H.;Beer, F.C.;Daugherty, A.;Webb, N.R. "Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice." Atherosclerosis 214, 1 (2011): 58-64. [PubMed Link] | [ Full text ]
  • Shridas, P.;Bailey, W.M.;Gizard, F.;Oslund, R.C.;Gelb, M.H.;Bruemmer, D.;Webb, N.R. "Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages." Arteriosclerosis, thrombosis, and vascular biology 30, 10 (2010): 2014-21. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Webb, N.R.;Wroblewski, J.M.;Noffsinger, V.P.;Rateri, D.L.;Ji, A.;Westhuyzen, D.R.;Beer, F.C. "Impact of serum amyloid A on high density lipoprotein composition and levels." Journal of lipid research 51, 11 (2010): 3117-25. [PubMed Link] | [ Full text ]
  • Li, X.;Shridas, P.;Forrest, K.;Bailey, W.;Webb, N.R. "Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 11 (2010): 4313-24. [PubMed Link] | [ Full text ]
  • Shridas, P.;Bailey, W.M.;Boyanovsky, B.B.;Oslund, R.C.;Gelb, M.H.;Webb, N.R. "Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands." The Journal of biological chemistry 285, 26 (2010): 20031-9. [PubMed Link] | [ Full text ]
  • Boyanovsky, B.B.;Li, X.;Shridas, P.;Sunkara, M.;Morris, A.J.;Webb, N.R. "Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines." Cytokine 50, 1 (2010): 50-7. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Webb, N.R.;Whitaker, N.L.;Wroblewski, J.M.;Jahangiri, A.;Westhuyzen, D.R.;Beer, F.C. "SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL." Arteriosclerosis, thrombosis, and vascular biology 29, 9 (2009): 1298-303. [PubMed Link] | [ Full text ]
  • Boyanovsky, B.;Zack, M.;Forrest, K.;Webb, N.R. "The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo." Arteriosclerosis, thrombosis, and vascular biology 29, 4 (2009): 532-8. [PubMed Link] | [ Full text ]
  • Boyanovsky, B.B.;Shridas, P.;Simons, M.;Westhuyzen, D.R.;Webb, N.R. "Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL." Journal of lipid research 50, 4 (2009): 641-50. [PubMed Link] | [ Full text ]
  • Jahangiri, A.;De Beer, M.C.;Noffsinger, V.;Tannock, L.R.;Ramaiah, C.;Webb, N.R.;Westhuyzen, D.R.;Beer, F.C. "HDL remodeling during the acute phase response." Arteriosclerosis, thrombosis, and vascular biology 29, 2 (2009): 261-7. [PubMed Link] | [ Full text ]
  • Boyanovsky, B.B.;Webb, N.R. "Biology of secretory phospholipase A2." Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 23, 1 (2009): 61-72. [PubMed Link] | [ Full text ]
  • Wilson, P.G.;Thompson, J.C.;Webb, N.R.;Beer, F.C.;King, V.L.;Tannock, L.R. "Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner." The American journal of pathology 173, 6 (2008): 1902-10. [PubMed Link] | [ Full text ]
  • Sun, B.;Boyanovsky, B.B.;Connelly, M.A.;Shridas, P.;Westhuyzen, D.R.;Webb, N.R. "Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI." Journal of lipid research 48, 12 (2007): 2560-70. [PubMed Link] | [ Full text ]
  • Westhuyzen, D.R.;Beer, F.C.;Webb, N.R. "HDL cholesterol transport during inflammation." Current opinion in lipidology 18, 2 (2007): 147-51. [PubMed Link] | [ Full text ]
  • Bostrom, M.A.;Boyanovsky, B.B.;Jordan, C.T.;Wadsworth, M.P.;Taatjes, D.J.;Beer, F.C.;Webb, N.R. "Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice." Arteriosclerosis, thrombosis, and vascular biology 27, 3 (2007): 600-6. [PubMed Link] | [ Full text ]
  • Sun, B.;Eckhardt, E.R.;Shetty, S.;Westhuyzen, D.R.;Webb, N.R. "Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts." Journal of lipid research 47, 8 (2006): 1700-13. [PubMed Link] | [ Full text ]
  • Eckhardt, E.R.;Cai, L.;Shetty, S.;Zhao, Z.;Szanto, A.;Webb, N.R.;Westhuyzen, D.R. "High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif." The Journal of biological chemistry 281, 7 (2006): 4348-53. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Westhuyzen, D.R.;Whitaker, N.L.;Webb, N.R.;Beer, F.C. "SR-BI-mediated selective lipid uptake segregates apoA-I and apoA-II catabolism." Journal of lipid research 46, 10 (2005): 2143-50. [PubMed Link] | [ Full text ]
  • Boyanovsky, B.B.;Westhuyzen, D.R.;Webb, N.R. "Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans." The Journal of biological chemistry 280, 38 (2005): 32746-52. [PubMed Link] | [ Full text ]
  • Daugherty, A.;Webb, N.R.;Rateri, D.L.;King, V.L. "Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis." Journal of lipid research 46, 9 (2005): 1812-22. [PubMed Link] | [ Full text ]
  • Webb, N.R. "Secretory phospholipase A2 enzymes in atherogenesis." Current opinion in lipidology 16, 3 (2005): 341-4. [PubMed Link] | [ Full text ]
  • Webb, N.R.;De Beer, M.C.;Asztalos, B.F.;Whitaker, N.;Westhuyzen, D.R.;Beer, F.C. "Remodeling of HDL remnants generated by scavenger receptor class B type I." Journal of lipid research 45, 9 (2004): 1666-73. [PubMed Link] | [ Full text ]
  • Wooton-Kee, C.R.;Boyanovsky, B.B.;Nasser, M.S.;Villiers, W.J.;Webb, N.R. "Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation." Arteriosclerosis, thrombosis, and vascular biology 24, 4 (2004): 762-7. [PubMed Link] | [ Full text ]
  • Eckhardt, E.R.;Cai, L.;Sun, B.;Webb, N.R.;Westhuyzen, D.R. "High density lipoprotein uptake by scavenger receptor SR-BII." The Journal of biological chemistry 279, 14 (2004): 14372-81. [PubMed Link] | [ Full text ]
  • Webb, N.R.;De Beer, M.C.;Beer, F.C.;Westhuyzen, D.R. "ApoB-containing lipoproteins in apoE-deficient mice are not metabolized by the class B scavenger receptor BI." Journal of lipid research 45, 2 (2004): 272-80. [PubMed Link] | [ Full text ]
  • Webb, N.R.;Bostrom, M.A.;Szilvassy, S.J.;Westhuyzen, D.R.;Daugherty, A.;Beer, F.C. "Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice." Arteriosclerosis, thrombosis, and vascular biology 23, 2 (2003): 263-8. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Zhao, Z.;Webb, N.R.;Westhuyzen, D.R.;Villiers, W.J. "Lack of a direct role for macrosialin in oxidized LDL metabolism." Journal of lipid research 44, 4 (2003): 674-85. [PubMed Link] | [ Full text ]
  • Webb, N.R.;Cai, L.;Ziemba, K.S.;Yu, J.;Kindy, M.S.;Westhuyzen, D.R.;Beer, F.C. "The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake." Journal of lipid research 43, 11 (2002): 1890-8. [PubMed Link] | [ Full text ]
  • Webb, N.R.;De Beer, M.C.;Yu, J.;Kindy, M.S.;Daugherty, A.;Westhuyzen, D.R.;Beer, F.C. "Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice." Journal of lipid research 43, 9 (2002): 1421-8. [PubMed Link] | [ Full text ]
  • Villiers, W.J.;Cai, L.;Webb, N.R.;De Beer, M.C.;Westhuyzen, D.R.;Beer, F.C. "CD36 does not play a direct role in HDL or LDL metabolism." Journal of lipid research 42, 8 (2001): 1231-8. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Durbin, D.M.;Cai, L.;Mirocha, N.;Jonas, A.;Webb, N.R.;Beer, F.C.;Westhuyzen, D.R. "Apolipoprotein A-II modulates the binding and selective lipid uptake of reconstituted high density lipoprotein by scavenger receptor BI." The Journal of biological chemistry 276, 19 (2001): 15832-9. [PubMed Link] | [ Full text ]
  • Beer, F.C.;Connell, P.M.;Yu, J.;De Beer, M.C.;Webb, N.R.;Westhuyzen, D.R. "HDL modification by secretory phospholipase A(2) promotes scavenger receptor class B type I interaction and accelerates HDL catabolism." Journal of lipid research 41, 11 (2000): 1849-57. [PubMed Link] | [ Full text ]
  • Hogstrand, C.;Ferguson, E.A.;Galvez, F.;Shaw, J.R.;Webb, N.A.;Wood, C.M. "Physiology of acute silver toxicity in the starry flounder (Platichthys stellatus) in seawater." Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 169, 7 (1999): 461-73. [PubMed Link] |
  • Webb, N.R.;Connell, P.M.;Graf, G.A.;Smart, E.J.;Villiers, W.J.;Beer, F.C.;Westhuyzen, D.R. "SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells." The Journal of biological chemistry 273, 24 (1998): 15241-8. [PubMed Link] | [ Full text ]
  • Hogstrand, C.;Webb, N.;Wood, C.M. "Covariation in regulation of affinity for branchial zinc and calcium uptake in freshwater rainbow trout." The Journal of experimental biology 201, Pt 11 (1998): 1809-15. [PubMed Link] | [ Full text ]
  • Webb, N.R.;De Beer, M.C.;Westhuyzen, D.R.;Kindy, M.S.;Banka, C.L.;Tsukamoto, K.;Rader, D.L.;Beer, F.C. "Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice." Journal of lipid research 38, 8 (1997): 1583-90. [PubMed Link] | [ Full text ]
  • Webb, N.R.;Villiers, W.J.;Connell, P.M.;Beer, F.C.;Westhuyzen, D.R. "Alternative forms of the scavenger receptor BI (SR-BI)." Journal of lipid research 38, 7 (1997): 1490-5. [PubMed Link] | [ Full text ]
  • De Beer, M.C.;Beer, F.C.;Gerardot, C.J.;Cecil, D.R.;Webb, N.R.;Goodson, M.L.;Kindy, M.S. "Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family." Genomics 34, 1 (1996): 139-42. [PubMed Link] | [ Full text ]
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