Nada M Porter, Ph.D.

Bio / Education: 

1987 University of Illinois, Chicago, PhD in Pharmacology
1987-1991 University of Michigan, Ann Arbor, Post-Doctoral fellow, Neurology
1991 - 1996 Research Assistant Professor, Department of Pharmacology, University of Kentucky
1996 - 2002 Assistant Professor, Department of Pharmacology, University of Kentucky
2002 - Present Associate Professor, Department of Molecular and Biomedical Pharmacology, University of Kentucky

Research Description: 

Research interests are in the area of hormone modulation of ion channels. Specifically, our studies address two central questions:

1) Do stress hormones adversely affect neuronal viability by altering calcium channel influx?

2) Under what conditions can steroid hormones have a beneficial or adverse effect?

Recent studies indicate that steroid hormones regulate calcium channel activity. Current efforts are focused on how these changes in calcium influx affect neuronal viability. Answers to these questions will help determine whether neuronal calcium channels are potential therapeutic targets for degenerative or traumatic disorders of the brain.

PubMed Publications: 

  • Frazier, H.N.;Maimaiti, S.;Anderson, K.L.;Brewer, L.D.;Gant, J.C.;Porter, N.M.;Thibault, O. "Calcium's role as nuanced modulator of cellular physiology in the brain." Biochemical and biophysical research communications 483, 4 (2017): 981-987. [PubMed Link] | [ Full text ]
  • Anderson, K.L.;Frazier, H.N.;Maimaiti, S.;Bakshi, V.V.;Majeed, Z.R.;Brewer, L.D.;Porter, N.M.;Lin, A.L.;Thibault, O. "Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism." The journals of gerontology. Series A, Biological sciences and medical sciences 72, 2 (2017): 189-197. [PubMed Link] | [ Full text ]
  • Maimaiti, S.;Anderson, K.L.;Demoll, C.;Brewer, L.D.;Rauh, B.A.;Gant, J.C.;Blalock, E.M.;Porter, N.M.;Thibault, O. "Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging." The journals of gerontology. Series A, Biological sciences and medical sciences 71, 1 (2016): 30-9. [PubMed Link] | [ Full text ]
  • Maimaiti, S.;Demoll, C.;Anderson, K.L.;Griggs, R.B.;Taylor, B.K.;Porter, N.M.;Thibault, O. "Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging." Brain research 1621, (2015): 214-21. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Kadish, I.;Blalock, E.M.;Thibault, O.;Porter, N.M.;Landfield, P.W. "Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 30 (2015): 10878-87. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Porter, N.M.;Norris, C.M.;Thibault, O.;Landfield, P.W. "FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?" European journal of pharmacology 739, (2014): 74-82. [PubMed Link] | [ Full text ]
  • Latimer, C.S.;Brewer, L.D.;Searcy, J.L.;Chen, K.C.;Popović, J.;Kraner, S.D.;Thibault, O.;Blalock, E.M.;Landfield, P.W.;Porter, N.M. "Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats." Proceedings of the National Academy of Sciences of the United States of America 111, 41 (2014): E4359-66. [PubMed Link] | [ Full text ]
  • Niedowicz, D.M.;Reeves, V.L.;Platt, T.L.;Kohler, K.;Beckett, T.L.;Powell, D.K.;Lee, T.L.;Sexton, T.R.;Song, E.S.;Brewer, L.D.;Latimer, C.S.;Kraner, S.D.;Larson, K.L.;Ozcan, S.;Norris, C.M.;Hersh, L.B.;Porter, N.M.;Wilcock, D.M.;Murphy, M.P. "Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia." Acta neuropathologica communications 2, (2014): 64. [PubMed Link] | [ Full text ]
  • Thibault, O.;Anderson, K.L.;Demoll, C.;Brewer, L.D.;Landfield, P.W.;Porter, N.M. "Hippocampal calcium dysregulation at the nexus of diabetes and brain aging." European journal of pharmacology 719, 1-3 (2013): 34-43. [PubMed Link] | [ Full text ]
  • Keeney, J.T.;Förster, S.;Sultana, R.;Brewer, L.D.;Latimer, C.S.;Cai, J.;Klein, J.B.;Porter, N.M.;Butterfield, D.A. "Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline." Free radical biology & medicine 65, (2013): 324-34. [PubMed Link] | [ Full text ]
  • Pancani, T.;Anderson, K.L.;Brewer, L.D.;Kadish, I.;Demoll, C.;Landfield, P.W.;Blalock, E.M.;Porter, N.M.;Thibault, O. "Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats." Neurobiology of aging 34, 8 (2013): 1977-87. [PubMed Link] | [ Full text ]
  • Chen, K.C.;Blalock, E.M.;Curran-Rauhut, M.A.;Kadish, I.;Blalock, S.J.;Brewer, L.;Porter, N.M.;Landfield, P.W. "Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging." Endocrinology 154, 8 (2013): 2807-20. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Bohannon, J.H.;Curran-Rauhut, M.;Buechel, H.M.;Dowling, A.L.;Brewer, L.D.;Popovic, J.;Thibault, V.;Kraner, S.D.;Chen, K.C.;Blalock, E.M. "Hippocampal CA1 transcriptional profile of sleep deprivation: relation to aging and stress." PloS one 7, 7 (2012): e40128. [PubMed Link] | [ Full text ]
  • Searcy, J.L.;Phelps, J.T.;Pancani, T.;Kadish, I.;Popovic, J.;Anderson, K.L.;Beckett, T.L.;Murphy, M.P.;Chen, K.C.;Blalock, E.M.;Landfield, P.W.;Porter, N.M.;Thibault, O. "Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease." Journal of Alzheimer's disease : JAD 30, 4 (2012): 943-61. [PubMed Link] | [ Full text ]
  • Ghobrial, I.M.;Munshi, N.C.;Harris, B.N.;Shi, P.;Porter, N.M.;Schlossman, R.L.;Laubach, J.P.;Anderson, K.C.;Desaiah, D.;Myrand, S.P.;Wooldridge, J.E.;Richardson, P.G.;Abonour, R. "A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma." American journal of hematology 86, 7 (2011): 573-8. [PubMed Link] |
  • Gant, J.C.;Chen, K.C.;Norris, C.M.;Kadish, I.;Thibault, O.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 5 (2011): 1693-703. [PubMed Link] | [ Full text ]
  • Pancani, T.;Anderson, K.L.;Porter, N.M.;Thibault, O. "Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: dynamic responses to depolarization and sensitivity to pioglitazone." Cell calcium 50, 6 (2011): 548-58. [PubMed Link] | [ Full text ]
  • Buechel, H.M.;Popovic, J.;Searcy, J.L.;Porter, N.M.;Thibault, O.;Blalock, E.M. "Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age." PloS one 6, 4 (2011): e18387. [PubMed Link] | [ Full text ]
  • Latimer, C.S.;Searcy, J.L.;Bridges, M.T.;Brewer, L.D.;Popović, J.;Blalock, E.M.;Landfield, P.W.;Thibault, O.;Porter, N.M. "Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice." PloS one 6, 10 (2011): e26812. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Chen, K.C.;Porter, N.M.;Thibault, O.;Kraner, S.D.;Landfield, P.W. "Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging." Neurobiology of aging 31, 2 (2010): 328-38. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Phelps, J.T.;Pancani, T.;Searcy, J.L.;Anderson, K.L.;Gant, J.C.;Popovic, J.;Avdiushko, M.G.;Cohen, D.A.;Chen, K.C.;Porter, N.M.;Thibault, O. "Effects of long-term pioglitazone treatment on peripheral and central markers of aging." PloS one 5, 4 (2010): e10405. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Grondin, R.;Chen, K.C.;Thibault, O.;Thibault, V.;Pandya, J.D.;Dowling, A.;Zhang, Z.;Sullivan, P.;Porter, N.M.;Landfield, P.W. "Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys." The Journal of neuroscience : the official journal of the Society for Neuroscience 30, 17 (2010): 6058-71. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Dowling, A.L.;Curran-Rauhut, M.A.;Landfield, P.W.;Porter, N.M.;Blalock, E.M. "Estradiol reverses a calcium-related biomarker of brain aging in female rats." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 19 (2009): 6058-67. [PubMed Link] | [ Full text ]
  • Pancani, T.;Phelps, J.T.;Searcy, J.L.;Kilgore, M.W.;Chen, K.C.;Porter, N.M.;Thibault, O. "Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons." Journal of neurochemistry 109, 6 (2009): 1800-11. [PubMed Link] | [ Full text ]
  • Kadish, I.;Thibault, O.;Blalock, E.M.;Chen, K.C.;Gant, J.C.;Porter, N.M.;Landfield, P.W. "Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 6 (2009): 1805-16. [PubMed Link] | [ Full text ]
  • Rowe, W.B.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Wang, D.;Barrett, J.E.;Thibault, O.;Porter, N.M.;Rose, G.M.;Landfield, P.W. "Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats." The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 12 (2007): 3098-110. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Thibault, O.;Staton, J.;Thibault, V.;Rogers, J.T.;Garcia-Ramos, G.;Kraner, S.;Landfield, P.W.;Porter, N.M. "Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels." Brain research 1151, (2007): 20-31. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Blalock, E.M.;Chen, K.C.;Porter, N.M. "A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease." Current Alzheimer research 4, 2 (2007): 205-12. [PubMed Link] |
  • Brewer, L.D.;Porter, N.M.;Kerr, D.S.;Landfield, P.W.;Thibault, O. "Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging." Cell calcium 40, 3 (2006): 277-86. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Thibault, O.;Brewer, L.D.;Clodfelter, G.V.;Porter, N.M.;Landfield, P.W. "Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release." Journal of neurophysiology 96, 5 (2006): 2488-500. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Stromberg, A.J.;Norris, C.M.;Kadish, I.;Kraner, S.D.;Porter, N.M.;Landfield, P.W. "Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation." Ageing research reviews 4, 4 (2005): 481-512. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Kadish, I.;Blalock, E.M.;Chen, K.C.;Thibault, V.;Porter, N.M.;Landfield, P.W.;Kraner, S.D. "Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models." The Journal of neuroscience : the official journal of the Society for Neuroscience 25, 18 (2005): 4649-58. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Geddes, J.W.;Chen, K.C.;Porter, N.M.;Markesbery, W.R.;Landfield, P.W. "Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses." Proceedings of the National Academy of Sciences of the United States of America 101, 7 (2004): 2173-8. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Sharrow, K.;Herman, J.P.;Porter, N.M.;Foster, T.C.;Landfield, P.W. "Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 23, 9 (2003): 3807-19. [PubMed Link] | [ Full text ]
  • Clodfelter, G.V.;Porter, N.M.;Landfield, P.W.;Thibault, O. "Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons." European journal of pharmacology 447, 2-3 (2002): 189-200. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Chen, K.C.;Porter, N.M.;Landfield, P.W. "Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture." Neuroscience 110, 2 (2002): 213-25. [PubMed Link] | [ Full text ]
  • Attucci, S.;Clodfelter, G.V.;Thibault, O.;Staton, J.;Moroni, F.;Landfield, P.W.;Porter, N.M. "Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity." Neuroscience 112, 1 (2002): 183-94. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Thibault, V.;Chen, K.C.;Langub, M.C.;Landfield, P.W.;Porter, N.M. "Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 21, 1 (2001): 98-108. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures." The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 19 (1999): 8674-84. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Landfield, P.W. "Stress hormones and brain aging: adding injury to insult?" Nature neuroscience 1, 1 (1998): 3-4. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Thibault, O.;Thibault, V.;Chen, K.C.;Landfield, P.W. "Calcium channel density and hippocampal cell death with age in long-term culture." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 14 (1997): 5629-39. [PubMed Link] | [ Full text ]
  • Thibault, O.;Mazzanti, M.L.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons." Journal of neuroscience methods 59, 1 (1995): 77-83. [PubMed Link] | [ Full text ]
  • Thibault, O.;Porter, N.M.;Landfield, P.W. "Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications." Proceedings of the National Academy of Sciences of the United States of America 90, 24 (1993): 11792-6. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Angelotti, T.P.;Twyman, R.E.;Macdonald, R.L. "Kinetic properties of alpha 1 beta 1 gamma-aminobutyric acidA receptor channels expressed in Chinese hamster ovary cells: regulation by pentobarbital and picrotoxin." Molecular pharmacology 42, 5 (1992): 872-81. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Thibault, O.;Mazzanti, M.L.;Porter, N.M.;Kerr, D.S. "Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis." Journal of neurobiology 23, 9 (1992): 1247-60. [PubMed Link] |
  • Moss, S.J.;Smart, T.G.;Porter, N.M.;Nayeem, N.;Devine, J.;Stephenson, F.A.;Macdonald, R.L.;Barnard, E.A. "Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties." European journal of pharmacology 189, 1 (1990): 77-88. [PubMed Link] |
  • Porter, N.M.;Twyman, R.E.;Uhler, M.D.;Macdonald, R.L. "Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons." Neuron 5, 6 (1990): 789-96. [PubMed Link] | [ Full text ]
  • Hawkins, M.;Dugich, M.M.;Porter, N.M.;Urbancic, M.;Radulovacki, M. "Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain." Brain research bulletin 21, 3 (1988): 479-82. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Radulovacki, M.;Green, R.D. "Desensitization of adenosine and dopamine receptors in rat brain after treatment with adenosine analogs." The Journal of pharmacology and experimental therapeutics 244, 1 (1988): 218-25. [PubMed Link] | [ Full text ]