Mark E Kleinman, M.D.

Bio / Education: 

Fellowship

Vitreoretinal Surgery, University of Kentucky, Lexington, KY

Certifications or Special Training

American Board of Ophthalmology

PubMed Publications: 

  • Ouseph, M.M.;Kleinman, M.E.;Wang, Q.J. "Vision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease)." Annals of the New York Academy of Sciences 1371, 1 (2016): 55-67. [PubMed Link] | [ Full text ]
  • Berner, A.K.;Kleinman, M.E. "Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration." Advances in experimental medicine and biology 854, (2016): 39-44. [PubMed Link] | [ Full text ]
  • Gelfand, B.D.;Wright, C.B.;Kim, Y.;Yasuma, T.;Yasuma, R.;Li, S.;Fowler, B.J.;Bastos-Carvalho, A.;Kerur, N.;Uittenbogaard, A.;Shan, Y.;Lou, D.;Kleinman, M.E.;McDonald, W.H.;Núñez, G.;Georgel, P.;Dunaief, J.L.;Ambati, J. "Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome." Cell reports 11, 11 (2015): 1686-93. [PubMed Link] | [ Full text ]
  • Kleinman, M.E.;Ambati, J. "Clocking in on diabetic retinopathy." Diabetes 62, 1 (2013): 29-30. [PubMed Link] | [ Full text ]
  • Tarallo, V.;Hirano, Y.;Gelfand, B.D.;Dridi, S.;Kerur, N.;Kim, Y.;Cho, W.G.;Kaneko, H.;Fowler, B.J.;Bogdanovich, S.;Albuquerque, R.J.;Hauswirth, W.W.;Chiodo, V.A.;Kugel, J.F.;Goodrich, J.A.;Ponicsan, S.L.;Chaudhuri, G.;Murphy, M.P.;Dunaief, J.L.;Ambati, B.K.;Ogura, Y.;Yoo, J.W.;Lee, D.K.;Provost, P.;Hinton, D.R.;Núñez, G.;Baffi, J.Z.;Kleinman, M.E.;Ambati, J. "DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88." Cell 149, 4 (2012): 847-59. [PubMed Link] | [ Full text ]
  • Kleinman, M.E.;Kaneko, H.;Cho, W.G.;Dridi, S.;Fowler, B.J.;Blandford, A.D.;Albuquerque, R.J.;Hirano, Y.;Terasaki, H.;Kondo, M.;Fujita, T.;Ambati, B.K.;Tarallo, V.;Gelfand, B.D.;Bogdanovich, S.;Baffi, J.Z.;Ambati, J. "Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3." Molecular therapy : the journal of the American Society of Gene Therapy 20, 1 (2012): 101-8. [PubMed Link] | [ Full text ]
  • Dridi, S.;Hirano, Y.;Tarallo, V.;Kim, Y.;Fowler, B.J.;Ambati, B.K.;Bogdanovich, S.;Chiodo, V.A.;Hauswirth, W.W.;Kugel, J.F.;Goodrich, J.A.;Ponicsan, S.L.;Hinton, D.R.;Kleinman, M.E.;Baffi, J.Z.;Gelfand, B.D.;Ambati, J. "ERK1/2 activation is a therapeutic target in age-related macular degeneration." Proceedings of the National Academy of Sciences of the United States of America 109, 34 (2012): 13781-6. [PubMed Link] | [ Full text ]
  • Kleinman, M.E.;Ambati, J. "A window to innate neuroimmunity: Toll-like receptor-mediated cell responses in the retina." Advances in experimental medicine and biology 723, (2012): 3-9. [PubMed Link] | [ Full text ]
  • Kaneko, H.;Dridi, S.;Tarallo, V.;Gelfand, B.D.;Fowler, B.J.;Cho, W.G.;Kleinman, M.E.;Ponicsan, S.L.;Hauswirth, W.W.;Chiodo, V.A.;Karikó, K.;Yoo, J.W.;Lee, D.K.;Hadziahmetovic, M.;Song, Y.;Misra, S.;Chaudhuri, G.;Buaas, F.W.;Braun, R.E.;Hinton, D.R.;Zhang, Q.;Grossniklaus, H.E.;Provis, J.M.;Madigan, M.C.;Milam, A.H.;Justice, N.L.;Albuquerque, R.J.;Blandford, A.D.;Bogdanovich, S.;Hirano, Y.;Witta, J.;Fuchs, E.;Littman, D.R.;Ambati, B.K.;Rudin, C.M.;Chong, M.M.;Provost, P.;Kugel, J.F.;Goodrich, J.A.;Dunaief, J.L.;Baffi, J.Z.;Ambati, J. "DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration." Nature 471, 7338 (2011): 325-30. [PubMed Link] | [ Full text ]
  • Kleinman, M.E.;Baffi, J.Z.;Ambati, J. "The multifactorial nature of retinal vascular disease." Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 224 Suppl 1, (2010): 16-24. [PubMed Link] | [ Full text ]
  • Albuquerque, R.J.;Hayashi, T.;Cho, W.G.;Kleinman, M.E.;Dridi, S.;Takeda, A.;Baffi, J.Z.;Yamada, K.;Kaneko, H.;Green, M.G.;Chappell, J.;Wilting, J.;Weich, H.A.;Yamagami, S.;Amano, S.;Mizuki, N.;Alexander, J.S.;Peterson, M.L.;Brekken, R.A.;Hirashima, M.;Capoor, S.;Usui, T.;Ambati, B.K.;Ambati, J. "Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth." Nature medicine 15, 9 (2009): 1023-30. [PubMed Link] | [ Full text ]
  • Takeda, A.;Baffi, J.Z.;Kleinman, M.E.;Cho, W.G.;Nozaki, M.;Yamada, K.;Kaneko, H.;Albuquerque, R.J.;Dridi, S.;Saito, K.;Raisler, B.J.;Budd, S.J.;Geisen, P.;Munitz, A.;Ambati, B.K.;Green, M.G.;Ishibashi, T.;Wright, J.D.;Humbles, A.A.;Gerard, C.J.;Ogura, Y.;Pan, Y.;Smith, J.R.;Grisanti, S.;Hartnett, M.E.;Rothenberg, M.E.;Ambati, J. "CCR3 is a target for age-related macular degeneration diagnosis and therapy." Nature 460, 7252 (2009): 225-30. [PubMed Link] | [ Full text ]
  • Cho, W.G.;Albuquerque, R.J.;Kleinman, M.E.;Tarallo, V.;Greco, A.;Nozaki, M.;Green, M.G.;Baffi, J.Z.;Ambati, B.K.;De Falco, M.;Alexander, J.S.;Brunetti, A.;De Falco, S.;Ambati, J. "Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth." Proceedings of the National Academy of Sciences of the United States of America 106, 17 (2009): 7137-42. [PubMed Link] | [ Full text ]
  • Kleinman, M.E.;Ambati, J. "Fifty years later: the disk goes to the prom." The Journal of clinical investigation 118, 8 (2008): 2681-4. [PubMed Link] | [ Full text ]
  • Kleinman, M.E.;Yamada, K.;Takeda, A.;Chandrasekaran, V.;Nozaki, M.;Baffi, J.Z.;Albuquerque, R.J.;Yamasaki, S.;Itaya, M.;Pan, Y.;Appukuttan, B.;Gibbs, D.;Yang, Z.;Karikó, K.;Ambati, B.K.;Wilgus, T.A.;DiPietro, L.A.;Sakurai, E.;Zhang, K.;Smith, J.R.;Taylor, E.W.;Ambati, J. "Sequence- and target-independent angiogenesis suppression by siRNA via TLR3." Nature 452, 7187 (2008): 591-7. [PubMed Link] | [ Full text ]