Kuey Chu Chen, Ph.D.

Bio / Education: 

Ph.D. in Genetics. University of California, Davis, 1983.

Research Description: 

Research activities involve studies of gene expression in brain in relation to aging and hormone regulation. Research approaches emphasize the use of molecular biology, particularly quantitative analysis of messenger RNA in the brain, to investigate the expression of certain genes, including hormone receptors, calcium channels and various second messengers. Techniques of quantitative real-time PCR and DNA microarray analyses are routinely being used in the lab. Several new cutting edge approaches including using epigenetic nCounter RNA measurement, genome-wide RNA sequencing, epigenetic marks analyses and laser capture tissue microdissection are being established.

PubMed Publications: 

  • Riedmann, C.;Ma, Y.;Melikishvili, M.;Godfrey, S.G.;Zhang, Z.;Chen, K.C.;Rouchka, E.C.;Fondufe-Mittendorf, Y.N. "Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns." BMC genomics 16, (2015): 212. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Kadish, I.;Blalock, E.M.;Thibault, O.;Porter, N.M.;Landfield, P.W. "Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 30 (2015): 10878-87. [PubMed Link] | [ Full text ]
  • Gonzalez, O.A.;Novak, M.J.;Kirakodu, S.;Stromberg, A.;Nagarajan, R.;Huang, C.B.;Chen, K.C.;Orraca, L.;Martinez-Gonzalez, J.;Ebersole, J.L. "Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues." Immunological investigations 44, 7 (2015): 643-64. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Porter, N.M.;Norris, C.M.;Thibault, O.;Landfield, P.W. "FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?" European journal of pharmacology 739, (2014): 74-82. [PubMed Link] | [ Full text ]
  • Latimer, C.S.;Brewer, L.D.;Searcy, J.L.;Chen, K.C.;Popović, J.;Kraner, S.D.;Thibault, O.;Blalock, E.M.;Landfield, P.W.;Porter, N.M. "Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats." Proceedings of the National Academy of Sciences of the United States of America 111, 41 (2014): E4359-66. [PubMed Link] | [ Full text ]
  • Gonzalez, O.A.;Novak, M.J.;Kirakodu, S.;Orraca, L.;Chen, K.C.;Stromberg, A.;Gonzalez-Martinez, J.;Ebersole, J.L. "Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis." Journal of clinical periodontology 41, 4 (2014): 327-39. [PubMed Link] | [ Full text ]
  • Chen, K.C.;Blalock, E.M.;Curran-Rauhut, M.A.;Kadish, I.;Blalock, S.J.;Brewer, L.;Porter, N.M.;Landfield, P.W. "Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging." Endocrinology 154, 8 (2013): 2807-20. [PubMed Link] | [ Full text ]
  • Porter, N.M.;Bohannon, J.H.;Curran-Rauhut, M.;Buechel, H.M.;Dowling, A.L.;Brewer, L.D.;Popovic, J.;Thibault, V.;Kraner, S.D.;Chen, K.C.;Blalock, E.M. "Hippocampal CA1 transcriptional profile of sleep deprivation: relation to aging and stress." PloS one 7, 7 (2012): e40128. [PubMed Link] | [ Full text ]
  • Searcy, J.L.;Phelps, J.T.;Pancani, T.;Kadish, I.;Popovic, J.;Anderson, K.L.;Beckett, T.L.;Murphy, M.P.;Chen, K.C.;Blalock, E.M.;Landfield, P.W.;Porter, N.M.;Thibault, O. "Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease." Journal of Alzheimer's disease : JAD 30, 4 (2012): 943-61. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Norris, C.M.;Kadish, I.;Thibault, O.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 5 (2011): 1693-703. [PubMed Link] | [ Full text ]
  • Go, Y.Y.;Bailey, E.;Cook, D.G.;Coleman, S.J.;Macleod, J.N.;Chen, K.C.;Timoney, P.J.;Balasuriya, U.B. "Genome-wide association study among four horse breeds identifies a common haplotype associated with in vitro CD3+ T cell susceptibility/resistance to equine arteritis virus infection." Journal of virology 85, 24 (2011): 13174-84. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Chen, K.C.;Porter, N.M.;Thibault, O.;Kraner, S.D.;Landfield, P.W. "Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging." Neurobiology of aging 31, 2 (2010): 328-38. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Phelps, J.T.;Pancani, T.;Searcy, J.L.;Anderson, K.L.;Gant, J.C.;Popovic, J.;Avdiushko, M.G.;Cohen, D.A.;Chen, K.C.;Porter, N.M.;Thibault, O. "Effects of long-term pioglitazone treatment on peripheral and central markers of aging." PloS one 5, 4 (2010): e10405. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Grondin, R.;Chen, K.C.;Thibault, O.;Thibault, V.;Pandya, J.D.;Dowling, A.;Zhang, Z.;Sullivan, P.;Porter, N.M.;Landfield, P.W. "Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys." The Journal of neuroscience : the official journal of the Society for Neuroscience 30, 17 (2010): 6058-71. [PubMed Link] | [ Full text ]
  • Pancani, T.;Phelps, J.T.;Searcy, J.L.;Kilgore, M.W.;Chen, K.C.;Porter, N.M.;Thibault, O. "Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons." Journal of neurochemistry 109, 6 (2009): 1800-11. [PubMed Link] | [ Full text ]
  • Landfield, P.W.;Blalock, E.M.;Chen, K.C.;Porter, N.M. "A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease." Current Alzheimer research 4, 2 (2007): 205-12. [PubMed Link] |
  • Turchan-Cholewo, J.;Liu, Y.;Gartner, S.;Reid, R.;Jie, C.;Peng, X.;Chen, K.C.;Chauhan, A.;Haughey, N.;Cutler, R.;Mattson, M.P.;Pardo, C.;Conant, K.;Sacktor, N.;McArthur, J.C.;Hauser, K.F.;Gairola, C.;Nath, A. "Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl." Neurobiology of disease 23, 1 (2006): 109-19. [PubMed Link] | [ Full text ]
  • Lien, Y.C.;Noel, T.;Liu, H.;Stromberg, A.J.;Chen, K.C.;St Clair, D.K. "Phospholipase C-delta1 is a critical target for tumor necrosis factor receptor-mediated protection against adriamycin-induced cardiac injury." Cancer research 66, 8 (2006): 4329-38. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Stromberg, A.J.;Norris, C.M.;Kadish, I.;Kraner, S.D.;Porter, N.M.;Landfield, P.W. "Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation." Ageing research reviews 4, 4 (2005): 481-512. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Kadish, I.;Blalock, E.M.;Chen, K.C.;Thibault, V.;Porter, N.M.;Landfield, P.W.;Kraner, S.D. "Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models." The Journal of neuroscience : the official journal of the Society for Neuroscience 25, 18 (2005): 4649-58. [PubMed Link] | [ Full text ]
  • Lee, Y.W.;Eum, S.Y.;Chen, K.C.;Hennig, B.;Toborek, M. "Gene expression profile in interleukin-4-stimulated human vascular endothelial cells." Molecular medicine (Cambridge, Mass.) 10, 1-6 (2004): 19-27. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Geddes, J.W.;Chen, K.C.;Porter, N.M.;Markesbery, W.R.;Landfield, P.W. "Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses." Proceedings of the National Academy of Sciences of the United States of America 101, 7 (2004): 2173-8. [PubMed Link] | [ Full text ]
  • Getchell, T.V.;Peng, X.;Green, C.P.;Stromberg, A.J.;Chen, K.C.;Mattson, M.P.;Getchell, M.L. "In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice." Journal of neuroscience research 77, 3 (2004): 430-52. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Sharrow, K.;Herman, J.P.;Porter, N.M.;Foster, T.C.;Landfield, P.W. "Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 23, 9 (2003): 3807-19. [PubMed Link] | [ Full text ]
  • Peng, X.;Wood, C.L.;Blalock, E.M.;Chen, K.C.;Landfield, P.W.;Stromberg, A.J. "Statistical implications of pooling RNA samples for microarray experiments." BMC bioinformatics 4, (2003): 26. [PubMed Link] | [ Full text ]
  • Getchell, T.V.;Peng, X.;Stromberg, A.J.;Chen, K.C.;Paul Green, C.;Subhedar, N.K.;Shah, D.S.;Mattson, M.P.;Getchell, M.L. "Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice." Ageing research reviews 2, 2 (2003): 211-43. [PubMed Link] | [ Full text ]
  • Norris, C.M.;Blalock, E.M.;Chen, K.C.;Porter, N.M.;Landfield, P.W. "Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture." Neuroscience 110, 2 (2002): 213-25. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Chen, K.C.;Vanaman, T.C.;Landfield, P.W.;Slevin, J.T. "Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices." Epilepsy research 43, 3 (2001): 211-26. [PubMed Link] | [ Full text ]
  • Brewer, L.D.;Thibault, V.;Chen, K.C.;Langub, M.C.;Landfield, P.W.;Porter, N.M. "Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 21, 1 (2001): 98-108. [PubMed Link] | [ Full text ]
  • Chen, K.C.;Blalock, E.M.;Thibault, O.;Kaminker, P.;Landfield, P.W. "Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices." Proceedings of the National Academy of Sciences of the United States of America 97, 8 (2000): 4357-62. [PubMed Link] | [ Full text ]
  • Herman, J.P.;Chen, K.C.;Booze, R.;Landfield, P.W. "Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats." Neurobiology of aging 19, 6 (1998): 581-7. [PubMed Link] | [ Full text ]
  • Thibault, O.;Porter, N.M.;Chen, K.C.;Blalock, E.M.;Kaminker, P.G.;Clodfelter, G.V.;Brewer, L.D.;Landfield, P.W. "Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions." Cell calcium 24, 5-6 (1998): 417-33. [PubMed Link] |
  • Porter, N.M.;Thibault, O.;Thibault, V.;Chen, K.C.;Landfield, P.W. "Calcium channel density and hippocampal cell death with age in long-term culture." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, 14 (1997): 5629-39. [PubMed Link] | [ Full text ]
  • Davidson, J.N.;Chen, K.C.;Jamison, R.S.;Musmanno, L.A.;Kern, C.B. "The evolutionary history of the first three enzymes in pyrimidine biosynthesis." BioEssays : news and reviews in molecular, cellular and developmental biology 15, 3 (1993): 157-64. [PubMed Link] | [ Full text ]
  • Davidson, J.N.;Khattar, N.H.;Chen, K.C. "An unusual Alu repeat sequence within the CAD gene." Journal of molecular evolution 32, 2 (1991): 162-6. [PubMed Link] |
  • Davidson, J.N.;Rao, G.N.;Niswander, L.;Andreano, C.;Tamer, C.;Chen, K.C. "Organization and nucleotide sequence of the 3' end of the human CAD gene." DNA and cell biology 9, 9 (1990): 667-76. [PubMed Link] | [ Full text ]
  • Chen, K.C.;Vannais, D.B.;Jones, C.;Patterson, D.;Davidson, J.N. "Mapping of the gene encoding the multifunctional protein carrying out the first three steps of pyrimidine biosynthesis to human chromosome 2." Human genetics 82, 1 (1989): 40-4. [PubMed Link] |