Jia Luo, Ph.D.

Bio / Education: 

University of Iowa College of Medicine, Ph.D., 1995

Research Description: 

Alcoholism, alcohol abuse, and the medical complications of excessive drinking are major world-wide health problems. There are three long-term goals of my laboratory: (1) Alcohol exposure during development results in fetal alcohol spectrum disorders (FASD) and induces profound damages to the central nervous system (CNS). I am interested in elucidating cellular/molecular mechanisms underlying alcohol-induced damage to the developing brain. Particularly I am interested in the interaction among oxidative stress, endoplasmic reticulum stress and autophagy and how the interaction contributes to alcohol-induced CNS damage. (2) Alcohol is a tumor promoter and enhances the progression of mammary tumor. I am interested in elucidating cellular/molecular mechanisms underlying alcohol-promoted tumor progression, particularly the metastasis of breast cancer cells. (3) Chronic and heavy alcohol abuse causes neurodegeneration and thiamine deficiency (TD). I am interested in elucidating the role of TD in CNS damages caused by chronic alcohol exposure.

PubMed Publications: 

  • Wang, Y.;Xu, M.;Ke, Z.J.;Luo, J. "Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer." Pharmacological research 115, (2017): 299-308. [PubMed Link] | [ Full text ]
  • Wang, X.;Xu, M.;Frank, J.A.;Ke, Z.J.;Luo, J. "Thiamine deficiency induces endoplasmic reticulum stress and oxidative stress in human neurons derived from induced pluripotent stem cells." Toxicology and applied pharmacology 320, (2017): 26-31. [PubMed Link] | [ Full text ]
  • Liu, D.;Ke, Z.;Luo, J. "Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy." Molecular neurobiology (2016): [PubMed Link] | [ Full text ]
  • Ren, Z.;Yang, F.;Wang, X.;Wang, Y.;Xu, M.;Frank, J.A.;Ke, Z.J.;Zhang, Z.;Shi, X.;Luo, J. "Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation." Toxicology and applied pharmacology 308, (2016): 11-9. [PubMed Link] | [ Full text ]
  • Dai, J.;Van Wie, P.G.;Fai, L.Y.;Kim, D.;Wang, L.;Poyil, P.;Luo, J.;Zhang, Z. "Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells." Toxicology and applied pharmacology 311, (2016): 106-112. [PubMed Link] | [ Full text ]
  • Duncan, J.W.;Johnson, S.;Zhang, X.;Zheng, B.;Luo, J.;Ou, X.M.;Stockmeier, C.A.;Wang, J.M. "Up-Regulation of PKR Signaling Pathway by Ethanol Displays an Age of Onset-Dependent Relationship." Alcoholism, clinical and experimental research 40, 11 (2016): 2320-2328. [PubMed Link] | [ Full text ]
  • Xu, M.;Wang, S.;Qi, Y.;Chen, L.;Frank, J.A.;Yang, X.H.;Zhang, Z.;Shi, X.;Luo, J. "Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells." Molecular carcinogenesis 55, 5 (2016): 1002-11. [PubMed Link] | [ Full text ]
  • Kim, D.;Dai, J.;Park, Y.H.;Fai, L.Y.;Wang, L.;Pratheeshkumar, P.;Son, Y.O.;Kondo, K.;Xu, M.;Luo, J.;Shi, X.;Zhang, Z. "Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium." The Journal of biological chemistry 291, 31 (2016): 16271-81. [PubMed Link] | [ Full text ]
  • Xu, M.;Ren, Z.;Wang, X.;Comer, A.;Frank, J.A.;Ke, Z.J.;Huang, Y.;Zhang, Z.;Shi, X.;Wang, S.;Luo, J. "ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis." Molecular cancer 15, 1 (2016): 52. [PubMed Link] | [ Full text ]
  • Xu, M.;Wang, S.;Ren, Z.;Frank, J.A.;Yang, X.H.;Zhang, Z.;Ke, Z.J.;Shi, X.;Luo, J. "Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ." Oncotarget 7, 3 (2016): 3489-505. [PubMed Link] | [ Full text ]
  • Ren, Z.;Wang, X.;Xu, M.;Yang, F.;Frank, J.A.;Ke, Z.J.;Luo, J. "Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas." Oncotarget 7, 34 (2016): 54303-54316. [PubMed Link] | [ Full text ]
  • Wang, L.;Hitron, J.A.;Wise, J.T.;Son, Y.O.;Roy, R.V.;Kim, D.;Dai, J.;Pratheeshkumar, P.;Zhang, Z.;Xu, M.;Luo, J.;Shi, X. "Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-κB signalings in colorectal cancer cells." Toxicology and applied pharmacology 288, 2 (2015): 232-9. [PubMed Link] | [ Full text ]
  • Yang, F.;Luo, J. "Endoplasmic Reticulum Stress and Ethanol Neurotoxicity." Biomolecules 5, 4 (2015): 2538-53. [PubMed Link] | [ Full text ]
  • Son, Y.O.;Pratheeshkumar, P.;Roy, R.V.;Hitron, J.A.;Wang, L.;Divya, S.P.;Xu, M.;Luo, J.;Chen, G.;Zhang, Z.;Shi, X. "Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis." The Journal of biological chemistry 290, 45 (2015): 27090-100. [PubMed Link] | [ Full text ]
  • Wang, H.;Wang, X.;Ke, Z.J.;Comer, A.L.;Xu, M.;Frank, J.A.;Zhang, Z.;Shi, X.;Luo, J. "Tunicamycin-induced unfolded protein response in the developing mouse brain." Toxicology and applied pharmacology 283, 3 (2015): 157-67. [PubMed Link] | [ Full text ]
  • Huang, C.;Irwin, D.;Lin, Y.;Shang, Y.;He, L.;Kong, W.;Luo, J.;Yu, G. "Speckle contrast diffuse correlation tomography of complex turbid medium flow." Medical physics 42, 7 (2015): 4000-6. [PubMed Link] | [ Full text ]
  • Wang, F.;Yang, J.L.;Yu, K.K.;Xu, M.;Xu, Y.Z.;Chen, L.;Lu, Y.M.;Fang, H.S.;Wang, X.Y.;Hu, Z.Q.;Li, F.F.;An, L.K.;Luo, J.;Wang, S.Y. "Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma." Molecular cancer 14, (2015): 10. [PubMed Link] | [ Full text ]
  • Yong, Y.;Meng, Y.;Ding, H.;Fan, Z.;Tang, Y.;Zhou, C.;Luo, J.;Ke, Z.J. "PACT/RAX regulates the migration of cerebellar granule neurons in the developing cerebellum." Scientific reports 5, (2015): 7961. [PubMed Link] | [ Full text ]
  • Padmaja Divya, S.;Pratheeshkumar, P.;Son, Y.O.;Vinod Roy, R.;Andrew Hitron, J.;Kim, D.;Dai, J.;Wang, L.;Asha, P.;Huang, B.;Xu, M.;Luo, J.;Zhang, Z. "Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway." Toxicological sciences : an official journal of the Society of Toxicology 146, 2 (2015): 290-300. [PubMed Link] | [ Full text ]
  • Luo, J. "Effects of Ethanol on the Cerebellum: Advances and Prospects." Cerebellum (London, England) 14, 4 (2015): 383-5. [PubMed Link] | [ Full text ]
  • Ji, Z.;Fan, Z.;Zhang, Y.;Yu, R.;Yang, H.;Zhou, C.;Luo, J.;Ke, Z.J. "Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2." Journal of immunology (Baltimore, Md. : 1950) 193, 5 (2014): 2157-67. [PubMed Link] | [ Full text ]
  • Yong, Y.;Luo, J.;Ke, Z.J. "dsRNA binding protein PACT/RAX in gene silencing, development and diseases." Frontiers in biology 9, 5 (2014): 382-388. [PubMed Link] |
  • Ke, Z.J.;Luo, J. "Response to Comment on "Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2"." Journal of immunology (Baltimore, Md. : 1950) 193, 10 (2014): 4755-6. [PubMed Link] | [ Full text ]
  • Chen, Z.;Ballar, P.;Fu, Y.;Luo, J.;Du, S.;Fang, S. "The E3 ubiquitin ligase gp78 protects against ER stress in zebrafish liver." Journal of genetics and genomics = Yi chuan xue bao 41, 7 (2014): 357-68. [PubMed Link] | [ Full text ]
  • Wang, H.;Ke, Z.;Alimov, A.;Xu, M.;Frank, J.A.;Fang, S.;Luo, J. "Spatiotemporal expression of MANF in the developing rat brain." PloS one 9, 2 (2014): e90433. [PubMed Link] | [ Full text ]
  • Baldwin, L.A.;Hoff, J.T.;Lefringhouse, J.;Zhang, M.;Jia, C.;Liu, Z.;Erfani, S.;Jin, H.;Xu, M.;She, Q.B.;Van Nagell, J.R.;Wang, C.;Chen, L.;Plattner, R.;Kaetzel, D.M.;Luo, J.;Lu, M.;West, D.;Liu, C.;Ueland, F.R.;Drapkin, R.;Zhou, B.P.;Yang, X.H. "CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling." Oncotarget 5, 23 (2014): 12203-17. [PubMed Link] | [ Full text ]
  • Lu, Y.;Ni, F.;Xu, M.;Yang, J.;Chen, J.;Chen, Z.;Wang, X.;Luo, J.;Wang, S. "Alcohol promotes mammary tumor growth through activation of VEGF-dependent tumor angiogenesis." Oncology letters 8, 2 (2014): 673-678. [PubMed Link] |
  • Luo, J. "Autophagy and ethanol neurotoxicity." Autophagy 10, 12 (2014): 2099-108. [PubMed Link] | [ Full text ]
  • Wang, L.;Kuang, L.;Hitron, J.A.;Son, Y.O.;Wang, X.;Budhraja, A.;Lee, J.C.;Pratheeshkumar, P.;Chen, G.;Zhang, Z.;Luo, J.;Shi, X. "Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression." Toxicology and applied pharmacology 272, 1 (2013): 108-16. [PubMed Link] | [ Full text ]
  • Wang, H.;Bower, K.A.;Frank, J.A.;Xu, M.;Luo, J. "Hypoxic preconditioning alleviates ethanol neurotoxicity: the involvement of autophagy." Neurotoxicity research 24, 4 (2013): 472-7. [PubMed Link] | [ Full text ]
  • Alimov, A.;Wang, H.;Liu, M.;Frank, J.A.;Xu, M.;Ou, X.;Luo, J. "Expression of autophagy and UPR genes in the developing brain during ethanol-sensitive and resistant periods." Metabolic brain disease 28, 4 (2013): 667-76. [PubMed Link] | [ Full text ]
  • Yang, Y.;Wang, H.;Wang, S.;Xu, M.;Liu, M.;Liao, M.;Frank, J.A.;Adhikari, S.;Bower, K.A.;Shi, X.;Ma, C.;Luo, J. "GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells." International journal of oncology 41, 5 (2012): 1782-8. [PubMed Link] | [ Full text ]
  • Chen, G.;Ke, Z.;Xu, M.;Liao, M.;Wang, X.;Qi, Y.;Zhang, T.;Frank, J.A.;Bower, K.A.;Shi, X.;Luo, J. "Autophagy is a protective response to ethanol neurotoxicity." Autophagy 8, 11 (2012): 1577-89. [PubMed Link] | [ Full text ]
  • Xu, M.;Chen, G.;Fu, W.;Liao, M.;Frank, J.A.;Bower, K.A.;Fang, S.;Zhang, Z.;Shi, X.;Luo, J. "Ethanol disrupts vascular endothelial barrier: implication in cancer metastasis." Toxicological sciences : an official journal of the Society of Toxicology 127, 1 (2012): 42-53. [PubMed Link] | [ Full text ]
  • Luo, J. "Mechanisms of ethanol-induced death of cerebellar granule cells." Cerebellum (London, England) 11, 1 (2012): 145-54. [PubMed Link] | [ Full text ]
  • Luo, J. "The role of GSK3beta in the development of the central nervous system." Frontiers in biology 7, 3 (2012): 212-220. [PubMed Link] |
  • Wang, S.;Xu, M.;Li, F.;Wang, X.;Bower, K.A.;Frank, J.A.;Lu, Y.;Chen, G.;Zhang, Z.;Ke, Z.;Shi, X.;Luo, J. "Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1." Breast cancer research and treatment 133, 3 (2012): 1037-48. [PubMed Link] | [ Full text ]
  • Budhraja, A.;Gao, N.;Zhang, Z.;Son, Y.O.;Cheng, S.;Wang, X.;Ding, S.;Hitron, A.;Chen, G.;Luo, J.;Shi, X. "Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo." Molecular cancer therapeutics 11, 1 (2012): 132-42. [PubMed Link] | [ Full text ]
  • Wang, L.;Son, Y.O.;Ding, S.;Wang, X.;Hitron, J.A.;Budhraja, A.;Lee, J.C.;Lin, Q.;Poyil, P.;Zhang, Z.;Luo, J.;Shi, X. "Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway." Toxicological sciences : an official journal of the Society of Toxicology 130, 2 (2012): 269-80. [PubMed Link] | [ Full text ]
  • Zhang, T.;Qi, Y.;Liao, M.;Xu, M.;Bower, K.A.;Frank, J.A.;Shen, H.M.;Luo, J.;Shi, X.;Chen, G. "Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation." Toxicological sciences : an official journal of the Society of Toxicology 130, 2 (2012): 298-308. [PubMed Link] | [ Full text ]
  • Wang, L.;Chen, F.;Zhang, Z.;Chen, G.;Luo, J.;Shi, X. "Cancer stem cells in the mechanism of metal carcinogenesis." Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 31, 3 (2012): 245-63. [PubMed Link] | [ Full text ]
  • Pratheeshkumar, P.;Son, Y.O.;Budhraja, A.;Wang, X.;Ding, S.;Wang, L.;Hitron, A.;Lee, J.C.;Kim, D.;Divya, S.P.;Chen, G.;Zhang, Z.;Luo, J.;Shi, X. "Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis." PloS one 7, 12 (2012): e52279. [PubMed Link] | [ Full text ]
  • Sun, L.;Wang, X.;Yao, H.;Li, W.;Son, Y.O.;Luo, J.;Liu, J.;Zhang, Z. "Reactive oxygen species mediate Cr(VI)-induced S phase arrest through p53 in human colon cancer cells." Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 31, 2 (2012): 95-107. [PubMed Link] | [ Full text ]
  • Xu, M.;Chen, G.;Wang, S.;Liao, M.;Frank, J.A.;Bower, K.A.;Zhang, Z.;Shi, X.;Luo, J. "Double-stranded RNA-dependent protein kinase regulates the motility of breast cancer cells." PloS one 7, 10 (2012): e47721. [PubMed Link] | [ Full text ]
  • Pratheeshkumar, P.;Budhraja, A.;Son, Y.O.;Wang, X.;Zhang, Z.;Ding, S.;Wang, L.;Hitron, A.;Lee, J.C.;Xu, M.;Chen, G.;Luo, J.;Shi, X. "Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways." PloS one 7, 10 (2012): e47516. [PubMed Link] | [ Full text ]
  • Wang, X.;Ke, Z.;Chen, G.;Xu, M.;Bower, K.A.;Frank, J.A.;Zhang, Z.;Shi, X.;Luo, J. "Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress." PloS one 7, 5 (2012): e38075. [PubMed Link] | [ Full text ]
  • Ke, Z.;Wang, X.;Liu, Y.;Fan, Z.;Chen, G.;Xu, M.;Bower, K.A.;Frank, J.A.;Li, M.;Fang, S.;Shi, X.;Luo, J. "Ethanol induces endoplasmic reticulum stress in the developing brain." Alcoholism, clinical and experimental research 35, 9 (2011): 1574-83. [PubMed Link] | [ Full text ]
  • Ke, Z.;Liu, Y.;Wang, X.;Fan, Z.;Chen, G.;Xu, M.;Bower, K.A.;Frank, J.A.;Ou, X.;Shi, X.;Luo, J. "Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain." Journal of neuroscience research 89, 10 (2011): 1676-84. [PubMed Link] | [ Full text ]
  • Zhang, Z.;Li, W.;Cheng, S.;Yao, H.;Zhang, F.;Chang, Q.;Ke, Z.;Wang, X.;Son, Y.O.;Luo, J.;Shi, X. "Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes." Toxicology and applied pharmacology 253, 3 (2011): 235-43. [PubMed Link] | [ Full text ]
  • Xu, M.;Bower, K.A.;Wang, S.;Frank, J.A.;Chen, G.;Ding, M.;Wang, S.;Shi, X.;Ke, Z.;Luo, J. "Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2." Molecular cancer 9, (2010): 285. [PubMed Link] | [ Full text ]
  • Wang, X.;Meng, D.;Chang, Q.;Pan, J.;Zhang, Z.;Chen, G.;Ke, Z.;Luo, J.;Shi, X. "Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway." Environmental health perspectives 118, 5 (2010): 627-34. [PubMed Link] | [ Full text ]
  • Xu, M.;Bower, K.A.;Chen, G.;Shi, X.;Dong, Z.;Ke, Z.;Luo, J. "Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin." Alcoholism, clinical and experimental research 34, 5 (2010): 751-60. [PubMed Link] | [ Full text ]
  • Luo, J. "Lithium-mediated protection against ethanol neurotoxicity." Frontiers in neuroscience 4, (2010): 41. [PubMed Link] | [ Full text ]
  • Chen, G.;Luo, J. "Anthocyanins: are they beneficial in treating ethanol neurotoxicity?" Neurotoxicity research 17, 1 (2010): 91-101. [PubMed Link] | [ Full text ]
  • Cheng, S.;Gao, N.;Zhang, Z.;Chen, G.;Budhraja, A.;Ke, Z.;Son, Y.O.;Wang, X.;Luo, J.;Shi, X. "Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax." Clinical cancer research : an official journal of the American Association for Cancer Research 16, 23 (2010): 5679-91. [PubMed Link] | [ Full text ]
  • Luo, J. "GSK3beta in ethanol neurotoxicity." Molecular neurobiology 40, 2 (2009): 108-21. [PubMed Link] | [ Full text ]
  • Chen, G.;Bower, K.A.;Xu, M.;Ding, M.;Shi, X.;Ke, Z.J.;Luo, J. "Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta." Neurotoxicity research 15, 4 (2009): 321-31. [PubMed Link] | [ Full text ]
  • Yao, H.;Wang, H.;Zhang, Z.;Jiang, B.H.;Luo, J.;Shi, X. "Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells." International journal of cancer 123, 6 (2008): 1255-61. [PubMed Link] | [ Full text ]
  • Yao, H.;Guo, L.;Jiang, B.H.;Luo, J.;Shi, X. "Oxidative stress and chromium(VI) carcinogenesis." Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 27, 2 (2008): 77-88. [PubMed Link] | [ Full text ]