John C Gant, Ph.D.

PubMed Publications: 

  • Frazier, H.N.;Maimaiti, S.;Anderson, K.L.;Brewer, L.D.;Gant, J.C.;Porter, N.M.;Thibault, O. "Calcium's role as nuanced modulator of cellular physiology in the brain." Biochemical and biophysical research communications 483, 4 (2017): 981-987. [PubMed Link] | [ Full text ]
  • Maimaiti, S.;Anderson, K.L.;Demoll, C.;Brewer, L.D.;Rauh, B.A.;Gant, J.C.;Blalock, E.M.;Porter, N.M.;Thibault, O. "Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging." The journals of gerontology. Series A, Biological sciences and medical sciences 71, 1 (2016): 30-9. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Kadish, I.;Blalock, E.M.;Thibault, O.;Porter, N.M.;Landfield, P.W. "Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 30 (2015): 10878-87. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Blalock, E.M.;Chen, K.C.;Kadish, I.;Porter, N.M.;Norris, C.M.;Thibault, O.;Landfield, P.W. "FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?" European journal of pharmacology 739, (2014): 74-82. [PubMed Link] | [ Full text ]
  • Furman, J.L.;Sama, D.M.;Gant, J.C.;Beckett, T.L.;Murphy, M.P.;Bachstetter, A.D.;Van Eldik, L.J.;Norris, C.M. "Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 46 (2012): 16129-40. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Chen, K.C.;Norris, C.M.;Kadish, I.;Thibault, O.;Blalock, E.M.;Porter, N.M.;Landfield, P.W. "Disrupting function of FK506-binding protein 1b/12.6 induces the Ca¬≤+-dysregulation aging phenotype in hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 5 (2011): 1693-703. [PubMed Link] | [ Full text ]
  • Blalock, E.M.;Phelps, J.T.;Pancani, T.;Searcy, J.L.;Anderson, K.L.;Gant, J.C.;Popovic, J.;Avdiushko, M.G.;Cohen, D.A.;Chen, K.C.;Porter, N.M.;Thibault, O. "Effects of long-term pioglitazone treatment on peripheral and central markers of aging." PloS one 5, 4 (2010): e10405. [PubMed Link] | [ Full text ]
  • Kadish, I.;Thibault, O.;Blalock, E.M.;Chen, K.C.;Gant, J.C.;Porter, N.M.;Landfield, P.W. "Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 6 (2009): 1805-16. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Thibault, O. "Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization." Neurobiology of aging 30, 12 (2009): 2053-64. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Thibault, O.;Blalock, E.M.;Yang, J.;Bachstetter, A.;Kotick, J.;Schauwecker, P.E.;Hauser, K.F.;Smith, G.M.;Mervis, R.;Li, Y.;Barnes, G.N. "Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy." Epilepsia 50, 4 (2009): 629-45. [PubMed Link] | [ Full text ]
  • Thibault, O.;Gant, J.C.;Landfield, P.W. "Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store." Aging cell 6, 3 (2007): 307-17. [PubMed Link] | [ Full text ]
  • Gant, J.C.;Sama, M.M.;Landfield, P.W.;Thibault, O. "Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release." The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 13 (2006): 3482-90. [PubMed Link] | [ Full text ]