Hollie Swanson, Ph.D.

Bio / Education: 

Ph.D., 1991, Purdue University, West Lafayette, IN
Food Science/Toxicology

M.S., 1988, Oregon State University, Corvallis, OR
Food Science/Food Toxicology

B.S., 1985, South Dakota State University,
Brookings, SD, Chemistry

Research Description: 

As a professor of a flagship, land grant institution, I enjoy being engaged in all three missions of the university, education, research and service.

My research interests in the past 20 years have focused on environmental toxicology, drug metabolism and nuclear receptors-particularly, the aryl hydrocarbon receptor. In the past several years, I have been developing an interest in the medicinal properties of natural products, such as a number of flavonoids. Some of these interact with the aryl hydrocarbon receptor and with other receptors. This is an exciting area of drug discovery. I am working on a book on this topic.

My educational activities are primarily centered around pharmacology. I teach pharmacology to medical, dental, graduate and undergraduate students. I have developed a new course this year that is focused on undergraduate students and is designed to cover the fundamentals of pharmacology using lectures and case based studies. It is my hope that this course can help pre-professional students better prepare for their future careers. I am also developing a new course that is designed to engage students in learning about their career options and how to develop good professional skills.

My service activities have taken me in many unexpected areas. I spent three years learning about drugs in horses serving on Kentucky's Equine Drug Research Council. This year, I have the privilege of working with my colleagues in the College of Medicine and serving as the Chair of our Faculty Council.

PubMed Publications: 

  • Swanson, H.I.;Choi, E.Y.;Helton, W.B.;Gairola, C.G.;Valentino, J. "Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma." Oral surgery, oral medicine, oral pathology and oral radiology 117, 2 (2014): 214-20. [PubMed Link] | [ Full text ]
  • Baker, N.A.;Karounos, M.;English, V.;Fang, J.;Wei, Y.;Stromberg, A.;Sunkara, M.;Morris, A.J.;Swanson, H.I.;Cassis, L.A. "Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice." Environmental health perspectives 121, 1 (2013): 105-10. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Wada, T.;Xie, W.;Renga, B.;Zampella, A.;Distrutti, E.;Fiorucci, S.;Kong, B.;Thomas, A.M.;Guo, G.L.;Narayanan, R.;Yepuru, M.;Dalton, J.T.;Chiang, J.Y. "Role of nuclear receptors in lipid dysfunction and obesity-related diseases." Drug metabolism and disposition: the biological fate of chemicals 41, 1 (2013): 1-11. [PubMed Link] | [ Full text ]
  • Moirangthem, V.;Katz, W.S.;Su, W.;Choi, E.Y.;Dingle, R.W.;Zeigler, G.M.;Everson, W.V.;Jennings, C.D.;Gong, M.;Swanson, H.I. "Impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cutaneous wound healing." Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 65, 1-2 (2013): 61-7. [PubMed Link] | [ Full text ]
  • Choi, E.Y.;Lee, H.;Dingle, R.W.;Kim, K.B.;Swanson, H.I. "Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor." Molecular pharmacology 81, 1 (2012): 3-11. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Njar, V.C.;Yu, Z.;Castro, D.J.;Gonzalez, F.J.;Williams, D.E.;Huang, Y.;Kong, A.N.;Doloff, J.C.;Ma, J.;Waxman, D.J.;Scott, E.E. "Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy." Drug metabolism and disposition: the biological fate of chemicals 38, 4 (2010): 539-44. [PubMed Link] | [ Full text ]
  • Ray, S.;Swanson, H.I. "Activation of the aryl hydrocarbon receptor by TCDD inhibits senescence: a tumor promoting event?" Biochemical pharmacology 77, 4 (2009): 681-8. [PubMed Link] | [ Full text ]
  • Puppala, D.;Lee, H.;Kim, K.B.;Swanson, H.I. "Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention." Molecular pharmacology 73, 4 (2008): 1064-71. [PubMed Link] | [ Full text ]
  • Puppala, D.;Gairola, C.G.;Swanson, H.I. "Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation." Carcinogenesis 28, 3 (2007): 639-47. [PubMed Link] | [ Full text ]
  • Wu, R.;Zhang, L.;Hoagland, M.S.;Swanson, H.I. "Lack of the aryl hydrocarbon receptor leads to impaired activation of AKT/protein kinase B and enhanced sensitivity to apoptosis induced via the intrinsic pathway." The Journal of pharmacology and experimental therapeutics 320, 1 (2007): 448-57. [PubMed Link] | [ Full text ]
  • Zhang, L.;Wu, R.;Dingle, R.W.;Gairola, C.G.;Valentino, J.;Swanson, H.I. "Cigarette smoke condensate and dioxin suppress culture shock induced senescence in normal human oral keratinocytes." Oral oncology 43, 7 (2007): 693-700. [PubMed Link] | [ Full text ]
  • Hoagland, M.S.;Hoagland, E.M.;Swanson, H.I. "The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor." The Journal of pharmacology and experimental therapeutics 314, 2 (2005): 603-10. [PubMed Link] | [ Full text ]
  • Wache, S.C.;Hoagland, E.M.;Zeigler, G.;Swanson, H.I. "Role of arginine residues 14 and 15 in dictating DNA binding stability and transactivation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator heterodimer." Gene expression 12, 4-6 (2005): 231-43. [PubMed Link] | [ Full text ]
  • Swanson, H.I. "Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective." Chemico-biological interactions 149, 2-3 (2004): 69-79. [PubMed Link] | [ Full text ]
  • Ray, S.S.;Swanson, H.I. "Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a." The Journal of biological chemistry 279, 26 (2004): 27187-93. [PubMed Link] | [ Full text ]
  • Ray, S.S.;Swanson, H.I. "Alteration of keratinocyte differentiation and senescence by the tumor promoter dioxin." Toxicology and applied pharmacology 192, 2 (2003): 131-45. [PubMed Link] | [ Full text ]
  • Swanson, H.I. "DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation." Chemico-biological interactions 141, 1-2 (2002): 63-76. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Whitelaw, M.L.;Petrulis, J.R.;Perdew, G.H. "Use of 125I 4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior." Journal of biochemical and molecular toxicology 16, 6 (2002): 298-310. [PubMed Link] |
  • Heid, S.E.;Walker, M.K.;Swanson, H.I. "Correlation of cardiotoxicity mediated by halogenated aromatic hydrocarbons to aryl hydrocarbon receptor activation." Toxicological sciences : an official journal of the Society of Toxicology 61, 1 (2001): 187-96. [PubMed Link] | [ Full text ]
  • Walker, M.K.;Heid, S.E.;Smith, S.M.;Swanson, H.I. "Molecular characterization and developmental expression of the aryl hydrocarbon receptor from the chick embryo." Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 126, 3 (2000): 305-19. [PubMed Link] |
  • Klinge, C.M.;Kaur, K.;Swanson, H.I. "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1." Archives of biochemistry and biophysics 373, 1 (2000): 163-74. [PubMed Link] | [ Full text ]
  • Heid, S.E.;Pollenz, R.S.;Swanson, H.I. "Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor." Molecular pharmacology 57, 1 (2000): 82-92. [PubMed Link] | [ Full text ]
  • Klinge, C.M.;Bowers, J.L.;Kulakosky, P.C.;Kamboj, K.K.;Swanson, H.I. "The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements." Molecular and cellular endocrinology 157, 1-2 (1999): 105-19. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Yang, J.H. "Specificity of DNA binding of the c-Myc/Max and ARNT/ARNT dimers at the CACGTG recognition site." Nucleic acids research 27, 15 (1999): 3205-12. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Yang, J.H. "The aryl hydrocarbon receptor interacts with transcription factor IIB." Molecular pharmacology 54, 4 (1998): 671-7. [PubMed Link] | [ Full text ]
  • Byrd DM, 3rd;Allen, D.O.;Beamer, R.L.;Besch HR, J.;Bylund, D.B.;Doull, J.;Fleming, W.W.;Fries, A.;Guengerich, F.P.;Hornbrook, R.;Lasagna, L.;Lum, B.K.;Michaelis, E.K.;Morgan, E.T.;Poland, A.;Rozman, K.K.;Smith, J.B.;Swanson, H.I.;Waddell, W.;Wilson, J.D. "The dose-response model for dioxin." Risk analysis : an official publication of the Society for Risk Analysis 18, 1 (1998): 1-2. [PubMed Link] |
  • Swanson, H.I.;Yang, J.H. "Mapping the protein/DNA contact sites of the Ah receptor and Ah receptor nuclear translocator." The Journal of biological chemistry 271, 49 (1996): 31657-65. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Chan, W.K.;Bradfield, C.A. "DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins." The Journal of biological chemistry 270, 44 (1995): 26292-302. [PubMed Link] | [ Full text ]
  • Bank, P.A.;Yao, E.F.;Swanson, H.I.;Tullis, K.;Denison, M.S. "DNA binding of the transformed guinea pig hepatic Ah receptor complex: identification and partial characterization of two high-affinity DNA-binding forms." Archives of biochemistry and biophysics 317, 2 (1995): 439-48. [PubMed Link] | [ Full text ]
  • Dolwick, K.M.;Swanson, H.I.;Bradfield, C.A. "In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition." Proceedings of the National Academy of Sciences of the United States of America 90, 18 (1993): 8566-70. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Bradfield, C.A. "The AH-receptor: genetics, structure and function." Pharmacogenetics 3, 5 (1993): 213-30. [PubMed Link] |
  • Swanson, H.I.;Tullis, K.;Denison, M.S. "Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: evidence for two distinct heteromeric DNA-binding forms." Biochemistry 32, 47 (1993): 12841-9. [PubMed Link] |
  • Dolwick, K.M.;Schmidt, J.V.;Carver, L.A.;Swanson, H.I.;Bradfield, C.A. "Cloning and expression of a human Ah receptor cDNA." Molecular pharmacology 44, 5 (1993): 911-7. [PubMed Link] | [ Full text ]
  • Schafer, M.W.;Madhukar, B.V.;Swanson, H.I.;Tullis, K.;Denison, M.S. "Protein kinase C is not involved in Ah receptor transformation and DNA binding." Archives of biochemistry and biophysics 307, 2 (1993): 267-71. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Perdew, G.H. "Half-life of aryl hydrocarbon receptor in Hepa 1 cells: evidence for ligand-dependent alterations in cytosolic receptor levels." Archives of biochemistry and biophysics 302, 1 (1993): 167-74. [PubMed Link] | [ Full text ]
  • Swanson, H.I.;Perdew, G.H. "Detection of the Ah receptor in rainbow trout: use of 2-azido-3- 125I iodo-7,8-dibromodibenzo-p-dioxin in cell culture." Toxicology letters 58, 1 (1991): 85-95. [PubMed Link] |
  • Fong, A.T.;Swanson, H.I.;Dashwood, R.H.;Williams, D.E.;Hendricks, J.D.;Bailey, G.S. "Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation." Biochemical pharmacology 39, 1 (1990): 19-26. [PubMed Link] | [ Full text ]