Frédérique Batifoulier Yiannikouris, Ph.D.

Research Description: 

‘’The epidemic of obesity, currently affecting more than 30% of the population in the United States, has contributed to a dramatic rise in the prevalence of hypertension. Anti-hypertensive drugs are commonly used to treat hypertension but evidence indicates that the mortality rate is fully 42% higher in the hypertensive than in the normotensive population, underscoring the severity of the problem. According to recent findings released from the National Heart Lung and Blood Institute (NHLBI), a blood pressure below 120 mmHg decreases the risk of cardiovascular diseases in adults. In this context, the identification of novel molecules/receptors involved in obesity and hypertension will allow us to better understand the link between obesity and hypertension and find novel therapeutic treatments for these highly prevalent diseases. Adipose tissue is an important source of elevated circulating concentrations of AngII, which contributes to hypertension in obese mice. While examining the component of the renin angiotensin system in adipocytes, I found that adipose tissue expresses prorenin receptor (PRR). Previous studies focused on the functional role of PRR brain and kidney have involved PRR in the regulation of blood pressure and in the activation of an intracellular pathway involved in hypertrophy, fibrosis, contractility and apoptosis. Recent studies have also suggested a role of PRR in Wnt signaling and V-ATPase activity. My research program focuses on the determination of the role of PRR in fat mass growth, the mechanism by which PRR is involved in obesity and its role in the regulation of blood pressure.’’

Selected Publications: 

"Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice"
Chia Hua Wu, Shayan Mohammadmoradi, Joel Thompson, Wen MingGong, Genevieve Nguyen, Frédérique Yiannikouris. HYPERTENSIONAHA.115.06954

Published online before print May 16, 2016

"An obligatory role for neurotensin in high-fat-diet-induced obesity."

Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou,Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander,Jing Chen, Haining Zhu,Timothy Fahrenholz, Richard M. Higashi,Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W.-M.Fan, Heidi L.Weiss, Paul R.Dobner, Olle Melander, Jianhang Jia et al.

Nature (2016) doi:10.1038/nature17662
Received 24 February 2015 Accepted 10 March 2016 Published online 11 May 2016

Editorial Mentions

1. Grobe J.L, Rahmouni K. Editorial focus: The adipose/circulating renin-angiotensin system cross-talk enters a new dimension. Comments on: Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice. 2012. Hypertension. 60(6):1389-90.

2. Grobe J.L, Rahmouni K. Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. 2012. "Am J Physiol Regul Integr Comp Physiol; 302(2):R242-3.

PubMed Publications: 

  • Li, J.;Song, J.;Zaytseva, Y.Y.;Liu, Y.;Rychahou, P.;Jiang, K.;Starr, M.E.;Kim, J.T.;Harris, J.W.;Yiannikouris, F.B.;Katz, W.S.;Nilsson, P.M.;Orho-Melander, M.;Chen, J.;Zhu, H.;Fahrenholz, T.;Higashi, R.M.;Gao, T.;Morris, A.J.;Cassis, L.A.;Fan, T.W.;Weiss, H.L.;Dobner, P.R.;Melander, O.;Jia, J.;Evers, B.M. "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
  • Wu, C.H.;Mohammadmoradi, S.;Thompson, J.;Su, W.;Gong, M.;Nguyen, G.;Yiannikouris, F. "Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice." Hypertension (Dallas, Tex. : 1979) 68, 1 (2016): 213-9. [PubMed Link] | [ Full text ]
  • Shoemaker, R.;Yiannikouris, F.;Thatcher, S.;Cassis, L. "ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice." American journal of physiology. Endocrinology and metabolism 309, 7 (2015): E621-31. [PubMed Link] | [ Full text ]
  • Yiannikouris, F.;Wang, Y.;Shoemaker, R.;Larian, N.;Thompson, J.;English, V.L.;Charnigo, R.;Su, W.;Gong, M.;Cassis, L.A. "Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice." Hypertension (Dallas, Tex. : 1979) 66, 4 (2015): 836-42. [PubMed Link] | [ Full text ]
  • Baker, N.A.;Shoemaker, R.;English, V.;Larian, N.;Sunkara, M.;Morris, A.J.;Walker, M.;Yiannikouris, F.;Cassis, L.A. "Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice." Environmental health perspectives 123, 10 (2015): 944-50. [PubMed Link] | [ Full text ]
  • Wang, Y.;Shoemaker, R.;Thatcher, S.E.;Batifoulier-Yiannikouris, F.;English, V.L.;Cassis, L.A. "Administration of 17β-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism." American journal of physiology. Endocrinology and metabolism 308, 12 (2015): E1066-75. [PubMed Link] | [ Full text ]
  • Thatcher, S.E.;Zhang, X.;Howatt, D.A.;Yiannikouris, F.;Gurley, S.B.;Ennis, T.;Curci, J.A.;Daugherty, A.;Cassis, L.A. "Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms." Arteriosclerosis, thrombosis, and vascular biology 34, 12 (2014): 2617-23. [PubMed Link] | [ Full text ]
  • Putnam, K.;Batifoulier-Yiannikouris, F.;Bharadwaj, K.G.;Lewis, E.;Karounos, M.;Daugherty, A.;Cassis, L.A. "Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice." Endocrinology 153, 10 (2012): 4677-86. [PubMed Link] | [ Full text ]
  • Putnam, K.;Shoemaker, R.;Yiannikouris, F.;Cassis, L.A. "The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome." American journal of physiology. Heart and circulatory physiology 302, 6 (2012): H1219-30. [PubMed Link] | [ Full text ]
  • Gupte, M.;Thatcher, S.E.;Boustany-Kari, C.M.;Shoemaker, R.;Yiannikouris, F.;Zhang, X.;Karounos, M.;Cassis, L.A. "Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice." Arteriosclerosis, thrombosis, and vascular biology 32, 6 (2012): 1392-9. [PubMed Link] | [ Full text ]
  • Yiannikouris, F.;Karounos, M.;Charnigo, R.;English, V.L.;Rateri, D.L.;Daugherty, A.;Cassis, L.A. "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice." American journal of physiology. Regulatory, integrative and comparative physiology 302, 2 (2012): R244-51. [PubMed Link] | [ Full text ]
  • Yiannikouris, F.;Gupte, M.;Putnam, K.;Thatcher, S.;Charnigo, R.;Rateri, D.L.;Daugherty, A.;Cassis, L.A. "Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice." Hypertension (Dallas, Tex. : 1979) 60, 6 (2012): 1524-30. [PubMed Link] | [ Full text ]
  • Yiannikouris, F.;Gupte, M.;Putnam, K.;Cassis, L. "Adipokines and blood pressure control." Current opinion in nephrology and hypertension 19, 2 (2010): 195-200. [PubMed Link] | [ Full text ]
  • Police, S.B.;Putnam, K.;Thatcher, S.;Batifoulier-Yiannikouris, F.;Daugherty, A.;Cassis, L.A. "Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms." American journal of physiology. Heart and circulatory physiology 298, 6 (2010): H1932-8. [PubMed Link] | [ Full text ]
  • Thatcher, S.;Yiannikouris, F.;Gupte, M.;Cassis, L. "The adipose renin-angiotensin system: role in cardiovascular disease." Molecular and cellular endocrinology 302, 2 (2009): 111-7. [PubMed Link] |
  • Henriques, T.;Zhang, X.;Yiannikouris, F.B.;Daugherty, A.;Cassis, L.A. "Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice." Arteriosclerosis, thrombosis, and vascular biology 28, 7 (2008): 1251-6. [PubMed Link] | [ Full text ]
  • Cassis, L.A.;Police, S.B.;Yiannikouris, F.;Thatcher, S.E. "Local adipose tissue renin-angiotensin system." Current hypertension reports 10, 2 (2008): 93-8. [PubMed Link] |
  • Batifoulier, F.;Verny, M.A.;Besson, C.;Chanliaud, E.;Rémésy, C.;Demigné, C. "Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model." International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 77, 1 (2007): 46-56. [PubMed Link] | [ Full text ]
  • Batifoulier, F.;Verny, M.A.;Besson, C.;Demigné, C.;Rémésy, C. "Determination of thiamine and its phosphate esters in rat tissues analyzed as thiochromes on a RP-amide C16 column." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 816, 1-2 (2005): 67-72. [PubMed Link] | [ Full text ]
  • Brachet, P.;Chanson, A.;Demigné, C.;Batifoulier, F.;Alexandre-Gouabau, M.C.;Tyssandier, V.;Rock, E. "Age-associated B vitamin deficiency as a determinant of chronic diseases." Nutrition research reviews 17, 1 (2004): 55-68. [PubMed Link] | [ Full text ]
  • Batifoulier, F.;Mercier, Y.;Gatellier, P.;Renerre, M. "Influence of vitamin E on lipid and protein oxidation induced by H(2)O(2)-activated MetMb in microsomal membranes from turkey muscle." Meat science 61, 4 (2002): 389-95. [PubMed Link] | [ Full text ]