Elizabeth Head, Ph.D.

Bio / Education: 

B.Sc. 1991. University of Toronto, Neuroscience
M.A. 1992. University of Toronto, Psychology
Ph.D. 1997 University of Toronto, Collaborative Program in Neuroscience

Research Description: 

The goals of our research are to identify interventions that may prevent the onset and/or progression of Alzheimer disease and thus promote healthy brain aging. To do this our lab tests hypotheses using a canine model of human brain aging with a focus on testing combination treatment approaches, each approach targeting different pathological pathways associated with aging or Alzheimer disease. Canines naturally develop learning and memory impairments with age as well as similar types of brain pathology. Our studies are multidisciplinary and extend from magnetic resonance imaging (MRI), to testing cognitive function (learning and memory) and neurobiological studies (anatomical, genomics and proteomics). We currently are testing the hypothesis that vaccination with beta-amyloid peptide when combined with behavioral enrichment will lead to significant improvements in cognition and reductions in neuropathology in aged canines.

In parallel with studies that seek to identify new treatment options for healthy brain aging we are also characterizing changes in cognition, blood protein levels and white matter changes by magnetic resonance imaging in middle aged and older adults with Down syndrome. People with Down syndrome are at high risk for developing Alzheimer’s disease particularly after the age of 40 years due to their extra copy of chromosome 21. This NIH funded study is testing the hypothesis that frontal dysfunction may be an early sign of transition to dementia in adults with Down syndrome. In the future we hope to use promising treatment strategies developed in animal model systems and translating our research into human clinical trials for people with Down syndrome.

Grants: 

R01 AG031764 (Head, E)
03/15/09-2/28/14
National Institutes of Health (NIA)
Beta-Amyloid Immunization in a Canine Model of Aging
The goal of this project is to test the hypothesis that a combination treatment with beta-amyloid immunization with behavioral enrichment will improve cognition and reduce Alzheimer-disease like neuropathology in aged dogs.

R01 HD064993 (Head, E./Schmitt F.A. Co-PI)
09/01/09-08/31/14
National Institutes on Health (NICHD/NIA)
Eunice Kennedy Shriver National Institute of Child Health & Human Development
Aging of Frontal Structure and Function in Down Syndrome and Dementia

Selected Publications: 

Canine Model
Cotman, CW, Head, E. (2008). The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J. Alzheimers Dis. 15(4): 685-707.

Head, E., Pop, V., Vasilevko, V., Hill, M., Saing, T., Sarsoza, F., Nistor, M., Christie, L., Milton, S., Glabe, C., Barrett, E., Cribbs, D. (2008). A 2-Year Study with Fibrillar Aβ Immunization in Aged Canines: Effects on Cognitive Function and Brain Aβ. Journal of Neuroscience, 28: 3555-3566.

Opii,W.O., Joshi , G., Head, E., Milgram, N.W., Muggenburg, B.A., Klein, J.B., Pierce, W.M., Cotman, C.W., Butterfield, D.A.. (2008). Proteomic Identification of Brain Proteins in the Canine Model of Human Aging Following a Long-Term Treatment with Antioxidants and a Program of Behavioral Enrichment: Relevance to Alzheimer’s Disease. Neurobiology of Aging, 29(1): 51-70.

Milgram, N.W., Siwak-Tapp, C.T., Araujo, J., Head, E. (2006). Neuroprotective effects of cognitive enrichment. Ageing Research Reviews, 5: 354-369. Tapp, P.D., Head, K., Head, E., Milgram, N.W., Muggenburg, B.A., Su, M.-Y. (2006).

Application of an Automated Voxel-based Morphometry Technique to Assess Regional Gray and White Matter Brain Atrophy in a Canine Model of Aging. NeuroImage, 29(1): 234-244.

Milgram, N.W., Head, E., Zicker, SC., Ikeda-Douglas, C.J., Murphey, H. Muggenburg, B. Siwak, C., Tapp, D, Cotman, CW (2005). Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: A two-year longitudinal study. Neurobiology of Aging. 26:77-90.

Tapp, P.D., Siwak, C.T., Gao, F.Q., Choui, J.Y., Black, S.E., Head, E., Muggenburg, B.A., Cotman, C.W., Milgram, N.W., Su, M.-Y. 2004). Frontal lobe volume, function and Aβ Pathology in a canine model of aging. Journal of Neuroscience, 24(38): 8205-8213.

Dowling, A.L., Head, E. Antioxidants in the Canine Model of Human Aging. (2012) BBA - Molecular Basis of Disease, 1822(5):685-690.

Down syndrome

Lott, I.T., Doran, E., Nguyen, V., Tournay, A., Head, E., Gillen, D.L. (2011). Down Syndrome and Dementia: a Randomized, Controlled Trial of Antioxidant Supplementation. American Journal of Medical Genetics A., 155A(8): 1939-1948.

Cenini, G., Dowling, A.L.S., Beckett. T., Barone, E., Mancuso, C., Murphy, M.P., Levine, H., Lott, I.T., Schmitt, F.A., Butterfield, D.A., Head, E. (2012). Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Bioichim Biphys Acta, 1822(2): 130-138.

Head, E. Doran, E., Nistor, M., Schmitt, F.A., Haier, R.J., and Lott, I.T. (2011). Plasma Aβ as a function of age, level of intellectual disability and presence of dementia in Down syndrome. Journal of Alzheimer’s disease, 23(3): 391-398.

Head, E., Powell, D., Gold, B.T., Schmitt. F.A. Alzheimer’s Disease in Down syndrome. European Journal of Neurodegenerative Disease, in press.

PubMed Publications: 

  • Tramutola, A.;Di Domenico, F.;Barone, E.;Arena, A.;Giorgi, A.;Di Francesco, L.;Schininà, M.E.;Coccia, R.;Head, E.;Butterfield, D.A.;Perluigi, M. "Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology." Antioxidants & redox signaling 26, 7 (2017): 280-298. [PubMed Link] | [ Full text ]
  • Hainsworth, A.H.;Allan, S.M.;Boltze, J.;Cunningham, C.;Farris, C.;Head, E.;Ihara, M.;Isaacs, J.D.;Kalaria, R.N.;Lesnik Oberstein, S.A.;Moss, M.B.;Nitzsche, B.;Rosenberg, G.A.;Rutten, J.W.;Salkovic-Petrisic, M.;Troen, A.M. "Translational models for vascular cognitive impairment: a review including larger species." BMC medicine 15, 1 (2017): 16. [PubMed Link] | [ Full text ]
  • Davis, P.R.;Giannini, G.;Rudolph, K.;Calloway, N.;Royer, C.M.;Beckett, T.L.;Murphy, M.P.;Bresch, F.;Pagani, D.;Platt, T.;Wang, X.;Donovan, A.S.;Sudduth, T.L.;Lou, W.;Abner, E.;Kryscio, R.;Wilcock, D.M.;Barrett, E.G.;Head, E. "Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages." Neurobiology of aging 49, (2017): 86-99. [PubMed Link] | [ Full text ]
  • Doran, E.;Keator, D.;Head, E.;Phelan, M.J.;Kim, R.;Totoiu, M.;Barrio, J.R.;Small, G.W.;Potkin, S.G.;Lott, I.T. "Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP." Journal of Alzheimer's disease : JAD 56, 2 (2017): 459-470. [PubMed Link] | [ Full text ]
  • Barone, E.;Head, E.;Butterfield, D.A.;Perluigi, M. "HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology." Free radical biology & medicine (2016): [PubMed Link] | [ Full text ]
  • Day, R.J.;McCarty, K.L.;Ockerse, K.E.;Head, E.;Rohn, T.T. "Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain." Aging and disease 7, 3 (2016): 267-77. [PubMed Link] |
  • Jaeger, P.A.;Lucin, K.M.;Britschgi, M.;Vardarajan, B.;Huang, R.P.;Kirby, E.D.;Abbey, R.;Boeve, B.F.;Boxer, A.L.;Farrer, L.A.;Finch, N.;Graff-Radford, N.R.;Head, E.;Hofree, M.;Huang, R.;Johns, H.;Karydas, A.;Knopman, D.S.;Loboda, A.;Masliah, E.;Narasimhan, R.;Petersen, R.C.;Podtelezhnikov, A.;Pradhan, S.;Rademakers, R.;Sun, C.H.;Younkin, S.G.;Miller, B.L.;Ideker, T.;Wyss-Coray, T. "Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain." Molecular neurodegeneration 11, 1 (2016): 42. [PubMed Link] | [ Full text ]
  • Wilcock, D.M.;Schmitt, F.A.;Head, E. "Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome." Biochimica et biophysica acta 1862, 5 (2016): 909-14. [PubMed Link] | [ Full text ]
  • Youssef, S.A.;Capucchio, M.T.;Rofina, J.E.;Chambers, J.K.;Uchida, K.;Nakayama, H.;Head, E. "Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases." Veterinary pathology 53, 2 (2016): 327-48. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Powell, D.;Caban-Holt, A.;Jicha, G.;Robertson, W.;Gold, B.T.;Davis, R.;Abner, E.;Wilcock, D.M.;Schmitt, F.A.;Head, E. "(1)H-MRS metabolites in adults with Down syndrome: Effects of dementia." NeuroImage. Clinical 11, (2016): 728-35. [PubMed Link] | [ Full text ]
  • Fosso, M.Y.;McCarty, K.;Head, E.;Garneau-Tsodikova, S.;Levine H, 3rd "Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils." ACS chemical neuroscience 7, 2 (2016): 171-6. [PubMed Link] | [ Full text ]
  • Jaeger, P.A.;Lucin, K.M.;Britschgi, M.;Vardarajan, B.;Huang, R.P.;Kirby, E.D.;Abbey, R.;Boeve, B.F.;Boxer, A.L.;Farrer, L.A.;Finch, N.;Graff-Radford, N.R.;Head, E.;Hoffree, M.;Huang, R.;Johns, H.;Karydas, A.;Knopman, D.S.;Loboda, A.;Masliah, E.;Narasimhan, R.;Petersen, R.C.;Podtelezhnikov, A.;Pradhan, S.;Rademakers, R.;Sun, C.H.;Younkin, S.G.;Miller, B.L.;Ideker, T.;Wyss-Coray, T. "Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain." Molecular neurodegeneration 11, (2016): 31. [PubMed Link] | [ Full text ]
  • Anderson-Mooney, A.J.;Schmitt, F.A.;Head, E.;Lott, I.T.;Heilman, K.M. "Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms." Brain and cognition 104, (2016): 48-57. [PubMed Link] | [ Full text ]
  • Head, E.;Lott, I.T.;Wilcock, D.M.;Lemere, C.A. "Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology." Current Alzheimer research 13, 1 (2016): 18-29. [PubMed Link] | [ Full text ]
  • Tramutola, A.;Pupo, G.;Di Domenico, F.;Barone, E.;Arena, A.;Lanzillotta, C.;Broekaart, D.;Blarzino, C.;Head, E.;Butterfield, D.A.;Perluigi, M. "Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype." Journal of Alzheimer's disease : JAD 52, 1 (2016): 359-71. [PubMed Link] | [ Full text ]
  • Tanifum, E.A.;Ghaghada, K.;Vollert, C.;Head, E.;Eriksen, J.L.;Annapragada, A. "A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging." Journal of Alzheimer's disease : JAD 52, 2 (2016): 731-45. [PubMed Link] | [ Full text ]
  • Wilcock, D.M.;Hurban, J.;Helman, A.M.;Sudduth, T.L.;McCarty, K.L.;Beckett, T.L.;Ferrell, J.C.;Murphy, M.P.;Abner, E.L.;Schmitt, F.A.;Head, E. "Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease." Neurobiology of aging 36, 9 (2015): 2468-74. [PubMed Link] | [ Full text ]
  • Wang, L.S.;Naj, A.C.;Graham, R.R.;Crane, P.K.;Kunkle, B.W.;Cruchaga, C.;Murcia, J.D.;Cannon-Albright, L.;Baldwin, C.T.;Zetterberg, H.;Blennow, K.;Kukull, W.A.;Faber, K.M.;Schupf, N.;Norton, M.C.;Tschanz, J.T.;Munger, R.G.;Corcoran, C.D.;Rogaeva, E.;Lin, C.F.;Dombroski, B.A.;Cantwell, L.B.;Partch, A.;Valladares, O.;Hakonarson, H.;St George-Hyslop, P.;Green, R.C.;Goate, A.M.;Foroud, T.M.;Carney, R.M.;Larson, E.B.;Behrens, T.W.;Kauwe, J.S.;Haines, J.L.;Farrer, L.A.;Pericak-Vance, M.A.;Mayeux, R.;Schellenberg, G.D.;National Institute on Aging–Late-Onset Alzheimer’s Disease (NIA-LOAD) Family, S.;Alzheimer’s Disease Genetics, C.;Albert, M.S.;Albin, R.L.;Apostolova, L.G.;Arnold, S.E.;Barber, R.;Barmada, M.M.;Barnes, L.L.;Beach, T.G.;Becker, J.T.;Beecham, G.W.;Beekly, D.;Bennett, D.A.;Bigio, E.H.;Bird, T.D.;Blacker, D.;Boeve, B.F.;Bowen, J.D.;Boxer, A.;Burke, J.R.;Buxbaum, J.D.;Cairns, N.J.;Cao, C.;Carlson, C.S.;Carroll, S.L.;Chui, H.C.;Clark, D.G.;Cribbs, D.H.;Crocco, E.A.;DeCarli, C.;DeKosky, S.T.;Demirci, F.Y.;Dick, M.;Dickson, D.W.;Duara, R.;Ertekin-Taner, N.;Fallon, K.B.;Farlow, M.R.;Ferris, S.;Frosch, M.P.;Galasko, D.R.;Ganguli, M.;Gearing, M.;Geschwind, D.H.;Ghetti, B.;Gilbert, J.R.;Glass, J.D.;Graff-Radford, N.R.;Growdon, J.H.;Hamilton, R.L.;Hamilton-Nelson, K.L.;Harrell, L.E.;Head, E.;Honig, L.S.;Hulette, C.M.;Hyman, B.T.;Jarvik, G.P.;Jicha, G.A.;Jin, L.W.;Jun, G.;Kamboh, M.I.;Karydas, A.;Kaye, J.A.;Kim, R.;Koo, E.H.;Kowall, N.W.;Kramer, J.H.;Kramer, P.;LaFerla, F.M.;Lah, J.J.;Leverenz, J.B.;Levey, A.I.;Li, G.;Lieberman, A.P.;Lopez, O.L.;Lunetta, K.L.;Lyketsos, C.G.;Mack, W.J.;Marson, D.C.;Martin, E.R.;Martiniuk, F.;Mash, D.C.;Masliah, E.;McCormick, W.C.;McCurry, S.M.;McDavid, A.N.;McKee, A.C.;Mesulam, M.M.;Miller, B.L.;Miller, C.A.;Miller, J.W.;Montine, T.J.;Morris, J.C.;Murrell, J.R.;Olichney, J.M.;Parisi, J.E.;Perry, W.;Peskind, E.;Petersen, R.C.;Pierce, A.;Poon, W.W.;Potter, H.;Quinn, J.F.;Raj, A.;Raskind, M.;Reiman, E.M.;Reisberg, B.;Reitz, C.;Ringman, J.M.;Roberson, E.D.;Rosen, H.J.;Rosenberg, R.N.;Sano, M.;Saykin, A.J.;Schneider, J.A.;Schneider, L.S.;Seeley, W.W.;Smith, A.G.;Sonnen, J.A.;Spina, S.;Stern, R.A.;Tanzi, R.E.;Thornton-Wells, T.A.;Trojanowski, J.Q.;Troncoso, J.C.;Tsuang, D.W.;Van Deerlin, V.M.;Van Eldik, L.J.;Vardarajan, B.N.;Vinters, H.V.;Vonsattel, J.P.;Weintraub, S.;Welsh-Bohmer, K.A.;Williamson, J.;Wishnek, S.;Woltjer, R.L.;Wright, C.B.;Younkin, S.G.;Yu, C.E.;Yu, L. "Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States." JAMA neurology 72, 2 (2015): 209-16. [PubMed Link] | [ Full text ]
  • Di Domenico, F.;Pupo, G.;Mancuso, C.;Barone, E.;Paolini, F.;Arena, A.;Blarzino, C.;Schmitt, F.A.;Head, E.;Butterfield, D.A.;Perluigi, M. "Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease." Journal of Alzheimer's disease : JAD 44, 4 (2015): 1107-20. [PubMed Link] | [ Full text ]
  • Head, E.;Schmitt, F.A. "Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome?" Alzheimer's research & therapy 6, 5-8 (2014): 61. [PubMed Link] | [ Full text ]
  • Butterfield, D.A.;Di Domenico, F.;Swomley, A.M.;Head, E.;Perluigi, M. "Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain." The Biochemical journal 463, 2 (2014): 177-89. [PubMed Link] | [ Full text ]
  • Jullienne, A.;Roberts, J.M.;Pop, V.;Paul Murphy, M.;Head, E.;Bix, G.J.;Badaut, J. "Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 34, 10 (2014): 1637-45. [PubMed Link] | [ Full text ]
  • Izzo, N.J.;Xu, J.;Zeng, C.;Kirk, M.J.;Mozzoni, K.;Silky, C.;Rehak, C.;Yurko, R.;Look, G.;Rishton, G.;Safferstein, H.;Cruchaga, C.;Goate, A.;Cahill, M.A.;Arancio, O.;Mach, R.H.;Craven, R.;Head, E.;Levine H, 3rd;Spires-Jones, T.L.;Catalano, S.M. "Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity." PloS one 9, 11 (2014): e111899. [PubMed Link] | [ Full text ]
  • Cenini, G.;Fiorini, A.;Sultana, R.;Perluigi, M.;Cai, J.;Klein, J.B.;Head, E.;Butterfield, D.A. "An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach." Free radical biology & medicine 76, (2014): 89-95. [PubMed Link] | [ Full text ]
  • Vite, C.H.;Head, E. "Aging in the canine and feline brain." The Veterinary clinics of North America. Small animal practice 44, 6 (2014): 1113-29. [PubMed Link] | [ Full text ]
  • Naj, A.C.;Jun, G.;Reitz, C.;Kunkle, B.W.;Perry, W.;Park, Y.S.;Beecham, G.W.;Rajbhandary, R.A.;Hamilton-Nelson, K.L.;Wang, L.S.;Kauwe, J.S.;Huentelman, M.J.;Myers, A.J.;Bird, T.D.;Boeve, B.F.;Baldwin, C.T.;Jarvik, G.P.;Crane, P.K.;Rogaeva, E.;Barmada, M.M.;Demirci, F.Y.;Cruchaga, C.;Kramer, P.L.;Ertekin-Taner, N.;Hardy, J.;Graff-Radford, N.R.;Green, R.C.;Larson, E.B.;St George-Hyslop, P.H.;Buxbaum, J.D.;Evans, D.A.;Schneider, J.A.;Lunetta, K.L.;Kamboh, M.I.;Saykin, A.J.;Reiman, E.M.;De Jager, P.L.;Bennett, D.A.;Morris, J.C.;Montine, T.J.;Goate, A.M.;Blacker, D.;Tsuang, D.W.;Hakonarson, H.;Kukull, W.A.;Foroud, T.M.;Martin, E.R.;Haines, J.L.;Mayeux, R.P.;Farrer, L.A.;Schellenberg, G.D.;Pericak-Vance, M.A.;Alzheimer Disease Genetics, C.;Albert, M.S.;Albin, R.L.;Apostolova, L.G.;Arnold, S.E.;Barber, R.;Barnes, L.L.;Beach, T.G.;Becker, J.T.;Beekly, D.;Bigio, E.H.;Bowen, J.D.;Boxer, A.;Burke, J.R.;Cairns, N.J.;Cantwell, L.B.;Cao, C.;Carlson, C.S.;Carney, R.M.;Carrasquillo, M.M.;Carroll, S.L.;Chui, H.C.;Clark, D.G.;Corneveaux, J.;Cribbs, D.H.;Crocco, E.A.;DeCarli, C.;DeKosky, S.T.;Dick, M.;Dickson, D.W.;Duara, R.;Faber, K.M.;Fallon, K.B.;Farlow, M.R.;Ferris, S.;Frosch, M.P.;Galasko, D.R.;Ganguli, M.;Gearing, M.;Geschwind, D.H.;Ghetti, B.;Gilbert, J.R.;Glass, J.D.;Growdon, J.H.;Hamilton, R.L.;Harrell, L.E.;Head, E.;Honig, L.S.;Hulette, C.M.;Hyman, B.T.;Jicha, G.A.;Jin, L.W.;Karydas, A.;Kaye, J.A.;Kim, R.;Koo, E.H.;Kowall, N.W.;Kramer, J.H.;LaFerla, F.M.;Lah, J.J.;Leverenz, J.B.;Levey, A.I.;Li, G.;Lieberman, A.P.;Lin, C.F.;Lopez, O.L.;Lyketsos, C.G.;Mack, W.J.;Martiniuk, F.;Mash, D.C.;Masliah, E.;McCormick, W.C.;McCurry, S.M.;McDavid, A.N.;McKee, A.C.;Mesulam, M.;Miller, B.L.;Miller, C.A.;Miller, J.W.;Murrell, J.R.;Olichney, J.M.;Pankratz, V.S.;Parisi, J.E.;Paulson, H.L.;Peskind, E.;Petersen, R.C.;Pierce, A.;Poon, W.W.;Potter, H.;Quinn, J.F.;Raj, A.;Raskind, M.;Reisberg, B.;Ringman, J.M.;Roberson, E.D.;Rosen, H.J.;Rosenberg, R.N.;Sano, M.;Schneider, L.S.;Seeley, W.W.;Smith, A.G.;Sonnen, J.A.;Spina, S.;Stern, R.A.;Tanzi, R.E.;Thornton-Wells, T.A.;Trojanowski, J.Q.;Troncoso, J.C.;Valladares, O.;Van Deerlin, V.M.;Van Eldik, L.J.;Vardarajan, B.N.;Vinters, H.V.;Vonsattel, J.P.;Weintraub, S.;Welsh-Bohmer, K.A.;Williamson, J.;Wishnek, S.;Woltjer, R.L.;Wright, C.B.;Younkin, S.G.;Yu, C.E.;Yu, L. "Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study." JAMA neurology 71, 11 (2014): 1394-404. [PubMed Link] | [ Full text ]
  • Davis, P.R.;Head, E. "Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges." Frontiers in pharmacology 5, (2014): 47. [PubMed Link] | [ Full text ]
  • Di Domenico, F.;Pupo, G.;Tramutola, A.;Giorgi, A.;Schininà, M.E.;Coccia, R.;Head, E.;Butterfield, D.A.;Perluigi, M. "Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease." Free radical biology & medicine 71, (2014): 270-80. [PubMed Link] | [ Full text ]
  • Powell, D.;Caban-Holt, A.;Jicha, G.;Robertson, W.;Davis, R.;Gold, B.T.;Schmitt, F.A.;Head, E. "Frontal white matter integrity in adults with Down syndrome with and without dementia." Neurobiology of aging 35, 7 (2014): 1562-9. [PubMed Link] | [ Full text ]
  • Perluigi, M.;Pupo, G.;Tramutola, A.;Cini, C.;Coccia, R.;Barone, E.;Head, E.;Butterfield, D.A.;Di Domenico, F. "Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain." Biochimica et biophysica acta 1842, 7 (2014): 1144-53. [PubMed Link] | [ Full text ]
  • Rohn, T.T.;McCarty, K.L.;Love, J.E.;Head, E. "Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?" Journal of Parkinson's disease and Alzheimer's disease 1, 1 (2014): [PubMed Link] |
  • Marchese, M.;Cowan, D.;Head, E.;Ma, D.;Karimi, K.;Ashthorpe, V.;Kapadia, M.;Zhao, H.;Davis, P.;Sakic, B. "Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease." Journal of Alzheimer's disease : JAD 39, 1 (2014): 191-210. [PubMed Link] | [ Full text ]
  • Holler, C.J.;Davis, P.R.;Beckett, T.L.;Platt, T.L.;Webb, R.L.;Head, E.;Murphy, M.P. "Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology." Journal of Alzheimer's disease : JAD 42, 4 (2014): 1221-7. [PubMed Link] | [ Full text ]
  • Martin, S.B.;Dowling, A.L.;Lianekhammy, J.;Lott, I.T.;Doran, E.;Murphy, M.P.;Beckett, T.L.;Schmitt, F.A.;Head, E. "Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease." Journal of Alzheimer's disease : JAD 42, 3 (2014): 767-75. [PubMed Link] | [ Full text ]
  • Head, E. "A canine model of human aging and Alzheimer's disease." Biochimica et biophysica acta 1832, 9 (2013): 1384-9. [PubMed Link] | [ Full text ]
  • Dowling, A.L.;Head, E. "Antioxidants in the canine model of human aging." Biochimica et biophysica acta 1822, 5 (2012): 685-9. [PubMed Link] | [ Full text ]
  • Barone, E.;Mancuso, C.;Di Domenico, F.;Sultana, R.;Murphy, M.P.;Head, E.;Butterfield, D.A. "Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease." Journal of neurochemistry 120, 1 (2012): 135-46. [PubMed Link] | [ Full text ]
  • Holler, C.J.;Webb, R.L.;Laux, A.L.;Beckett, T.L.;Niedowicz, D.M.;Ahmed, R.R.;Liu, Y.;Simmons, C.R.;Dowling, A.L.;Spinelli, A.;Khurgel, M.;Estus, S.;Head, E.;Hersh, L.B.;Murphy, M.P. "BACE2 expression increases in human neurodegenerative disease." The American journal of pathology 180, 1 (2012): 337-50. [PubMed Link] | [ Full text ]
  • Cenini, G.;Dowling, A.L.;Beckett, T.L.;Barone, E.;Mancuso, C.;Murphy, M.P.;Levine H, 3rd;Lott, I.T.;Schmitt, F.A.;Butterfield, D.A.;Head, E. "Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome." Biochimica et biophysica acta 1822, 2 (2012): 130-8. [PubMed Link] | [ Full text ]
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