Daret St Clair, Ph.D.

Research Focus

The primary research focus of this laboratory is in the area of the mitochondrial antioxidant defense system. We cloned the human gene for the primary superoxide removal enzyme in mitochondria, manganese superoxide dismutase (MnSOD), and the initial study has been expanded into several separate but related projects. These projects involve evaluating genetic abnormalities of antioxidant enzymes, the mechanisms regulating gene expression, and the impact these alterations have on the ability of humans to cope with oxidative stress. We made the seminal observation that expression of MnSOD in mitochondria suppresses neoplastic transformation and promotes differentiation of cancer cells, leading to a reduction in their tumorigenicity and metastatic capability. However, contradictory information in the literature based on random detection of MnSOD in cancer cells and human tissues resulted in confusion as to whether and when MnSOD expression is altered in cancer. To directly address this important question, we generated transgenic mice expressing a luciferase reporter gene under the control of human MnSOD promoter/enhancer elements to investigate the changes of MnSOD transcription throughout the development of cancer. The results demonstrate that MnSOD expression was suppressed at a very early stage, but subsequently increased at late stages of skin carcinogenesis. Importantly, the decline in MnSOD expression occurred prior to the development of benign tumors and was concurrent with an increase in glucose utilization. The decline in MnSOD expression in the early stage of cancer was caused by a p53-mediated suppression of MnSOD transcription. However, as the tumor progresses and p53 activity is lost, MnSOD levels rise again, creating conditions in which cancer cells can survive under oxidative stress. The results identify MnSOD as a p53-regulated gene whose expression switches between early and advanced stages of cancer. We further demonstrated that MnSOD serves as a mitochondrial fidelity protein that protects the mitochondrial genome against oxidative stress-induced inactivation. Based on these critical findings, we are testing the hypothesis that defective MnSOD activity signals an adaptive response, leading to activation of a metabolic switch that initiates the Warburg effect, which is an important metabolic change that confers many growth and survival advantages to cancer cells, including a decrease of reactive oxygen species (ROS), a byproduct of mitochondrial energy metabolism.
1. St Clair DK, Wan XS, Oberley TD, Muse KE, St Clair WH: Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase. Mol Carcinog. 6:238-42, 1992.
2. Urano M, Kuroda M, Reynolds R, Oberley TD, St Clair DK: Expression of manganese superoxide dismutase reduces tumor control radiation dose: gene-radiotherapy. Cancer Res. 55:2490-93, 1995.
3. Zhao Y, Xue Y, Oberley TD, Kiningham KK, Lin SM, Yen HC, Majima H, Hines J, St Clair D: Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res. 61:6082-88, 2001.
4. Dhar SK, Tangpong J, Chaiswing L, Oberley TD, and St. Clair DK: Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Cancer Res. 71:8864-95, 2011. PMCID: PMC3206134.
5. Xu,Y, Miriyala S, Fang F., Bakthavatchalu V, Noel T, Schell DM, Wang C, St Clair WH, St Clair DK. Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect. Oncogene. 2014 Nov 3. doi: 10.1038/onc.2014.355.

In another research project, our work has led to a paradigm shift in the thinking about the role of antioxidants in cancer therapy. Using MnSOD transgenic and knockout mice, we have demonstrated the important roles of MnSOD in the regulation of cell proliferation and cell death, which, in turn, modulate subsequent tumor formation. The most important outcome from these results is the knowledge that MnSOD inhibits both apoptosis and proliferation induced by ROS-generating carcinogens when given prior to exposure to carcinogens; when MnSOD mimetic is applied after the peak of apoptosis and before the peak of proliferation, the MnSOD mimetic can inhibit ROS-induced proliferation without suppressing ROS-induced apoptosis. The window between apoptosis and proliferation provides an opportunity to utilize an antioxidant intervention that selectively suppresses cell proliferation without interfering with apoptosis. These findings, coupled to our original finding that excessive ROS play an important role in mediating normal tissue injury caused by established chemotherapeutics, reveal a novel strategy that could be exploited for either developing antioxidant-based cancer prevention or sensitizing cancer cells to radiation- or chemo-based therapies.
1. Yen HC, Oberley TD, Vichitbandha S, Ho YS, St Clair DK: The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest. 98:1253-60, 1996.
2. Zhao, Y., Oberley, T.D., Chaiswing, L., Lin, S-M., Epstein, C.J., Huang, T-T., and St. Clair, D.K. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alteration in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene, 21:3836-846,2002.
3. Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St Clair DK: p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res. 65:3745-50, 2005.
4. Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St Clair DK: p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res. 65:3745-50, 2005.

Generation of ROS is a major mechanism responsible for the therapeutic effect of ionizing radiation and nearly 50% of chemotherapeutic drugs. Currently, these therapeutic strategies are being used to kill cancer cells without the benefit of a rational design that exploits the intrinsic differences in the cellular redox status of normal cells and cancer cells. Cancer cells are usually under higher oxidative stress than normal cells and it is known that an additional increase in prooxidant level can trigger cell death. Thus, therapeutic approaches that use redox active antioxidants that push tumor cells into oxidative stress overload but stimulate adaptive responses in normal cells can be developed to selectively enhance the efficient killing of cancer cells by radiation/chemotherapy. We are developing a novel dual-purpose drug approach that would not only improve the efficacy of cancer therapy but could also improve quality of life for cancer survivors by protecting normal tissue from ROS-generating therapeutics.
1. Xu Y, Josson S, Fang F, Oberley TD, St. Clair DK, Wan SX, Sun Y, Bakthavatchalu V, Muthuswamy R, and St. Clair WH: RelB Enhances Prostate Cancer Growth: Implications for the Role of the NF-kB Alternative Pathway in Tumorigenicity. Cancer Res. 69:3267-71, 2009. PMCID: PMC2756761.
2. Sun Y, St. Clair DK, Xu Y, Crooks PA, and St. Clair WH: A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res. 70:2880-90, 2010. PMCID: PMC2848907.
3. Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, Noel T, Holley AK, Zhao Y, Kiningham KK, St Clair DK, St Clair WH: KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of Parthenolide in Normal and Cancer Cells. Cancer Res. 73:4406-17, 2013. PMCID: PMC3715565.
4. Dong C, Yuan T, Wu Y, Wang Y, Fan T, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St. Clair D, Hung M, Evers BM, Zhou BP: Loss of FBP1 by snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 23: 316-31, 2013. PMCID: PMC3703516.

Over the past several years, we have assembled a team of investigators in a series of studies that move between bench and bedside, leading to a novel model of ROS-induced cognitive and cardiac dysfunction. Our model proposes that, in addition to the direct ROS-mediated mitochondrial injury in cardiac tissue, there is an indirect mechanism for drug-induced injury common to both cardiac and CNS tissues that results from a cytokine-mediated chain of events triggered by Drug-induced oxidative modification of proteins. This team project is based on our initial studies, which demonstrated that oxidative damage precedes nitrative damage in cardiac tissue treated with ROS generating chemotherapeutic drug including Doxorubicin, Dox and that animals deficient in both TNF receptors I and II suffer cardiac injury when exposed to Dox. Using mitochondria arrays and redox proteomics, we identified 4-hydroxynonenal (HNE)-bound mitochondrial proteins, which reveals a systemic effect on energy metabolism after Dox treatment. This team project is designed to identify practice- changing therapy through an integrated program of carefully coordinated mechanistic, intervention, and translational studies with the potential to limit currently devastating tissue toxicities that compromise critical physiological functions. Such advances may significantly improve the lives of cancer survivors.
1. Lien, Y-C., Lin, S-M., Nithipongvanich, R., Oberley, T.D., Noel, T.D., Zhao, Q., Daosukho, C., St. Clair, D.K. TNF receptors deficiency exacerbated adriamycin-induced cardiomyocytes apoptosis: An Insight into Fas connection. Mol. Cancer Therapeutics, 5:261-69,2006.
2. Lien YC, Noel T, Liu H, Stromberg AJ, Chen KC, St Clair DK: Phospholipase C-delta1 is a critical target for tumor necrosis factor receptor-mediated protection against adriamycin-induced cardiac injury. Cancer Res. 66:4329-38, 2006.
3. Aluise J.C., Miriyala C., Noel T., Sultana R., Jungsuwadee P., Taylor T.J., Cai J., Pierce W.M., Vore M, Moscow J.A., St Clair D.K. and D. Allan Butterfield D.A. 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain. Free Radic. Biol. Med. 11:1630-1638, 2011.
4. Zhao, Y., Miriyala, S. Miao, L., Mitov, M., Schnell, D., Dhar, S.K., Cai, J., Klein, J.B., Sultana, R., Butterfield, D.A. , Vore, M., Batinic-Haberle, I.7 Bondada, S., and St. Clair, D.K. Redox Proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after Doxorubicin treatment, Free Radic Biol. Med., 72:55-65, 2014.

Serious long-term therapy-induced impairment among cancer survivors is a currently understudied facet of cancer treatment, but one that is emerging as a critical need given clincial successes with certain cancers and treatment modalities. Our current research direction, based on in-depth understandings from this decades-long focus, into antioxidant defense mechanisms that have intriguing potential to address the challenge of serious post-survival impairment. Our overarching goal is to develop a novel dual-purpose drug approach to be used as a component of combination therapy to 1) improve the efficacy of existing cancer therapeutic protocols and 2) reduce the toxic side effects to normal tissues caused by existing therapeutic strategies. This dual-purpose approach to therapeutics is expected not only to enhance treatment efficacy and thereby increase patient survival but also simultaneously to improve quality of life among cancer survivors.

PubMed Publications: 

  • Wei, X.;Xu, Y.;Xu, F.F.;Chaiswing, L.;Schnell, D.;Noel, T.;Wang, C.;Chen, J.;St Clair, D.K.;St Clair, W.H. "RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells." Cancer research 77, 6 (2017): 1345-1356. [PubMed Link] | [ Full text ]
  • Xu, Y.;Miriyala, S.;Fang, F.;Bakthavatchalu, V.;Noel, T.;Schnell, D.M.;Wang, C.;St Clair, W.H.;St Clair, D.K. "Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect." Oncogene (2017): [PubMed Link] | [ Full text ]
  • Ren, X.;St Clair, D.K.;Butterfield, D.A. "Dysregulation of cytokine mediated chemotherapy induced cognitive impairment." Pharmacological research 117, (2017): 267-273. [PubMed Link] | [ Full text ]
  • Oben, K.Z.;Gachuki, B.W.;Alhakeem, S.S.;McKenna, M.K.;Liang, Y.;St Clair, D.K.;Rangnekar, V.M.;Bondada, S. "Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1)." PloS one 12, 1 (2017): e0169767. [PubMed Link] | [ Full text ]
  • Li, L.;Chen, J.;Xiong, G.;St Clair, D.K.;Xu, W.;Xu, R. "Increased ROS production in non-polarized mammary epithelial cells induces monocyte infiltration in 3D culture." Journal of cell science 130, 1 (2017): 190-202. [PubMed Link] | [ Full text ]
  • Indo, H.P.;Hawkins, C.L.;Nakanishi, I.;Matsumoto, K.I.;Matsui, H.;Suenaga, S.;Davies, M.J.;St Clair, D.K.;Ozawa, T.;Majima, H.J. "Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function." Handbook of experimental pharmacology (2017): [PubMed Link] | [ Full text ]
  • Zhao, Y.;Carroll, D.W.;You, Y.;Chaiswing, L.;Wen, R.;Batinic-Haberle, I.;Bondada, S.;Liang, Y.;St Clair, D.K. "A novel redox regulator, MnTnBuOE-2-PyP<sup>5+</sup>, enhances normal hematopoietic stem/progenitor cell function." Redox biology 12, (2017): 129-138. [PubMed Link] | [ Full text ]
  • Miriyala, S.;Thippakorn, C.;Chaiswing, L.;Xu, Y.;Noel, T.;Tovmasyan, A.;Batinic-Haberle, I.;Vander Kooi, C.W.;Chi, W.;Latif, A.A.;Panchatcharam, M.;Prachayasittikul, V.;Butterfield, D.A.;Vore, M.;Moscow, J.;St Clair, D.K. "Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling." Free radical biology & medicine 91, (2016): 68-80. [PubMed Link] | [ Full text ]
  • Indo, H.P.;Majima, H.J.;Terada, M.;Suenaga, S.;Tomita, K.;Yamada, S.;Higashibata, A.;Ishioka, N.;Kanekura, T.;Nonaka, I.;Hawkins, C.L.;Davies, M.J.;Clair, D.K.;Mukai, C. "Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space." Scientific reports 6, (2016): 39015. [PubMed Link] | [ Full text ]
  • Carroll, D.;Howard, D.;Zhu, H.;Paumi, C.M.;Vore, M.;Bondada, S.;Liang, Y.;Wang, C.;St Clair, D.K. "Simultaneous quantitation of oxidized and reduced glutathione via LC-MS/MS: An insight into the redox state of hematopoietic stem cells." Free radical biology & medicine 97, (2016): 85-94. [PubMed Link] | [ Full text ]
  • Majima, H.J.;Indo, H.P.;Nakanishi, I.;Suenaga, S.;Matsumoto, K.;Matsui, H.;Minamiyama, Y.;Ichikawa, H.;Yen, H.C.;Hawkins, C.L.;Davies, M.J.;Ozawa, T.;St Clair, D.K. "Chasing great paths of Helmut Sies "Oxidative Stress"." Archives of biochemistry and biophysics 595, (2016): 54-60. [PubMed Link] | [ Full text ]
  • Kinugasa, H.;Whelan, K.A.;Tanaka, K.;Natsuizaka, M.;Long, A.;Guo, A.;Chang, S.;Kagawa, S.;Srinivasan, S.;Guha, M.;Yamamoto, K.;St Clair, D.K.;Avadhani, N.G.;Diehl, J.A.;Nakagawa, H. "Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression." Oncogene 34, 41 (2015): 5229-39. [PubMed Link] | [ Full text ]
  • Keeney, J.T.;Miriyala, S.;Noel, T.;Moscow, J.A.;St Clair, D.K.;Butterfield, D.A. "Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy." Cancer letters 367, 2 (2015): 157-61. [PubMed Link] | [ Full text ]
  • Barone, E.;Cenini, G.;Di Domenico, F.;Noel, T.;Wang, C.;Perluigi, M.;St Clair, D.K.;Butterfield, D.A. "Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53." Journal of neuroscience research 93, 11 (2015): 1728-39. [PubMed Link] | [ Full text ]
  • Miriyala, S.;Chandra, M.;Maxey, B.;Day, A.;St Clair, D.K.;Panchatcharam, M. "Arjunolic acid ameliorates reactive oxygen species via inhibition of p47(phox)-serine phosphorylation and mitochondrial dysfunction." The international journal of biochemistry & cell biology 68, (2015): 70-7. [PubMed Link] | [ Full text ]
  • Indo, H.P.;Matsui, H.;Chen, J.;Zhu, H.;Hawkins, C.L.;Davies, M.J.;Yarana, C.;St Clair, D.K.;Majima, H.J. "Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion." Journal of clinical biochemistry and nutrition 57, 1 (2015): 13-20. [PubMed Link] | [ Full text ]
  • Indo, H.P.;Yen, H.C.;Nakanishi, I.;Matsumoto, K.;Tamura, M.;Nagano, Y.;Matsui, H.;Gusev, O.;Cornette, R.;Okuda, T.;Minamiyama, Y.;Ichikawa, H.;Suenaga, S.;Oki, M.;Sato, T.;Ozawa, T.;Clair, D.K.;Majima, H.J. "A mitochondrial superoxide theory for oxidative stress diseases and aging." Journal of clinical biochemistry and nutrition 56, 1 (2015): 1-7. [PubMed Link] | [ Full text ]
  • Xu, Y.;Miriyala, S.;Fang, F.;Bakthavatchalu, V.;Noel, T.;Schell, D.M.;Wang, C.;St Clair, W.H.;St Clair, D.K. "Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect." Oncogene 34, 32 (2015): 4229-37. [PubMed Link] | [ Full text ]
  • Holley, A.K.;Xu, Y.;Noel, T.;Bakthavatchalu, V.;Batinic-Haberle, I.;St Clair, D.K. "Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin." Antioxidants & redox signaling 20, 15 (2014): 2347-60. [PubMed Link] | [ Full text ]
  • Breckwoldt, M.O.;Pfister, F.M.;Bradley, P.M.;Marinković, P.;Williams, P.R.;Brill, M.S.;Plomer, B.;Schmalz, A.;St Clair, D.K.;Naumann, R.;Griesbeck, O.;Schwarzländer, M.;Godinho, L.;Bareyre, F.M.;Dick, T.P.;Kerschensteiner, M.;Misgeld, T. "Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo." Nature medicine 20, 5 (2014): 555-60. [PubMed Link] | [ Full text ]
  • Miao, L.;Holley, A.K.;Zhao, Y.;St Clair, W.H.;St Clair, D.K. "Redox-mediated and ionizing-radiation-induced inflammatory mediators in prostate cancer development and treatment." Antioxidants & redox signaling 20, 9 (2014): 1481-500. [PubMed Link] | [ Full text ]
  • Zhao, Y.;Miriyala, S.;Miao, L.;Mitov, M.;Schnell, D.;Dhar, S.K.;Cai, J.;Klein, J.B.;Sultana, R.;Butterfield, D.A.;Vore, M.;Batinic-Haberle, I.;Bondada, S.;St Clair, D.K. "Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment." Free radical biology & medicine 72, (2014): 55-65. [PubMed Link] | [ Full text ]
  • Liu, S.;Miriyala, S.;Keaton, M.A.;Jordan, C.T.;Wiedl, C.;Clair, D.K.;Moscow, J.A. "Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells." PloS one 9, 1 (2014): e85702. [PubMed Link] | [ Full text ]
  • Cole, M.P.;Tangpong, J.;Oberley, T.D.;Chaiswing, L.;Kiningham, K.K.;St Clair, D.K. "Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice." PloS one 9, 2 (2014): e89251. [PubMed Link] | [ Full text ]
  • Holley, A.K.;Miao, L.;St Clair, D.K.;St Clair, W.H. "Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases." Antioxidants & redox signaling 20, 10 (2014): 1567-89. [PubMed Link] | [ Full text ]
  • Dhar, S.K.;Zhang, J.;Gal, J.;Xu, Y.;Miao, L.;Lynn, B.C.;Zhu, H.;Kasarskis, E.J.;St Clair, D.K. "FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription." Antioxidants & redox signaling 20, 10 (2014): 1550-66. [PubMed Link] | [ Full text ]
  • Holley, A.K.;Dhar, S.K.;St Clair, D.K. "Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?" Mitochondrion 13, 3 (2013): 170-88. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;Miriyala, S.;Crooks, P.A.;Oberley, T.D.;Chaiswing, L.;Noel, T.;Holley, A.K.;Zhao, Y.;Kiningham, K.K.;Clair, D.K.;Clair, W.H. "KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells." Cancer research 73, 14 (2013): 4406-17. [PubMed Link] | [ Full text ]
  • Ibrahim, W.H.;Habib, H.M.;Kamal, H.;St Clair, D.K.;Chow, C.K. "Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria." Free radical biology & medicine 65, (2013): 143-9. [PubMed Link] | [ Full text ]
  • Sun, Y.;Holley, A.K.;St Clair, D.K. "p53 regulation of energy metabolism and mitochondria regulation of p53 in cancer cells: an insight into the role of manganese superoxide dismutase." Current pharmaceutical biotechnology 14, 3 (2013): 261-73. [PubMed Link] | [ Full text ]
  • Barone, E.;Cenini, G.;Sultana, R.;Di Domenico, F.;Fiorini, A.;Perluigi, M.;Noel, T.;Wang, C.;Mancuso, C.;St Clair, D.K.;Butterfield, D.A. "Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B." Antioxidants & redox signaling 16, 12 (2012): 1407-20. [PubMed Link] | [ Full text ]
  • Dhar, S.K.;St Clair, D.K. "Manganese superoxide dismutase regulation and cancer." Free radical biology & medicine 52, 11-12 (2012): 2209-22. [PubMed Link] | [ Full text ]
  • Liu, S.;Bae, Y.;Leggas, M.;Daily, A.;Bhatnagar, S.;Miriyala, S.;St Clair, D.K.;Moscow, J.A. "Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme." The Journal of pharmacology and experimental therapeutics 341, 3 (2012): 775-83. [PubMed Link] | [ Full text ]
  • Batinic-Haberle, I.;Spasojevic, I.;Tse, H.M.;Tovmasyan, A.;Rajic, Z.;St Clair, D.K.;Vujaskovic, Z.;Dewhirst, M.W.;Piganelli, J.D. "Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities." Amino acids 42, 1 (2012): 95-113. [PubMed Link] | [ Full text ]
  • Holley, A.K.;Dhar, S.K.;Xu, Y.;St Clair, D.K. "Manganese superoxide dismutase: beyond life and death." Amino acids 42, 1 (2012): 139-58. [PubMed Link] | [ Full text ]
  • Evans, A.R.;Miriyala, S.;St Clair, D.K.;Butterfield, D.A.;Robinson, R.A. "Global effects of adriamycin treatment on mouse splenic protein levels." Journal of proteome research 11, 2 (2012): 1054-64. [PubMed Link] | [ Full text ]
  • Indo, H.P.;Inanami, O.;Koumura, T.;Suenaga, S.;Yen, H.C.;Kakinuma, S.;Matsumoto, K.;Nakanishi, I.;St Clair, W.;St Clair, D.K.;Matsui, H.;Cornette, R.;Gusev, O.;Okuda, T.;Nakagawa, Y.;Ozawa, T.;Majima, H.J. "Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE." Free radical research 46, 8 (2012): 1029-43. [PubMed Link] | [ Full text ]
  • Duncan, M.J.;Smith, J.T.;Franklin, K.M.;Beckett, T.L.;Murphy, M.P.;St Clair, D.K.;Donohue, K.D.;Striz, M.;O'Hara, B.F. "Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease." Experimental neurology 236, 2 (2012): 249-58. [PubMed Link] | [ Full text ]
  • Bakthavatchalu, V.;Dey, S.;Xu, Y.;Noel, T.;Jungsuwadee, P.;Holley, A.K.;Dhar, S.K.;Batinic-Haberle, I.;St Clair, D.K. "Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation." Oncogene 31, 17 (2012): 2129-39. [PubMed Link] | [ Full text ]
  • Jungsuwadee, P.;Zhao, T.;Stolarczyk, E.I.;Paumi, C.M.;Butterfield, D.A.;St Clair, D.K.;Vore, M. "The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal." Pharmacogenetics and genomics 22, 4 (2012): 273-84. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;St Clair, D.K.;St Clair, W.H. "Inverse relationship between PSA and IL-8 in prostate cancer: an insight into a NF-κB-mediated mechanism." PloS one 7, 3 (2012): e32905. [PubMed Link] | [ Full text ]
  • Sultana, R.;Robinson, R.A.;Di Domenico, F.;Abdul, H.M.;St Clair, D.K.;Markesbery, W.R.;Cai, J.;Pierce, W.M.;Butterfield, D.A. "Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age." Journal of proteomics 74, 11 (2011): 2430-40. [PubMed Link] | [ Full text ]
  • Dhar, S.K.;Tangpong, J.;Chaiswing, L.;Oberley, T.D.;St Clair, D.K. "Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages." Cancer research 71, 21 (2011): 6684-95. [PubMed Link] | [ Full text ]
  • Gilliam, L.A.;St Clair, D.K. "Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress." Antioxidants & redox signaling 15, 9 (2011): 2543-63. [PubMed Link] | [ Full text ]
  • Robinson, R.A.;Joshi, G.;Huang, Q.;Sultana, R.;Baker, A.S.;Cai, J.;Pierce, W.;St Clair, D.K.;Markesbery, W.R.;Butterfield, D.A. "Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild..." Proteomics 11, 21 (2011): 4243-56. [PubMed Link] | [ Full text ]
  • Velez, J.M.;Miriyala, S.;Nithipongvanitch, R.;Noel, T.;Plabplueng, C.D.;Oberley, T.;Jungsuwadee, P.;Van Remmen, H.;Vore, M.;St Clair, D.K. "p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury." PloS one 6, 3 (2011): e18005. [PubMed Link] | [ Full text ]
  • Aluise, C.D.;Miriyala, S.;Noel, T.;Sultana, R.;Jungsuwadee, P.;Taylor, T.J.;Cai, J.;Pierce, W.M.;Vore, M.;Moscow, J.A.;St Clair, D.K.;Butterfield, D.A. "2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain." Free radical biology & medicine 50, 11 (2011): 1630-8. [PubMed Link] | [ Full text ]
  • Tangpong, J.;Miriyala, S.;Noel, T.;Sinthupibulyakit, C.;Jungsuwadee, P.;St Clair, D.K. "Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia mangostana." Neuroscience 175, (2011): 292-9. [PubMed Link] | [ Full text ]
  • Miriyala, S.;Holley, A.K.;St Clair, D.K. "Mitochondrial superoxide dismutase--signals of distinction." Anti-cancer agents in medicinal chemistry 11, 2 (2011): 181-90. [PubMed Link] | [ Full text ]
  • Holley, A.K.;Bakthavatchalu, V.;Velez-Roman, J.M.;St Clair, D.K. "Manganese superoxide dismutase: guardian of the powerhouse." International journal of molecular sciences 12, 10 (2011): 7114-62. [PubMed Link] | [ Full text ]
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  • Sultana, R.;Di Domenico, F.;Tseng, M.;Cai, J.;Noel, T.;Chelvarajan, R.L.;Pierce, W.D.;Cini, C.;Bondada, S.;St Clair, D.K.;Butterfield, D.A. "Doxorubicin-induced thymus senescence." Journal of proteome research 9, 12 (2010): 6232-41. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;Zhang, J.;Josson, S.;St Clair, W.H.;St Clair, D.K. "miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes." PloS one 5, 12 (2010): e14356. [PubMed Link] | [ Full text ]
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  • Sun, Y.;St Clair, D.K.;Xu, Y.;Crooks, P.A.;St Clair, W.H. "A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells." Cancer research 70, 7 (2010): 2880-90. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;Sun, Y.;St Clair, D.K.;St Clair, W.H. "RelB-dependent differential radiosensitization effect of STI571 on prostate cancer cells." Molecular cancer therapeutics 9, 4 (2010): 803-12. [PubMed Link] | [ Full text ]
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  • Xu, Y.;Josson, S.;Fang, F.;Oberley, T.D.;St Clair, D.K.;Wan, X.S.;Sun, Y.;Bakthavatchalu, V.;Muthuswamy, A.;St Clair, W.H. "RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity." Cancer research 69, 8 (2009): 3267-71. [PubMed Link] | [ Full text ]
  • Spasojević, I.;Chen, Y.;Noel, T.J.;Fan, P.;Zhang, L.;Rebouças, J.S.;St Clair, D.K.;Batinić-Haberle, I. "Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice." Free radical biology & medicine 45, 7 (2008): 943-9. [PubMed Link] | [ Full text ]
  • Dey, S.;Bakthavatchalu, V.;Tseng, M.T.;Wu, P.;Florence, R.L.;Grulke, E.A.;Yokel, R.A.;Dhar, S.K.;Yang, H.S.;Chen, Y.;St Clair, D.K. "Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells." Carcinogenesis 29, 10 (2008): 1920-9. [PubMed Link] | [ Full text ]
  • García-Cazarín, M.L.;Smith, J.L.;Clair, D.K.;Piascik, M.T. "The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism." Molecular pharmacology 74, 4 (2008): 1000-7. [PubMed Link] | [ Full text ]
  • Abdul, H.M.;Sultana, R.;St Clair, D.K.;Markesbery, W.R.;Butterfield, D.A. "Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age." Free radical biology & medicine 45, 10 (2008): 1420-5. [PubMed Link] | [ Full text ]
  • Tangpong, J.;Sompol, P.;Vore, M.;St Clair, W.;Butterfield, D.A.;St Clair, D.K. "Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells." Neuroscience 151, 2 (2008): 622-9. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;Dhar, S.K.;Bosch, A.;St Clair, W.H.;Kasarskis, E.J.;St Clair, D.K. "Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells." Molecular cancer research : MCR 6, 12 (2008): 1881-93. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;St Clair, D.K.;Sompol, P.;Josson, S.;St Clair, W.H. "SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation." Molecular cancer therapeutics 7, 8 (2008): 2367-76. [PubMed Link] | [ Full text ]
  • Sompol, P.;Ittarat, W.;Tangpong, J.;Chen, Y.;Doubinskaia, I.;Batinic-Haberle, I.;Abdul, H.M.;Butterfield, D.A.;St Clair, D.K. "A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury." Neuroscience 153, 1 (2008): 120-30. [PubMed Link] | [ Full text ]
  • Liu, J.;St Clair, D.K.;Gu, X.;Zhao, Y. "Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion." FEBS letters 582, 9 (2008): 1319-24. [PubMed Link] | [ Full text ]
  • Liu, B.;Chen, Y.;St Clair, D.K. "ROS and p53: a versatile partnership." Free radical biology & medicine 44, 8 (2008): 1529-35. [PubMed Link] | [ Full text ]
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  • Murphy, M.P.;Beckett, T.L.;Ding, Q.;Patel, E.;Markesbery, W.R.;St Clair, D.K.;Levine H, 3rd;Keller, J.N. "Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice." Neurobiology of disease 27, 3 (2007): 301-11. [PubMed Link] | [ Full text ]
  • Daosukho, C.;Chen, Y.;Noel, T.;Sompol, P.;Nithipongvanitch, R.;Velez, J.M.;Oberley, T.D.;St Clair, D.K. "Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury." Free radical biology & medicine 42, 12 (2007): 1818-25. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;Dhar, S.K.;St Clair, W.H.;Kasarskis, E.J.;St Clair, D.K. "The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene." The Journal of biological chemistry 282, 22 (2007): 15981-94. [PubMed Link] | [ Full text ]
  • Chen, Y.;Jungsuwadee, P.;Vore, M.;Butterfield, D.A.;St Clair, D.K. "Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues." Molecular interventions 7, 3 (2007): 147-56. [PubMed Link] |
  • Nithipongvanitch, R.;Ittarat, W.;Velez, J.M.;Zhao, R.;St Clair, D.K.;Oberley, T.D. "Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 55, 6 (2007): 629-39. [PubMed Link] | [ Full text ]
  • Xu, Y.;Fang, F.;St Clair, D.K.;Josson, S.;Sompol, P.;Spasojevic, I.;St Clair, W.H. "Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1alpha,25-dihydroxyvitamin D(3) in prostate cancer cells." Molecular cancer therapeutics 6, 7 (2007): 2048-56. [PubMed Link] | [ Full text ]
  • Nithipongvanitch, R.;Ittarat, W.;Cole, M.P.;Tangpong, J.;Clair, D.K.;Oberley, T.D. "Mitochondrial and nuclear p53 localization in cardiomyocytes: redox modulation by doxorubicin (Adriamycin)?" Antioxidants & redox signaling 9, 7 (2007): 1001-8. [PubMed Link] | [ Full text ]
  • Tangpong, J.;Cole, M.P.;Sultana, R.;Estus, S.;Vore, M.;St Clair, W.;Ratanachaiyavong, S.;St Clair, D.K.;Butterfield, D.A. "Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain." Journal of neurochemistry 100, 1 (2007): 191-201. [PubMed Link] | [ Full text ]
  • Joshi, G.;Hardas, S.;Sultana, R.;St Clair, D.K.;Vore, M.;Butterfield, D.A. "Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain." Journal of neuroscience research 85, 3 (2007): 497-503. [PubMed Link] | [ Full text ]
  • Dhar, S.K.;Xu, Y.;Noel, T.;St Clair, D.K. "Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: the negative role of p50." Carcinogenesis 28, 12 (2007): 2605-13. [PubMed Link] | [ Full text ]
  • Spasojević, I.;Chen, Y.;Noel, T.J.;Yu, Y.;Cole, M.P.;Zhang, L.;Zhao, Y.;St Clair, D.K.;Batinić-Haberle, I. "Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria." Free radical biology & medicine 42, 8 (2007): 1193-200. [PubMed Link] | [ Full text ]
  • Chen, Y.;Daosukho, C.;Opii, W.O.;Turner, D.M.;Pierce, W.M.;Klein, J.B.;Vore, M.;Butterfield, D.A.;St Clair, D.K. "Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice." Free radical biology & medicine 41, 9 (2006): 1470-7. [PubMed Link] | [ Full text ]
  • Jungsuwadee, P.;Cole, M.P.;Sultana, R.;Joshi, G.;Tangpong, J.;Butterfield, D.A.;St Clair, D.K.;Vore, M. "Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice." Molecular cancer therapeutics 5, 11 (2006): 2851-60. [PubMed Link] | [ Full text ]
  • Anantharaman, M.;Tangpong, J.;Keller, J.N.;Murphy, M.P.;Markesbery, W.R.;Kiningham, K.K.;St Clair, D.K. "Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease." The American journal of pathology 168, 5 (2006): 1608-18. [PubMed Link] | [ Full text ]
  • Josson, S.;Xu, Y.;Fang, F.;Dhar, S.K.;St Clair, D.K.;St Clair, W.H. "RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells." Oncogene 25, 10 (2006): 1554-9. [PubMed Link] | [ Full text ]
  • Mohmmad Abdul, H.;Sultana, R.;Keller, J.N.;St Clair, D.K.;Markesbery, W.R.;Butterfield, D.A. "Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications..." Journal of neurochemistry 96, 5 (2006): 1322-35. [PubMed Link] | [ Full text ]
  • Tangpong, J.;Cole, M.P.;Sultana, R.;Joshi, G.;Estus, S.;Vore, M.;St Clair, W.;Ratanachaiyavong, S.;St Clair, D.K.;Butterfield, D.A. "Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity." Neurobiology of disease 23, 1 (2006): 127-39. [PubMed Link] | [ Full text ]
  • Cole, M.P.;Chaiswing, L.;Oberley, T.D.;Edelmann, S.E.;Piascik, M.T.;Lin, S.M.;Kiningham, K.K.;St Clair, D.K. "The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity." Cardiovascular research 69, 1 (2006): 186-97. [PubMed Link] | [ Full text ]
  • Lien, Y.C.;Daosukho, C.;St Clair, D.K. "TNF receptor deficiency reveals a translational control mechanism for adriamycin-induced Fas expression in cardiac tissues." Cytokine 33, 4 (2006): 226-30. [PubMed Link] | [ Full text ]
  • Lien, Y.C.;Lin, S.M.;Nithipongvanitch, R.;Oberley, T.D.;Noel, T.;Zhao, Q.;Daosukho, C.;St Clair, D.K. "Tumor necrosis factor receptor deficiency exacerbated Adriamycin-induced cardiomyocytes apoptosis: an insight into the Fas connection." Molecular cancer therapeutics 5, 2 (2006): 261-9. [PubMed Link] | [ Full text ]
  • Dhar, S.K.;Xu, Y.;Chen, Y.;St Clair, D.K. "Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression." The Journal of biological chemistry 281, 31 (2006): 21698-709. [PubMed Link] | [ Full text ]
  • Zhao, Y.;Chaiswing, L.;Bakthavatchalu, V.;Oberley, T.D.;St Clair, D.K. "Ras mutation promotes p53 activation and apoptosis of skin keratinocytes." Carcinogenesis 27, 8 (2006): 1692-8. [PubMed Link] | [ Full text ]
  • Lien, Y.C.;Noel, T.;Liu, H.;Stromberg, A.J.;Chen, K.C.;St Clair, D.K. "Phospholipase C-delta1 is a critical target for tumor necrosis factor receptor-mediated protection against adriamycin-induced cardiac injury." Cancer research 66, 8 (2006): 4329-38. [PubMed Link] | [ Full text ]
  • Lien, Y.C.;Lin, S.M.;Nithipongvanich, R.;Oberley, T.D.;Noel, T.D.;Zhao, Q.;Daosukho, C.;St. Clair, D.K. "TNF receptors deficiency exacerbated adriamycin-induced cardiomyocytes apoptosis: An Insight into Fas connection" Mol. Cancer Therapeutics (2006):
  • Zhao, Y.;Wang, L.M.;Chaiswing, L.;Yen, H.C.;Oberley, T.D.;Lien, Y.C.;Lin, S.M.;Mattson, M.P.;St. Clair, D.K. "Tamoxifen protects acute TNF α-induced cardiac injury via improving mitochondrial functions" Free Radic. Biol. Med. (2006):
  • Butterfield, D.A.;Poon, F.;St. Clair, D.K.;Keller, J.N.;Pierce, W.M.;Klien, J.B.;Markesbery, W.R. "Redox proteomics identification of modified hippocampal proteins in mild cognitive impairment: Insight into the development of Alzheimer’s disease" Neurobiol. Dis. (2006):
  • Sompol, P.;Xu, Y.;Ittarat, W.;Daosukho, C.;St. Clair, D.K. "NF-kB associated MnSOD induction protects against beta-Amyloid-induced neuronal apoptosis" J. Mol. Neurosci. (2006):
  • Joshi, G.;Sultana, R.;Tangpong, J.;Cole, M.P.;St Clair, D.K.;Vore, M.;Estus, S.;Butterfield, D.A. "Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: insight into chemobrain." Free radical research 39, 11 (2005): 1147-54. [PubMed Link] | [ Full text ]
  • Daosukho, C.;Ittarat, W.;Lin, S.M.;Sawyer, D.B.;Kiningham, K.;Lien, Y.C.;St Clair, D.K. "Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of tamoxifen (TAM)." Journal of molecular and cellular cardiology 39, 5 (2005): 792-803. [PubMed Link] | [ Full text ]
  • Zhao, Y.;Chaiswing, L.;Velez, J.M.;Batinic-Haberle, I.;Colburn, N.H.;Oberley, T.D.;St Clair, D.K. "p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase." Cancer research 65, 9 (2005): 3745-50. [PubMed Link] | [ Full text ]
  • Porntadavity, S.;Nath, A.;Prachayasittikul, V.;Cota-Gomez, A.;Flores, S.C.;St Clair, D.K. "Different roles of Sp family members in HIV-1 Tat-mediated manganese superoxide dismutase suppression in hepatocellular carcinoma cells." DNA and cell biology 24, 5 (2005): 299-310. [PubMed Link] | [ Full text ]
  • Chaiswing, L.;Cole, M.P.;Ittarat, W.;Szweda, L.I.;St Clair, D.K.;Oberley, T.D. "Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity." Molecular cancer therapeutics 4, 7 (2005): 1056-64. [PubMed Link] | [ Full text ]
  • Porntadavity, S.;Nath, A.;Prachayasitikul, V.;Cota-Gomez, A.;Flores, S.C.;St. Clair, D.K. "Differential roles of Sp family members in HIV-1 tat-mediated superoxide dismutase suppression in hepatocellular cells" DNA and Cell Biology (2005):
  • Wang, Y.;Kuroda, M.;Gao, X.;Asaumi, J.;Shibuya, K.;Kawasaki, S.;Akaki, S.;St. Clair, D.K.;Hiraki, Y.;Kanazawa, S. "S. Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS2FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line" Int. J. Oncol. (2005):
  • St. Clair, D.K.;Zhao, Y.;Chaiswing, L.;Oberley, T. "T. Modulation of skin tumorigenesis by SOD" Biomedicine & Pharmacotherapy (2005):
  • Zhao, Y.;Chaiswing, L.;Oberley, T.D.;Batinic-Baherle, I.;St. Clair, W.H.;Epstein, C.J.;St. Clair, D.K. "A mechanism based antioxidant approach for the reduction of skin carcinogenesis" Cancer Res. (2005):
  • Chaiswing, L.;Cole, M.P.;St. Clair, D.K.;Ittarrat, W.;Szweda, L.I.;Oberley, T.D. "Early Mitochondrial oxidative/nitrative damage in Adriamycin-induced cardiac injury" Mol. Cancer Therapeutics (2005):
  • Chaiswing, L.;Cole, M.P.;St Clair, D.K.;Ittarat, W.;Szweda, L.I.;Oberley, T.D. "Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury." Toxicologic pathology 32, 5 (2004): 536-47. [PubMed Link] | [ Full text ]
  • Marecki, J.C.;Cota-Gomez, A.;Vaitaitis, G.M.;Honda, J.R.;Porntadavity, S.;St Clair, D.K.;Flores, S.C. "HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity." Free radical biology & medicine 37, 6 (2004): 869-80. [PubMed Link] |
  • Oberley, T.D.;Xue, Y.;Zhao, Y.;Kiningham, K.;Szweda, L.I.;St Clair, D.K. "In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model." Antioxidants & redox signaling 6, 3 (2004): 537-48. [PubMed Link] | [ Full text ]
  • Hirai, F.;Motoori, S.;Kakinuma, S.;Tomita, K.;Indo, H.P.;Kato, H.;Yamaguchi, T.;Yen, H.C.;St Clair, D.K.;Nagano, T.;Ozawa, T.;Saisho, H.;Majima, H.J. "Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in a human pancreatic cancer cell line, KP4." Antioxidants & redox signaling 6, 3 (2004): 523-35. [PubMed Link] | [ Full text ]
  • Dhar, S.K.;Lynn, B.C.;Daosukho, C.;St Clair, D.K. "Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene." The Journal of biological chemistry 279, 27 (2004): 28209-19. [PubMed Link] | [ Full text ]
  • Kiningham, K.K.;Daosukho, C.;St Clair, D.K. "IkappaBalpha (inhibitory kappaBalpha) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression." The Biochemical journal 384, Pt 3 (2004): 543-9. [PubMed Link] | [ Full text ]
  • St. Clair, D.K. "Manganese superoxide dismutase; Genetic variation and regulation" J. of Nutr. (2004):
  • Kiningham, K.K.;Daosukho, C.;St. Clair, D.K. "IkB-a identified as labile repressor of manganese superoxide dismutase (MnSOD) expression" Biochem. J. (2004):
  • Zhao, Y.;St Clair, D.K. "Detection of the content and activity of the transcription factor AP-1 in a multistage skin carcinogenesis model." Methods in molecular biology (Clifton, N.J.) 218, (2003): 177-84. [PubMed Link] |
  • St. Clair, D.K.;Kasarskis, E.J. "Genetic polymorphism of the human manganese superoxide dismutase: What difference does it make? " Pharmacogenetics (2003):
  • Daosukho, C.;Kiningham, K.;Kasarskis, E.J.;Ittarat, W.;St Clair, D.K. "Tamoxifen enhancement of TNF-alpha induced MnSOD expression: modulation of NF-kappaB dimerization." Oncogene 21, 22 (2002): 3603-10. [PubMed Link] | [ Full text ]
  • Xu, Y.;Porntadavity, S.;St Clair, D.K. "Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2)." The Biochemical journal 362, Pt 2 (2002): 401-12. [PubMed Link] | [ Full text ]
  • Chow, C.K.;Yen, H.C.;Ibrahim, W.;St Clair, D.K. "Manganese superoxide dismutase transgenic mice: characteristics and implications." Methods in enzymology 353, (2002): 398-409. [PubMed Link] |
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  • Cole, M.P.;Chaiswing, L.;Oberley, T.D.;Kiningham, K.K.;St. Clair, D.K. "Superoxide, superoxide dismutases and cardiovascular dysfunction" Mechanisms of Cardiovascular Aging. Advances in Cell Aging and Gerontology (2002):
  • Zhao, Y.;Oberley, T.D.;Chaiswing, L.;Lin, S.M.;Epstein, C.J.;Huang, T.T.;St. Clair, D.K. "Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alteration in AP-1 and p53-mediated pathways in a skin cancer model" Oncogene (2002):
  • Zhao, Y.;Kiningham, K.K.;Lin, S.M.;St Clair, D.K. "Overexpression of MnSOD protects murine fibrosarcoma cells (FSa-II) from apoptosis and promotes a differentiation program upon treatment with 5-azacytidine: involvement of MAPK and NFkappaB pathways." Antioxidants & redox signaling 3, 3 (2001): 375-86. [PubMed Link] | [ Full text ]
  • Kiningham, K.K.;Xu, Y.;Daosukho, C.;Popova, B.;St Clair, D.K. "Nuclear factor kappaB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2." The Biochemical journal 353, Pt 1 (2001): 147-156. [PubMed Link] | [ Full text ]
  • Porntadavity, S.;Xu, Y.;Kiningham, K.;Rangnekar, V.M.;Prachayasittikul, V.;St Clair, D.K. "TPA-activated transcription of the human MnSOD gene: role of transcription factors Sp-1 and Egr-1." DNA and cell biology 20, 8 (2001): 473-81. [PubMed Link] | [ Full text ]
  • St. Clair, D.K. "Manganese superoxide dismutase: Roles in Cancer Therapy" Antioxidants and Free Radicals in Health and Disease (2001):
  • Kiningham, K.K.;Xu, Y.;Daosukho, C.;Popova, B.;St. Clair, D.K. "NF-kB-dependent mechanisms coordinate the synergistic effect of TPA and cytokines on SOD2 induction" Biochem. J. (2001):
  • Zhao, Y.;Kiningham, K.K.;Lin, S.M.;St. Clair, D.K. "Overexpression of MnSOD prevents murine fibrosarcoma (FsaII) cells from apoptosis and promotes a differentiation program upon treatment with 5-azacytidine: Involvement of MARK and NF-kB pathways" Antioxidants & Redox Signaling (2001):
  • Zhao, Y.;Xue, Y.;Oberley, T.D.;Kiningham, K.K.;Lin, S.M.;Yen, H.C.;Majima, H.;Hines, J.;St. Clair, D.K. "Overexpression of MnSOD suppresses tumor formation by modulation of AP-1 signaling in a multistage skin carcinogenesis model" Cancer Res. (2001):
  • Kuroda, M.;Himei, K.;St Clair, D.K.;Urano, M.;Yoshino, T.;Akagi, T.;Asaumi, J.;Akaki, S.;Takeda, Y.;Kanazawa, S.;Hiraki, Y. "Overexpression of manganese superoxide dismutase gene suppresses spontaneous apoptosis without a resultant alteration in in vivo growth of the mouse fibrosarcoma, FSa-II." Anticancer research 20, 1A (2000): 7-10. [PubMed Link] |
  • Ibrahim, W.;Lee, U.S.;Yen, H.C.;St Clair, D.K.;Chow, C.K. "Antioxidant and oxidative status in tissues of manganese superoxide dismutase transgenic mice." Free radical biology & medicine 28, 3 (2000): 397-402. [PubMed Link] | [ Full text ]
  • Kasarskis, E.;St. Clair, D.K. "Genetic abnormalities in Amyotrophic Lateral Sclerosis" Eds. Advances in Cell Aging and Gerontology (2000):
  • Maragos, W.F.;Jakel, R.;Chesnut, D.;Pocernich, C.B.;Butterfield, D.A.;St. Clair, D.K.;Cass, W.A. "Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase" Brain Res. (2000):
  • Xu, Y.;Kiningham, K.K.;Devalaraja, M.N.;Yeh, C.C.;Majima, H.;Kasarskis, E.J.;St Clair, D.K. "An intronic NF-kappaB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-alpha and interleukin-1beta." DNA and cell biology 18, 9 (1999): 709-22. [PubMed Link] | [ Full text ]
  • Kiningham, K.K.;Oberley, T.D.;Lin, S.;Mattingly, C.A.;St Clair, D.K. "Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 13, 12 (1999): 1601-10. [PubMed Link] | [ Full text ]
  • Xu, Y.;Krishnan, A.;Wan, X.S.;Majima, H.;Yeh, C.C.;Ludewig, G.;Kasarskis, E.J.;St Clair, D.K. "Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells." Oncogene 18, 1 (1999): 93-102. [PubMed Link] | [ Full text ]
  • Yen, H.C.;Oberley, T.D.;Gairola, C.G.;Szweda, L.I.;St Clair, D.K. "Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice." Archives of biochemistry and biophysics 362, 1 (1999): 59-66. [PubMed Link] | [ Full text ]
  • Sullivan, P.G.;Bruce-Keller, A.J.;Rabchevsky, A.G.;Christakos, S.;Clair, D.K.;Mattson, M.P.;Scheff, S.W. "Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury." The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 15 (1999): 6248-56. [PubMed Link] | [ Full text ]
  • Xu, Y.;Kiningham, K.K.;Devalaraja, M.N.;Yeh, C.C.;Majima, H.;Kasarskis, E.D.;St. Clair, D.K. "An intronic NF-kB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-a and interleukin-1b" DNA and Cell Biology (1999):
  • St. Clair, D.K.;Xu, Y.;Krishnan, A.;Wan, X.S.;Kasarskis, E.J. "Mutations in MnSOD gene in Amyotrophic Lateral Sclerosis in Superoxide Dismutases" Recent Advances and Clinical Applications (1999): 95-99.
  • Yeh, C.C.;Wan, X.S.;St Clair, D.K. "Transcriptional regulation of the 5' proximal promoter of the human manganese superoxide dismutase gene." DNA and cell biology 17, 11 (1998): 921-30. [PubMed Link] | [ Full text ]
  • Keller, J.N.;Kindy, M.S.;Holtsberg, F.W.;St Clair, D.K.;Yen, H.C.;Germeyer, A.;Steiner, S.M.;Bruce-Keller, A.J.;Hutchins, J.B.;Mattson, M.P. "Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction." The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 2 (1998): 687-97. [PubMed Link] | [ Full text ]
  • Tomblyn, M.;Kasarskis, E.J.;Xu, Y.;St Clair, D.K. "Distribution of MnSOD polymorphisms in sporadic ALS patients." Journal of molecular neuroscience : MN 10, 1 (1998): 65-6. [PubMed Link] | [ Full text ]
  • Majima, H.J.;Oberley, T.D.;Furukawa, K.;Mattson, M.P.;Yen, H.C.;Szweda, L.I.;St Clair, D.K. "Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death." The Journal of biological chemistry 273, 14 (1998): 8217-24. [PubMed Link] | [ Full text ]
  • Keller, J.N.;Kindy, M.S.;Holtsberg, F.W.;St. Clair, D.K.;Yen, H.C.;Germeye, A.;Steiner, S.M.;Bruce-Heller, A.J.;Hutchins, J.B.;Mattson, M.P. "Mitochondrial MnSOD prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation and mitochondrial dysfunction" J. Neurosci. (1998):
  • Zhong, W.;Oberley, L.W.;Oberley, T.D.;St Clair, D.K. "Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase." Oncogene 14, 4 (1997): 481-90. [PubMed Link] | [ Full text ]
  • Kiningham, K.K.;St Clair, D.K. "Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells." Cancer research 57, 23 (1997): 5265-71. [PubMed Link] | [ Full text ]
  • Yen, H.C.;Oberley, T.D.;Vichitbandha, S.;Ho, Y.S.;St Clair, D.K. "The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice." The Journal of clinical investigation 98, 5 (1996): 1253-60. [PubMed Link] | [ Full text ]
  • Zhong, W.;Oberley, L.W.;Oberley, T.D.;Yan, T.;Domann, F.E.;St Clair, D.K. "Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells." Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 7, 9 (1996): 1175-86. [PubMed Link] | [ Full text ]
  • Yan, T.;Oberley, L.W.;Zhong, W.;St Clair, D.K. "Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts." Cancer research 56, 12 (1996): 2864-71. [PubMed Link] | [ Full text ]
  • Ragusa, R.J.;Chow, C.K.;St Clair, D.K.;Porter, J.D. "Extraocular, limb and diaphragm muscle group-specific antioxidant enzyme activity patterns in control and mdx mice." Journal of the neurological sciences 139, 2 (1996): 180-6. [PubMed Link] | [ Full text ]
  • Perera, C.S.;St Clair, D.K.;McClain, C.J. "Differential regulation of manganese superoxide dismutase activity by alcohol and TNF in human hepatoma cells." Archives of biochemistry and biophysics 323, 2 (1995): 471-6. [PubMed Link] | [ Full text ]
  • Li, J.J.;Oberley, L.W.;St Clair, D.K.;Ridnour, L.A.;Oberley, T.D. "Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase." Oncogene 10, 10 (1995): 1989-2000. [PubMed Link] |
  • Urano, M.;Kuroda, M.;Reynolds, R.;Oberley, T.D.;St Clair, D.K. "Expression of manganese superoxide dismutase reduces tumor control radiation dose: gene-radiotherapy." Cancer research 55, 12 (1995): 2490-3. [PubMed Link] | [ Full text ]
  • St Clair, D.K.;Jordan, J.A.;Wan, X.S.;Gairola, C.G. "Protective role of manganese superoxide dismutase against cigarette smoke-induced cytotoxicity." Journal of toxicology and environmental health 43, 2 (1994): 239-49. [PubMed Link] |
  • Wan, X.S.;Devalaraja, M.N.;St Clair, D.K. "Molecular structure and organization of the human manganese superoxide dismutase gene." DNA and cell biology 13, 11 (1994): 1127-36. [PubMed Link] | [ Full text ]
  • Carbone, G.M.;St Clair, D.K.;Xu, Y.A.;Rose, J.C. "Expression of manganese superoxide dismutase in ovine kidney cortex during development." Pediatric research 35, 1 (1994): 41-4. [PubMed Link] | [ Full text ]
  • St Clair, D.K.;Oberley, T.D.;Muse, K.E.;St Clair, W.H. "Expression of manganese superoxide dismutase promotes cellular differentiation." Free radical biology & medicine 16, 2 (1994): 275-82. [PubMed Link] |
  • Safford, S.E.;Oberley, T.D.;Urano, M.;St Clair, D.K. "Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase." Cancer research 54, 16 (1994): 4261-5. [PubMed Link] | [ Full text ]
  • Wan, X.S.;St Clair, D.K. "Thiol-modulating agents increase manganese superoxide dismutase activity in human lung fibroblasts." Archives of biochemistry and biophysics 304, 1 (1993): 89-93. [PubMed Link] | [ Full text ]
  • Wan, X.S.;St Clair, D.K. "Differential cytotoxicity of buthionine sulfoximine to "normal" and transformed human lung fibroblast cells." Cancer chemotherapy and pharmacology 33, 3 (1993): 210-4. [PubMed Link] |
  • St Clair, D.K.;Wan, X.S.;Oberley, T.D.;Muse, K.E.;St Clair, W.H. "Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase." Molecular carcinogenesis 6, 4 (1992): 238-42. [PubMed Link] | [ Full text ]
  • St Clair, W.H.;St Clair, D.K. "Effect of the Bowman-Birk protease inhibitor on the expression of oncogenes in the irradiated rat colon." Cancer research 51, 17 (1991): 4539-43. [PubMed Link] | [ Full text ]
  • Dwarakanath, B.S.;Wallen, C.A.;St Clair, D.K.;Wheeler, K.T. "Characterization of nuclear matrices prepared without salt extraction." Analytical biochemistry 198, 1 (1991): 68-74. [PubMed Link] | [ Full text ]
  • St Clair, D.K.;Oberley, T.D.;Ho, Y.S. "Overproduction of human Mn-superoxide dismutase modulates paraquat-mediated toxicity in mammalian cells." FEBS letters 293, 1-2 (1991): 199-203. [PubMed Link] | [ Full text ]
  • St Clair, D.K.;Holland, J.C. "Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells." Cancer research 51, 3 (1991): 939-43. [PubMed Link] | [ Full text ]
  • St Clair, D.K.;Oberley, L.W. "Manganese superoxide dismutase expression in human cancer cells: a possible role of mRNA processing." Free radical research communications 12-13 Pt 2, (1991): 771-8. [PubMed Link] |
  • Hendrie, H.C.;Clair, D.K.;Brittain, H.M.;Fadul, P.E. "A study of anxiety/depressive symptoms of medical students, house staff, and their spouses/partners." The Journal of nervous and mental disease 178, 3 (1990): 204-7. [PubMed Link] |
  • Rybak, S.M.;Auld, D.S.;St Clair, D.K.;Yao, Q.Z.;Fett, J.W. "C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin." Biochemical and biophysical research communications 162, 1 (1989): 535-43. [PubMed Link] |
  • St Clair, D.K.;Rybak, S.M.;Riordan, J.F.;Vallee, B.L. "Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of 40S ribosomes." Biochemistry 27, 19 (1988): 7263-8. [PubMed Link] |
  • St Clair, D.K.;Rybak, S.M.;Riordan, J.F.;Vallee, B.L. "Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of ribosomes." Proceedings of the National Academy of Sciences of the United States of America 84, 23 (1987): 8330-4. [PubMed Link] | [ Full text ]
  • Oberley, L.W.;St Clair, D.K.;Autor, A.P.;Oberley, T.D. "Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation." Archives of biochemistry and biophysics 254, 1 (1987): 69-80. [PubMed Link] |
  • Lobb, R.R.;Rybak, S.M.;St Clair, D.K.;Fett, J.W. "Lysates of two established human tumor lines contain heparin-binding growth factors related to bovine acidic brain fibroblast growth factor." Biochemical and biophysical research communications 139, 3 (1986): 861-7. [PubMed Link] | [ Full text ]
  • St Clair, D.K.;Presper, K.A.;Smith, P.L.;Stump, D.C.;Heath, E.C. "Bovine angiotensin-converting enzyme: amino-terminal sequence analysis and preliminary characterization of a hybridization-selected primary translation product." Biochemical and biophysical research communications 141, 3 (1986): 968-72. [PubMed Link] |