Changcheng Zhou, Ph.D.

Bio / Education: 

B.S., Molecular Biology, Jilin University
M.S., Biochemistry, Jilin University
Ph.D., Biological Sciences, University of California, Irvine
Senior Fellow, University of Washington
Postdoctoral Fellow, Rockefeller University

Research Description: 

Molecular Mechanisms of Atherosclerosis and Metabolic Disorders.

LAB NEWS:
2017
• Zhou lab research highlighted by UK press.
2016
• Dr. Zhou receives Barnstable Brown Diabetes and Obesity Center “Fred and Marcielle de Beer Award” for outstanding achievements in diabetes.
• Robert Helsley receives the American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology Travel Award for Young Investigators.
• Congratulations to Dr. Robert Helsley for successfully defending his dissertation! Robert Helsley also wins the Student of the Year 2016 award.
2015
• Robert Helsley Wins Best Poster Presentation Award (Category Student) at the 18th Annual Gill Heart Institute Cardiovascular Research Day.
• Yipeng Sui Wins Second Place Best Poster Presentation Award (Category Fellow) at the 2015 Annual Barnstable Brown Obesity & Diabetes Research Day.
• Robert Helsley Wins Best Poster Presentation Award (Category Student) at the 2015 Annual Barnstable Brown Obesity & Diabetes Research Day.
• Yipeng Sui Receives ATVB Travel Award.
2014
• Zhou Lab Reveals a Molecular Link Between Vascular Inflammation and Obesity.
• Robert Helsley Awarded PhRMA Foundation Predoctoral Fellowship.
• Yipeng Sui Receives Multiple Awards Including an American Heart Association Postdoctoral Fellowship in 2014.
• Yipeng Sui Receives AHA Travel Award.
• Zhou Lab Finds Bisphenol A Increases Athersclerosis in Mouse Model.
• Robert Helsley Named a Finalist in Graduate Student Poster Competition at the Second Annual SEC Symposium.
• Yipeng Sui Wins Best Poster Presentation Award (Category Fellow) at the 2014 Annual Barnstable Brown Obesity & Diabetes Research Day.
• Robert Helsley Wins Fourth Place Best Poster Presentation Award (Category Student) at the 2014 Annual Barnstable Brown Obesity & Diabetes Research Day.
• Robert Helsley Wins Second Place Best Poster Presentation Award at the Ohio Valley Affiliates for Life Sciences (OVALS) Conference.
• Yipeng Sui Wins Best Poster Presentation Award (Category Fellow) at the 2014 Aortic Symposium.
2013
• Robert Helsley Receives Graduate Student Travel Award to the 2013 Experimental Biology Annual Meeting. Robert Helsley also Wins Fourth Place in Graduate Student Best Abstract Competition.
2012
• Se-Hyung Park Wins Best Poster Presentation Award (Category Fellow) at the 2012 Annual Barnstable Brown Obesity & Diabetes Research Day.
2011
• Yipeng Sui Wins Second Place Best Poster Presentation Award (Category Fellow) at the Inaugural Barnstable Brown Obesity & Diabetes Research Day.

Selected Publications: 

Click links to access reprints in PDF format. These reprints are provided for scholarly or informational use exclusively. Other uses require permission of the copyright holders.

Helsley, R.N., Sui, Y., Park, S-H., Liu, Z., Lee, R.G., Zhu, B., Kern, P.A., and Zhou, C.
Targeting IκB kinase β in adipocyte lineage cells for treatment of obesity and metabolic dysfunctions.
Stem Cells 2016; 34(7):1883-1895.

Park, S-H., Liu, Z., Sui, Y., Helsley, R.N., Powell, D.K., Zhu, B., Kern, P.A., and Zhou, C.
IKKβ is essential for adipocyte survival and adaptive adipose remodeling in obesity.
Diabetes 2016; 65(6):1616-1629.

Zhou, C.
Novel functions of PXR in cardiometabolic disease.
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 2016; 1859(9):1112-1120.

Sui, Y.*, Helsley, R.N.*, Park, S-H., Song, X., Liu, Z., and Zhou, C.
Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.
Molecular Endocrinology 2015; 29(5):765-776.

Cui, W., Maimaitiyiming, M., Zhou, Q., Norman, H., Zhou, C., and Wang, S.
Interaction of thrombospondin1 and CD36 contributes to obesity-associated podocytopathy.
Biochimica et Biophysica Acta-Molecular Basis of Disease 2015; 1852(7):1323-1333.

Sui, Y., Park, S-H., Xu, J., Monette, S., Helsley, R.N., Han, S.S., and Zhou, C.
IKKβ links vascular inflammation to obesity and atherosclerosis.
Journal of Experimental Medicine 2014; 211 (5):869-886.

Sui, Y., Park, S-H., Helsley, R.N., Sunkara, M., Gonzalez, F.J., Morris, A.J., and Zhou, C.
Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice.
Journal of the American Heart Association 2014; 3:e000492.

Helsley, R.N.*, Sui, Y.*, Ai, N., Park, S-H., Welsh, W.J., and Zhou, C.
Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.
Molecular Pharmacology 2013; 83(6):1190-1199.

Park, S-H., Sui, Y., Gizard, F., Xu, J., Rios-Pilier, J., Helsley, R.N., Han, S.S., and Zhou, C.
Myeloid-specific IKKβ deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice
Arteriosclerosis, Thrombosis, and Vascular Biology 2012; 32(12):2869-2876.

Sui, Y., Ai, N., Park, S-Y., Rios-Pilier, J., Perkins, J.T., Welsh, W.J., and Zhou, C.
Bisphenol A and its analogs activate human pregnane X receptor
Environmental Health Perspectives 2012; 120(3):399-405.

Sui, Y., Xu, J., Rios-Pilier, J., and Zhou, C.
Deficiency of PXR decreases atherosclerosis in apoE-deficient mice.
Journal of Lipid Research 2011; 52 (9): 1652-1659.

Zhou, C., Pridgen, B., King, N., Xu, J., and Breslow, J.L.
Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis; a model of type 1 diabetic macrovascular disease.
Journal of Lipid Research 2011; 52 (8):1483-1493.

Zhou, C., King, N., Chen, K.Y., and Breslow, J.L.
Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice.
Journal of Lipid Research 2009; 50(10):2004-2013.

Zhou, C., Verma, S., and Blumberg, B.
The steroid and xenobiotic receptor, beyond xenobiotic metabolism.
Nuclear Receptor Signaling 2009; 7:e001.

Zhou, C., Poulton, E., Grun, F., Bammler, T.K., Blumberg, B., Thummel, K.E., and Eaton, D.L.
The dietary isothiocyanate, sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor (SXR).
Molecular Pharmacology 2007; 71(1):220-229.

Zhou, C., Tabb, M.M., Nelson E.L., Grun, F., Verma, S., Sadatrafiei, A., Lin, M., Mallick, S., Forman, B.M., Thummel, K.E., and Blumberg, B.
Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation.
Journal of Clinical Investigation 2006; 116(8): 2280–2289.

Zhou, C., Assem, M., Tay, J., Watkins, P.B., Blumberg, B., Schuetz, E.G., and Thummel, K.E.
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.
Journal of Clinical Investigation 2006; 116(6):1703-1712.

Xu, Y., Iwanaga, K., Zhou, C., Cheesman, M.J., Farin, F., and Thummel, K.E.
Selective induction of intestinal CYP3A23 by 1α,25-dihydorxyvitaminD3 in rats.
Biochemical Pharmacology 2006; 72(3): 385-392.

Tabb, M.M., Kholodovych, V., Grun, F., Zhou, C., Welsh, W.J., and Blumberg, B.
Polychlorinated biophenyls inhibit the human xenobiotic response mediated by the Steroid and Xenobiotic Receptor (SXR).
Environmental Health Perspectives 2004; 112(2):163-169.

Zhou, C., Tabb, M.M., Sadatrafiei, A., Grun, F., and Blumberg, B.
Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes.
Drug Metabolism and Disposition 2004; 32(10):1075-1082.

Zhou, C., Tabb, M.M., Sadatrafiei, A., Grun, F., Sun, A., and Blumberg, B.
Hyperforin, the active component of St. John’s wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-κB-independent pathway.
Journal of Clinical Immunology 2004; 24(6):623-636.

Zhou, C. and Blumberg, B.
Overlapping gene structure of human VLCAD and DLG4.
Gene 2003; 305(2):161-166.

Tabb, M. M., Sun, A., Zhou, C., Grun, F., Errandi, J., Romero, K., Pham, H., Inoue, S., Mallick, S., Lin, M., Forman, B.M., and Blumberg, B.
Vitamin K2 regulation of bone homeostasis is mediated by the orphan receptor, SXR.
Journal of Biological Chemistry 2003; 278(45):43919-43927.

Tabb, M.M., Zhou, C., and Blumberg, B.
SXR and the xenobiotic response.
Toxicogenomics, (Inoue, T., and Pennie, W. D., eds), 2002; pp. 115-125, Springer-Verlag, Tokyo.

Grun, F., Venkatesan, R.N., Tabb, M.M., Zhou, C., Cao, J., Hemmati, D., and Blumberg, B.
Benzoate X receptor alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors.
Journal of Biological Chemistry 2002; 27 (46): 43691-43697.

Ball, A.R. Jr., Schmiesing, J.A., Zhou, C., Gregson, H.C., Okada, Y., Doi, T., and Yokomori, K.
Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7.
Molecular and Cellular Biology 2002; 22(16): 5769-5781.

Yang, B.Z., Ding, J.H., Zhou, C., Dimachkie, M.M., Sweetman, L., Dasouki, M.J., Wilkinson, J., and Roe, C.R.
Identification of a novel mutation in patients with Medium-Chain Acyl-CoA Dehydrogenase deficiency.
Molecular Genetics and Metabolism 2000; 69(3): 259-262.

Qi, J., Zhou, C., Zhou, H., Li, W., Liu, B., Li, Y., and Fu., N.
Searching for the peptide ligands of interleukin-2 in phage-displayed peptide library.
Chinese Journal of Biochemistry and Molecular Biology 1999; 15(5): 752-755.

Liu, B., Li, Y., Wang, L., Yu, C., Yang, G., Fu, N., Zhou, C., Qi, J., Zhou, H., and Li, W.
Identification of IL-2Rα epitope sequences by phage peptide library.
Chinese Journal of Immunology 1998; 15(12): 534-536.

Zhou, C., Qi, J., Li, T., Zhou, H., and Li, W.
Searching for the peptide ligands of interleukin-2 receptor alpha chain in a phage-displayed peptide library.
Chemical Research in Chinese Universities 1998; 14(4): 430-432.

Li, T., Zhou, C., Fang, R., Qi, J., Zhou, H., and Li, W.
A simple method designed for the separation of biotinylated ligate from free biotin.
Chemical Research in Chinese Universities 1998; 14(4): 420-422.