Anika M. Hartz, Ph.D.

Bio / Education: 

2005 PhD Pharmaceutical Sciences - University of Heidelberg, Germany
2002 BS Pharmacy - University of Heidelberg, Germany

Research Description: 

Regulation of blood-brain barrier function in neurodegenerative diseases with a focus on Alzheimer’s disease, epilepsy and brain cancer.

Grants: 

1R01AG039621 Blood-Brain Barrier P-Glycoprotein: a new target for Alzheimer's disease (NIH/NIA)
1R01NS079507 Blood-Brain Barrier function in epilepsy: new targets for therapy (NIH/NINDS)

Selected Publications: 

1. Wolf A, Bauer B, Hartz AMS, ABC Transporters and the Alzheimer's Disease Enigma, Frontiers in Psychiatry 3:54, 2012 (Invited Review) [PubMed] [Full Text]

2. Hartz AMS, Bauer B, Soldner ELB, Wolf A, Boy S, Backhaus R, Mihaljevic I, Bogdahn U, Klünemann HH, Schuierer G, Schlachetzki F, Amyloid beta mediates loss of blood-brain barrier integrity in mice and humans with cerebral amyloid angiopathy, Stroke 43(2):514-23, 2012 [PubMed] [Full Text]

3. Hartz AMS, Mahringer A, Miller DS, Bauer B, 17β-estradiol: a powerful modulator of blood-brain barrier BCRP activity, Journal of Cerebral Blood Flow and Metabolism 30(10):1742-55, 2010 [PubMed] [Full Text]

4. Hartz AMS, Miller DS, Bauer B, Restoring blood-brain barrier P-glycoprotein reduces brain Aβ in a mouse model of Alzheimer’s disease, Molecular Pharmacology 77(5):715-23, 2010 [PubMed] [Full Text]

5. Hartz AMS, Bauer B, Block ML, Hong JS, Miller DS, Diesel exhaust particles induce oxidative stress, pro-inflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier, FASEB Journal 22:2723-2733, 2008 [PubMed] [Full Text]

[More publications on PubMed]