Analia Loria, Ph.D.

Research Interest

Background:
I am a highly trained cardiovascular scientist with a strong background in cardiovascular physiology, biochemistry and vascular biology of vasoactive peptides, with particular expertise in the effects of renin-angiotensin system (RAS) on the cardiovascular system. As a postdoctoral fellow at the Medical College of Georgia, I was trained in the study of RAS components signaling in rats exposed to maternal separation, a model that mimics the effects of early life stress (ELS) on the cardiovascular system. Our work revealed that maternal separation sensitizes the sympathetic nervous system (SNS) and the RAS-mediated responses in rats. My postdoctoral work was supported by an American Heart Association Fellowship early on. I was subsequently awarded a K99 from the National Heart Lung and Blood Institute focused on the influence of early life behavioral stress on renal function.
Current Research Interests:
Since joining the University of Kentucky as an Assistant Professor in September 2013, I have continued to use maternal separation superimposed with high fat diet (HFD) in rats and mice on the R00 phase from my K award. I established a laboratory highly focused on the study of the cardiovascular function, including the measurement of conscious blood pressure, assessment of acute experiments under anesthesia, assessment of the vascular responses in vivo and ex vivo, and access to the measurement of the renal nerve activity. We recently showed that attenuation of the stress response early in life abrogates the maternal separation-induced increase in adiposity and metabolic dysfunction in rats. We use a novel mouse model of neglect, a form of ELS that combines maternal separation and early weaning (MSEW). This work laid the foundation for our studies to identify potentially novel mechanisms by which MSEW stimulates the development of hypertension via adipose tissue-derived factors that impact the blood pressure control.

https://med.uky.edu/sites/default/files/Slide1.jpg

Also, see Animal models of Early life stress on the right.....

Watch a Lab Video

Dr. Loria to Present Gender-Based Cardiovascular and Metabolic Research at 2015 APS Conference

http://uknow.uky.edu/content/loria-present-gender-based-cardiovascular-a...

PubMed Publications: 

  • Murphy, M.O.;Cohn, D.M.;Loria, A.S. "Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents." Neuroscience and biobehavioral reviews 74, Pt B (2017): 453-465. [PubMed Link] | [ Full text ]
  • Murphy, M.O.;Herald, J.B.;Wills, C.T.;Unfried, S.G.;Cohn, D.M.;Loria, A.S. "Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress." American journal of physiology. Endocrinology and metabolism 312, 2 (2017): E98-E108. [PubMed Link] | [ Full text ]
  • Loria, A.S. "Can we fight chronic kidney disease by targeting endothelial HB-EGF?" American journal of physiology. Renal physiology 311, 2 (2016): F406-8. [PubMed Link] | [ Full text ]
  • Loria, A.S.;Pollock, D.M.;Pollock, J.S. "Angiotensin II is required to induce exaggerated salt sensitivity in Dahl rats exposed to maternal separation." Physiological reports 3, 5 (2015): [PubMed Link] | [ Full text ]
  • Reverte, V.;Tapia, A.;Loria, A.;Salazar, F.;Llinas, M.T.;Salazar, F.J. "COX2 inhibition during nephrogenic period induces ANG II hypertension and sex-dependent changes in renal function during aging." American journal of physiology. Renal physiology 306, 5 (2014): F534-41. [PubMed Link] | [ Full text ]
  • Loria, A.S.;Ho, D.H.;Pollock, J.S. "A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood." Acta physiologica (Oxford, England) 210, 2 (2014): 277-87. [PubMed Link] | [ Full text ]
  • Loria, A.S.;Brinson, K.N.;Fox, B.M.;Sullivan, J.C. "Sex-specific alterations in NOS regulation of vascular function in aorta and mesenteric arteries from spontaneously hypertensive rats compared to Wistar Kyoto rats." Physiological reports 2, 8 (2014): [PubMed Link] | [ Full text ]
  • Loria, A.S.;Yamamoto, T.;Pollock, D.M.;Pollock, J.S. "Early life stress induces renal dysfunction in adult male rats but not female rats." American journal of physiology. Regulatory, integrative and comparative physiology 304, 2 (2013): R121-9. [PubMed Link] | [ Full text ]
  • Loria, A.S.;Kang, K.T.;Pollock, D.M.;Pollock, J.S. "Early life stress enhances angiotensin II-mediated vasoconstriction by reduced endothelial nitric oxide buffering capacity." Hypertension (Dallas, Tex. : 1979) 58, 4 (2011): 619-26. [PubMed Link] | [ Full text ]
  • Reverte, V.;Tapia, A.;Moreno, J.M.;Rodríguez, L.;Salazar, F.;Llinás, M.T.;Salazar, F.J. "Renal effects of prolonged high protein intake and COX2 inhibition on hypertensive rats with altered renal development." American journal of physiology. Renal physiology 301, 2 (2011): F327-33. [PubMed Link] | [ Full text ]
  • Loria, A.S.;D'Angelo, G.;Pollock, D.M.;Pollock, J.S. "Early life stress downregulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats." American journal of physiology. Regulatory, integrative and comparative physiology 299, 1 (2010): R185-91. [PubMed Link] | [ Full text ]
  • Loria, A.S.;Pollock, D.M.;Pollock, J.S. "Early life stress sensitizes rats to angiotensin II-induced hypertension and vascular inflammation in adult life." Hypertension (Dallas, Tex. : 1979) 55, 2 (2010): 494-9. [PubMed Link] | [ Full text ]
  • Salazar, F.;Reverte, V.;Saez, F.;Loria, A.;Llinas, M.T.;Salazar, F.J. "Age- and sodium-sensitive hypertension and sex-dependent renal changes in rats with a reduced nephron number." Hypertension 51, 4 (2008): 1184-9. [PubMed Link] | [ Full text ]
  • Saez, F.;Castells, M.T.;Zuasti, A.;Salazar, F.;Reverte, V.;Loria, A.;Salazar, F.J. "Sex differences in the renal changes elicited by angiotensin II blockade during the nephrogenic period." Hypertension 49, 6 (2007): 1429-35. [PubMed Link] | [ Full text ]
  • Loria, A.;Reverte, V.;Salazar, F.;Saez, F.;Llinas, M.T.;Salazar, F.J. "Changes in renal hemodynamics and excretory function induced by a reduction of ANG II effects during renal development." American journal of physiology. Regulatory, integrative and comparative physiology 293, 2 (2007): R695-700. [PubMed Link] | [ Full text ]
  • Loria, A.;Reverte, V.;Salazar, F.;Saez, F.;Llinas, M.T.;Salazar, F.J. "Sex and age differences of renal function in rats with reduced ANG II activity during the nephrogenic period." American journal of physiology. Renal physiology 293, 2 (2007): F506-10. [PubMed Link] | [ Full text ]
  • Costa, M.A.;Elesgaray, R.;Loria, A.;Balaszczuk, A.M.;Arranz, C. "Vascular and renal effects of dopamine during extracellular volume expansion: Role of nitric oxide pathway." Life sciences 78, 14 (2006): 1543-9. [PubMed Link] | [ Full text ]
  • Salazar, F.J.;Chadwick, D.;Pain, B.F.;Hatch, D.;Owen, E. "Nitrogen budgets for three cropping systems fertilised with cattle manure." Bioresource technology 96, 2 (2005): 235-45. [PubMed Link] | [ Full text ]
  • Costa, M.A.;Loria, A.;Elesgaray, R.;Balaszczuk, A.M.;Arranz, C. "Role of nitric oxide pathway in hypotensive and renal effects of furosemide during extracellular volume expansion." Journal of hypertension 22, 8 (2004): 1561-9. [PubMed Link] | [ Full text ]
  • Costa Mde, L.;Loria, A.;Marchetti, M.;Balaszczuk, A.M.;Arranz, C.T. "Effects of dopamine and nitric oxide on arterial pressure and renal function in volume expansion." Clinical and experimental pharmacology & physiology 29, 9 (2002): 772-6. [PubMed Link] | [ Full text ]