B.S. Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan
Ph.D. Radiological Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Dr Lin's training experiences were in medical physics, with an emphasis on imaging-based assessments of vascular and metabolic physiology. She has been developing and using MRI and PET imaging to quantify cerebral blood flow, cerebral blood volume, and cerebral metabolic rates of glucose and oxygen both in humans and animals. Her long-term goal for developing such methods is to apply them in aging and age-related neurodegenerative disorders, using them both to investigate pathophysiology and as biomarkers for disease progression and treatment efficacy. Her research also focuses on developing dietary and pharmacological interventions that can slow down brain aging and the progression of Alzheimer’s disease.
Lin AL, Gao JH and Fox PT (2012). Neurovascular and Neurometabolic Uncoupling in the Visual Cortex, Visual Cortex - Current Status and Perspectives, Stephane Molotchnikoff and Jean Rouat (Ed.), ISBN: 978-953-51-0760-6, InTech, Available from: http://www.intechopen.com/books/visual-cortex-current-status-and-perspec...
Selected peer-review publications:
1. Lin, A.L.;Fox, P.T.;Yang, Y.;Lu, H.;Tan, L.H.;Gao, J.H. "Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI." NeuroImage 44, 1 (2009): 16-22.
2. Lin, A.L.;Fox, P.T.;Yang, Y.;Lu, H.;Tan, L.H.;Gao, J.H. "Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF." Magnetic Resonance in Medicine 60, 2 (2008): 380-9.
3. Lin, A.L.;Fox, P.T.;Hardies, J.;Duong, T.Q.;Gao, J.H. "Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex." Proceedings of the National Academy of Sciences of the United States of America 107, 18 (2010): 8446-51.
4. Lin, A.L.;Zheng, W.;Halloran, J.J.;Burbank, R.R.;Hussong, S.A.;Hart, M.J.;Javors, M.;Shih, Y.Y.;Muir, E.;Solano Fonseca, R.;Strong, R.;Richardson, A.G.;Lechleiter, J.D.;Fox, P.T.;Galvan, V. "Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease." Journal of Cerebral Blood Flow and Metabolism 33, 9 (2013): 1412-21.
5. Lin, A.L.;Coman, D.;Jiang, L.;Rothman, D.L.;Hyder, F. "Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity." Journal of Cerebral Blood Flow and Metabolism 34, 9 (2014): 1440-3.