Ai-Ling Lin, Ph.D.

Bio / Education: 

B.S. Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

Ph.D. Radiological Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

Research Description: 

Dr Lin's training experiences were in medical physics, with an emphasis on imaging-based assessments of vascular and metabolic physiology. She has been developing and using MRI and PET imaging to quantify cerebral blood flow, cerebral blood volume, and cerebral metabolic rates of glucose and oxygen both in humans and animals. Her long-term goal for developing such methods is to apply them in aging and age-related neurodegenerative disorders, using them both to investigate pathophysiology and as biomarkers for disease progression and treatment efficacy. Her research also focuses on developing dietary and pharmacological interventions that can slow down brain aging and the progression of Alzheimer’s disease.

Grants: 
Selected Publications: 

Book Chapters
Lin AL, Gao JH and Fox PT (2012). Neurovascular and Neurometabolic Uncoupling in the Visual Cortex, Visual Cortex - Current Status and Perspectives, Stephane Molotchnikoff and Jean Rouat (Ed.), ISBN: 978-953-51-0760-6, InTech, Available from: http://www.intechopen.com/books/visual-cortex-current-status-and-perspec...

Selected peer-review publications:
1. Lin, A.L.;Fox, P.T.;Yang, Y.;Lu, H.;Tan, L.H.;Gao, J.H. "Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI." NeuroImage 44, 1 (2009): 16-22.

2. Lin, A.L.;Fox, P.T.;Yang, Y.;Lu, H.;Tan, L.H.;Gao, J.H. "Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF." Magnetic Resonance in Medicine 60, 2 (2008): 380-9.

3. Lin, A.L.;Fox, P.T.;Hardies, J.;Duong, T.Q.;Gao, J.H. "Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex." Proceedings of the National Academy of Sciences of the United States of America 107, 18 (2010): 8446-51.

4. Lin, A.L.;Zheng, W.;Halloran, J.J.;Burbank, R.R.;Hussong, S.A.;Hart, M.J.;Javors, M.;Shih, Y.Y.;Muir, E.;Solano Fonseca, R.;Strong, R.;Richardson, A.G.;Lechleiter, J.D.;Fox, P.T.;Galvan, V. "Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease." Journal of Cerebral Blood Flow and Metabolism 33, 9 (2013): 1412-21.

5. Lin, A.L.;Coman, D.;Jiang, L.;Rothman, D.L.;Hyder, F. "Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity." Journal of Cerebral Blood Flow and Metabolism 34, 9 (2014): 1440-3.

PubMed Publications: 

  • Lin, A.L.;Jahrling, J.B.;Zhang, W.;DeRosa, N.;Bakshi, V.;Romero, P.;Galvan, V.;Richardson, A. "Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37, 1 (2017): 217-226. [PubMed Link] | [ Full text ]
  • Ighodaro, E.T.;Abner, E.L.;Fardo, D.W.;Lin, A.L.;Katsumata, Y.;Schmitt, F.A.;Kryscio, R.J.;Jicha, G.A.;Neltner, J.H.;Monsell, S.E.;Kukull, W.A.;Moser, D.K.;Appiah, F.;Bachstetter, A.D.;Van Eldik, L.J.;Alzheimer's Disease Neuroimaging Initiative, (A.D.N.I.).;Nelson, P.T. "Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37, 1 (2017): 201-216. [PubMed Link] | [ Full text ]
  • Kochunov, P.;Wey, H.Y.;Fox, P.T.;Lancaster, J.L.;Davis, M.D.;Wang, D.J.;Lin, A.L.;Bastarrachea, R.A.;Andrade, M.C.;Mattern, V.;Frost, P.;Higgins, P.B.;Comuzzie, A.G.;Voruganti, V.S. "Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (<i>Papio hamadryas</i> sp.)." Frontiers in neuroscience 11, (2017): 49. [PubMed Link] | [ Full text ]
  • Anderson, K.L.;Frazier, H.N.;Maimaiti, S.;Bakshi, V.V.;Majeed, Z.R.;Brewer, L.D.;Porter, N.M.;Lin, A.L.;Thibault, O. "Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism." The journals of gerontology. Series A, Biological sciences and medical sciences 72, 2 (2017): 189-197. [PubMed Link] | [ Full text ]
  • Parikh, I.;Guo, J.;Chuang, K.H.;Zhong, Y.;Rempe, R.G.;Hoffman, J.D.;Armstrong, R.;Bauer, B.;Hartz, A.M.;Lin, A.L. "Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions." Aging 8, 11 (2016): 2814-2826. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Butterfield, D.A.;Richardson, A. "mTOR: Alzheimer's disease prevention for APOE4 carriers." Oncotarget 7, 29 (2016): 44873-44874. [PubMed Link] | [ Full text ]
  • Guo, J.;Bakshi, V.;Lin, A.L. "Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice." Frontiers in aging neuroscience 7, (2015): 213. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Zhang, W.;Gao, X.;Watts, L. "Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain." Neurobiology of aging 36, 7 (2015): 2296-303. [PubMed Link] | [ Full text ]
  • Richardson, A.;Galvan, V.;Lin, A.L.;Oddo, S. "How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story." Experimental gerontology 68, (2015): 51-8. [PubMed Link] | [ Full text ]
  • Ramage, A.E.;Lin, A.L.;Olvera, R.L.;Fox, P.T.;Williamson, D.E. "Resting-state regional cerebral blood flow during adolescence: associations with initiation of substance use and prediction of future use disorders." Drug and alcohol dependence 149, (2015): 40-8. [PubMed Link] | [ Full text ]
  • Pulliam, D.A.;Deepa, S.S.;Liu, Y.;Hill, S.;Lin, A.L.;Bhattacharya, A.;Shi, Y.;Sloane, L.;Viscomi, C.;Zeviani, M.;Van Remmen, H. "Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses." The Biochemical journal 462, 2 (2014): 359-71. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Coman, D.;Jiang, L.;Rothman, D.L.;Hyder, F. "Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 34, 9 (2014): 1440-3. [PubMed Link] | [ Full text ]
  • Sancheti, H.;Patil, I.;Kanamori, K.;Díaz Brinton, R.;Zhang, W.;Lin, A.L.;Cadenas, E. "Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 34, 11 (2014): 1749-60. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Rothman, D.L. "What have novel imaging techniques revealed about metabolism in the aging brain?" Future neurology 9, 3 (2014): 341-354. [PubMed Link] |
  • Evans, T.M.;Van Remmen, H.;Purkar, A.;Mahesula, S.;Gelfond, J.A.;Sabia, M.;Qi, W.;Lin, A.L.;Jaramillo, C.A.;Haskins, W.E. "Microwave &amp; Magnetic (M<sup>2</sup>) Proteomics of a Mouse Model of Mild Traumatic Brain Injury." Translational proteomics 3, (2014): 10-21. [PubMed Link] |
  • Lin, A.L.;Zheng, W.;Halloran, J.J.;Burbank, R.R.;Hussong, S.A.;Hart, M.J.;Javors, M.;Shih, Y.Y.;Muir, E.;Solano Fonseca, R.;Strong, R.;Richardson, A.G.;Lechleiter, J.D.;Fox, P.T.;Galvan, V. "Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 33, 9 (2013): 1412-21. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Pulliam, D.A.;Deepa, S.S.;Halloran, J.J.;Hussong, S.A.;Burbank, R.R.;Bresnen, A.;Liu, Y.;Podlutskaya, N.;Soundararajan, A.;Muir, E.;Duong, T.Q.;Bokov, A.F.;Viscomi, C.;Zeviani, M.;Richardson, A.G.;Van Remmen, H.;Fox, P.T.;Galvan, V. "Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 33, 10 (2013): 1605-11. [PubMed Link] | [ Full text ]
  • Mimun, L.C.;Ajithkumar, G.;Pokhrel, M.;Yust, B.G.;Elliott, Z.G.;Pedraza, F.;Dhanale, A.;Tang, L.;Lin, A.L.;Dravid, V.P.;Sardar, D.K. "Bimodal Imaging Using Neodymium Doped Gadolinium Fluoride Nanocrystals with Near-Infrared to Near-Infrared Downconversion Luminescence and Magnetic Resonance Properties." Journal of materials chemistry. B, Materials for biology and medicine 1, 41 (2013): 5702-5710. [PubMed Link] |
  • Ajithkumar, G.;Yoo, B.;Goral, D.E.;Hornsby, P.J.;Lin, A.L.;Ladiwala, U.;Dravid, V.P.;Sardar, D.K. "Multimodal bioimaging using rare earth doped Gd<sub>2</sub>O<sub>2</sub>S: Yb/Er phosphor with upconversion luminescence and magnetic resonance properties." Journal of materials chemistry. A, Materials for energy and sustainability 1, 11 (2013): 1561-1572. [PubMed Link] |
  • Lin, A.L.;Qin, Q.;Zhao, X.;Duong, T.Q. "Blood longitudinal (T1) and transverse (T2) relaxation time constants at 11.7 Tesla." Magma (New York, N.Y.) 25, 3 (2012): 245-9. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Poteet, E.;Du, F.;Gourav, R.C.;Liu, R.;Wen, Y.;Bresnen, A.;Huang, S.;Fox, P.T.;Yang, S.H.;Duong, T.Q. "Methylene blue as a cerebral metabolic and hemodynamic enhancer." PloS one 7, 10 (2012): e46585. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Laird, A.R.;Fox, P.T.;Gao, J.H. "Multimodal MRI neuroimaging biomarkers for cognitive normal adults, amnestic mild cognitive impairment, and Alzheimer's disease." Neurology research international 2012, (2012): 907409. [PubMed Link] | [ Full text ]
  • Uh, J.;Lin, A.L.;Lee, K.;Liu, P.;Fox, P.;Lu, H. "Validation of VASO cerebral blood volume measurement with positron emission tomography." Magnetic resonance in medicine 65, 3 (2011): 744-9. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Lu, H.;Fox, P.T.;Duong, T.Q. "Cerebral Blood Volume Measurements - Gd_DTPA vs. VASO - and Their Relationship with Cerebral Blood Flow in Activated Human Visual Cortex." The open neuroimaging journal 5, (2011): 90-5. [PubMed Link] |
  • Samano, A.K.;Ohshima-Hosoyama, S.;Whitney, T.G.;Prajapati, S.I.;Kilcoyne, A.;Taniguchi, E.;Morgan, W.W.;Nelon, L.D.;Lin, A.L.;Togao, O.;Jung, I.;Rubin, B.P.;Nowak, B.M.;Duong, T.Q.;Keller, C. "Functional evaluation of therapeutic response for a mouse model of medulloblastoma." Transgenic research 19, 5 (2010): 829-40. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Fox, P.T.;Hardies, J.;Duong, T.Q.;Gao, J.H. "Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex." Proceedings of the National Academy of Sciences of the United States of America 107, 18 (2010): 8446-51. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Gao, J.H.;Duong, T.Q.;Fox, P.T. "Functional neuroimaging: a physiological perspective." Frontiers in neuroenergetics 2, (2010): [PubMed Link] | [ Full text ]
  • Lin, A.L.;Fox, P.T.;Yang, Y.;Lu, H.;Tan, L.H.;Gao, J.H. "Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI." NeuroImage 44, 1 (2009): 16-22. [PubMed Link] | [ Full text ]
  • Lin, A.L.;Fox, P.T.;Yang, Y.;Lu, H.;Tan, L.H.;Gao, J.H. "Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF." Magnetic resonance in medicine 60, 2 (2008): 380-9. [PubMed Link] | [ Full text ]
  • Lan, G.M.;Fu, Q.H.;Lin, A.L. " Effect of continuous renal replacement treatment on stress reaction in patients with severe trauma ." Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 16, 2 (2004): 106-8. [PubMed Link] |