Emeritus Professors


The Unified Theory of PAH Carcinogenicity accommodates the activities of methylated and
non-methylated polycyclic aromatic hydrocarbons (PAHs) and states that substitution of methyl
groups on meso-methyl substituted PAHs with hydroxy, acetoxy, chloride, bromide or sulfuric
acid ester groups imparts potent cancer producing properties.

Dr. James W.  Flesher and Dr Andreas F. Lehner (Michigan State University)   submitted an abstract which ended with "If every scientist working in the field of Structure-Carcinogenic Activity Relationships of Polycyclic Aromatic Compounds agreed with us, they would all be right"
The title:  The Carcinogenic Activities of Polycyclic Aromatic Compounds with Structure Type ArCH2X or ArX: A Paradigm Shift.

Dr. Flesher's latest publications:

"One electron oxidation of 3-methylcholanthrene: A chemical model for its mechanism of carcinogenesis " will be published in the Journal of Molecular Structure Volume 1137, in the 5 June 2017 issue, Pages 67–83

"Structure, function and carcinogenicity of metabolites of methylated and non-methylated polycyclic aromatic hydrocarbons: a comprehensive review" was published February 24th 2016 in the journal Toxicology Mechanisms and Methods.


Dr. Iwamoto's  past research investigated the central mechanisms of opioid and nicotine-induced pain relief. Dr. Iwamoto is enjoying his retirement by traveling the world with his wife Mary and playing duplicate bridge.


Past Research: Derivatives of phlorizin, the competitive inhibitor of glucose transport across the brush border of intestine and kidney, have been synthesized leading to the construction of 1) a photo-affinity labeling agent to identify the components of the membrane transporter; 2) an agent with the unexpected ability to reverse the malformation of the sickled red blood cell to its normal biconcave flexible bi-concave disk form. The agent was projected as a useful agent to reverse the acute onset sickling crisis in Sickle Cell Anemia patients;  3) the preparation of a matrix possessing multiple, effectively spaced inhibitor moieties. This complex was capable of reducing the post-prandial duodenal absorption of glucose and insulin release without causing malabsorption in animal tests and was viewed as a possible remedy  in managing the obese diabetic patient. We obtained U.S. Patents for these agents.

Current activities: Camping with motorhome, tent and canoe in Canada and 49 US states; world wide travel adventures; stained glass hobby.