DR. DONALD DIEDRICH
Past Research: Derivatives of phlorizin, the competitive inhibitor of glucose transport across the brush border of intestine and kidney, have been synthesized leading to the construction of 1) a photo-affinity labeling agent to identify the components of the membrane transporter; 2) an agent with the unexpected ability to reverse the malformation of the sickled red blood cell to its normal biconcave flexible bi-concave disk form. The agent was projected as a useful agent to reverse the acute onset sickling crisis in Sickle Cell Anemia patients; 3) the preparation of a matrix possessing multiple, effectively spaced inhibitor moieties. This complex was capable of reducing the post-prandial duodenal absorption of glucose and insulin release without causing malabsorption in animal tests and was viewed as a possible remedy in managing the obese diabetic patient. We obtained U.S. Patents for these agents.
Current activities: Camping with motorhome, tent and canoe in Canada and 49 US states; world wide travel adventures; stained glass hobby.